Assoc. ProfessorMoeava Tehei
- +61 2 4221 4730 Ext.4730 (Work)
- University of Wollongong, School of Physics, Faculty of Engineering and Information Sciences, Wollongong, NSW, 2522, Australia
RESEARCH INTERESTS
From Neutron Scattering and Instrumentation through Physical Chemistry to Human Health Applications
Tehei is a recognized expert in the use of radiation (neutrons, X-rays and Synchrotron) to study biological systems. During his Ph.D. in Physics, Assoc. Prof. Tehei initiated neutron scattering experiments on complex biological samples (ribosomes, proteins, entire cells). He was financed by a competitive studentship from the Region Rhone-Alpes (France), and worked on the development of neutron scattering methods, coupled with protein purification and biochemical sample characterization. The studies were highly successful, yielding publications in high impact journals and the Thesis Prize from the French Neutron Society. His postdoctoral period in New Zealand fostered Tehei's capacity for high quality research in different biomedical/biotechnology fields. For his Ph.D. and postdoctoral works, he was awarded the Young Researcher Prize from the French Society of Biophysics. In 2004, he was physicist and co-manager of the backscattering instrument IN13 at the world leader neutron centre Institut Laue Langevin in Grenoble. In parallel with his neutron work on protein dynamics, he has used SANS and synchrotron radiation to characterize the structures of the systems studied.
Assoc. Prof. Tehei's neutron studies of molecular dynamics in whole cells and in DHFR combined with his work on the medical beam line at the European Synchrotron Radiation Facility (ESRF-Grenoble-France), led to his interest in human health applications of his work and inspired him to develop an independent research program on the effects of radiation and drugs on various cell types in a cancer context.
At the University of Wollongong from 2008, he initiated a collaborative interaction with Prof. Nick Dixon. Prof. Dixon strives for a better understanding of the relations between dynamics, structures and function of proteins in the multiprotein molecular machine that synthesizes and repairs DNA. The study of DNA replication and reparation not only reveal the elegance of the cellular world, but also has potential to guide the rational design of new therapeutics and to optimize our cancer treatment approach. Since January 2010, Tehei started to collaborate with all the investigators from the CMRP at the UOW and founded the team Targeted Nano Therapies at the Illawarra Health and Medical Research Institute.
In 2014, Tehei moved in physics, and developed and became the academic program director of the new major Biomolecular physics. He was then appointed theme leader at the Centre for Medical Radiation Physics (CMRP), leading the new advances in nanoparticle dose enhanced image guided research topic with a goal to ultimately translate this research to clinical practice.
Media
Innovative new treatment more deadly on cancer (Nov 2014)
New brain cancer treatment twice as effective (Nov 2015)
DR MOEAVA TEHEI JOINS AS AN EDITORIAL BOARD MEMBER FOR SCIENTIFIC REPORTS (June 2016)
INNOVATION IN RADIATION APPLICATIONS HOSTED AT UOW (May 2017)
RESULTS FROM RECENT THREE MINUTE THESIS (3MT) COMPETITION (June 2017)
PHD STUDENT, ELETTE ENGELS TAKES THE AIP POSTGRADUATE EXCELLENCE MEDAL (Nov 2017)
CMRP HONOURED AT MEDPHYS 2017 (Dec 2017)
PHYSICS PHD STUDENT GIVING NEW HOPE TO BRAIN CANCER SUFFERERS (March 2018)
UOW RESEARCH HELPS SHED LIGHT ON AGGRESSIVE BRAIN CANCER (June 2018)
NEW MULTIMODAL APPROACH TO TREAT BRAIN TUMORS (Nov 2018)
Meet Wollongong's International Women's Day scholarship winners (March 2019)
Brain cancer researcher receives Dr Margaret Gardiner Scholarship
EIS students awarded PhD travel scholarship
Improving our treatment of brain cancer
Ultra-fine X-rays target brain cancer cells with precision
CMRP continues impressive success rate with AINSE scholarships applications
Research finds a potential new "silver bullet" nanoparticle to treat brain cancer
Promising new therapy for inoperable brain cancers
Sydney scientists have come up with a novel way to fight brain cancer
Australian scientists trial world-first 'silver' brain cancer therapy | 7NEWS
UOW brain cancer team boosted by anonymous $100k donation
UOW receives $100,000 donation to support brain cancer research
CMRP researchers meet with Minister of Health for French Polynesia
Congratulations to our Three Minute Thesis (3MT) Winners
UOW PhD candidate Sarah Vogel to compete in Asia Pacific finals of Three Minute Thesis Competition
Bigger is not always better in brain tumour treatment
Top students shine bright in graduation spotlight
Cancer diagnosis inspires University Medalist to pursue science
PhD candidate ‘cooking’ brain cancer with magnets
Legolas The Fisher Rat: A Hero in Glioblastoma Research
Why Relay for Life means the world to Corrimal cancer research Kiarn
Researchers awarded more than $2 million to improve cancer treatment outcomes
Microbeam plus radiosensitizers could optimize brain cancer treatment – physicsworld
FUNDING
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- PROJECT GRANTBoosting conventional radiotherapy with microbeams to advance cancer treatment outcomesNational Health and Medical Research Council1 Jan 2025 - 31 Dec 2028People funded by this grant:
- Martin O,
- Rozenfeld A,
- Lerch M,
- Tehei M,
- Corde S
- OTHER GRANTA pilot study on Microbeam Radiotherapy (MRT)-facilitated drug delivery in canine cancer patientsAustralian Nuclear Science and Technology Organisation1 Jan 2024 - 31 Dec 2024People funded by this grant:
- Tehei M,
- Lerch M
- OTHER GRANTA pilot study on Microbeam Radiotherapy (MRT)-facilitated drug delivery in canine cancer patients - Round 2Australian Nuclear Science and Technology Organisation1 Jan 2024 - 31 Dec 2024People funded by this grant:
- Tehei M
- OTHER GRANTENHANCING THE TREATMENT EFFICACY OF MICROBEAM RADIOTHERAPY BY ADJUVANT SYSTEMIC THERAPY (PART 1)Australian Nuclear Science and Technology Organisation1 Jan 2024 - 31 Dec 2024People funded by this grant:
- Tehei M,
- Bustillo JP
- OTHER GRANTUsing 3D in vitro tumour models to assess the efficacy of radiosensitiser for the enhancement of multiport synchrotron MRT for pre-clinical rat studyAustralian Nuclear Science and Technology Organisation1 Jan 2024 - 31 Dec 2024People funded by this grant:
- Tehei M
- INFRASTRUCTUREAdvancing High-Throughput Live Cell Imaging Capabilities with a Sartorius IncuCyte SX5University of Wollongong1 Jan 2023 - 31 Dec 2023People funded by this grant:
- SEED FUNDINGEnhancing the abscopal effects of Microbeam Radiotherapy to treat breast cancer metastasisUniversity of Wollongong1 Jan 2023 - 31 Dec 2023People funded by this grant:
- Martin O,
- Tehei M
- OTHER GRANTSelectively targeting 9L gliosarcoma in the brain of a Fischer 344 rat using ground-breaking new lanthanum manganite nanoparticlesAustralian Nuclear Science and Technology Organisation1 Jan 2023 - 31 Dec 2023People funded by this grant:
- Tehei M,
- Lerch M
- SEED FUNDINGThe SMART FLASH for cancer radiosurgery: Synchrotron Modulated Activation Radiation TherapyUniversity of Wollongong1 Jan 2023 - 31 Dec 2023People funded by this grant:
- Tehei M,
- Rozenfeld A,
- Jackson M,
- Engels E
- OTHER GRANTEnhancing synchrotron microbeam radiation therapy in vivo with high-Z nanoparticlesAustralian Synchrotron1 Jan 2022 - 31 Dec 2022People funded by this grant:
- Tehei M,
- Lerch M
- OTHER GRANTEnhancing synchrotron microbeam radiation therapy in vivo with high-Z nanoparticlesAustralian Nuclear Science and Technology Organisation1 Jan 2021 - 31 Dec 2021People funded by this grant:
- Tehei M
- OTHER GRANTInvestigation in vitro into the efficacy of radiosensitiser combinations in enhancing synchrotron radiation for pre-clinical rat studiesAustralian Nuclear Science and Technology Organisation1 Jan 2021 - 31 Dec 2021People funded by this grant:
- Tehei M
- OTHER GRANTRefining synchrotron microbeam radiation therapy techniques and Pre-emptive management protocol in vivoAustralian Nuclear Science and Technology Organisation1 Jan 2019 - 31 Dec 2019People funded by this grant:
- Tehei M,
- Corde S
- INFRASTRUCTUREThe IVIS SpectrumCT preclinical in vivo imaging systemUniversity of Wollongong1 Jan 2018 - 31 Dec 2018People funded by this grant:
- TRAVEL GRANTInvestigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the X-tream dosimetry systemAustralian Synchrotron1 Jan 2017 - 31 Dec 2017People funded by this grant:
- Tehei M,
- Lerch M,
- Li N
- OTHER GRANTInvestigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the x-tream dosimetry system and characterisation of DNA damage-repair with yH2AXAustralian Synchrotron1 Jan 2017 - 31 Dec 2017
- OTHER GRANTBD high throughput sampler (HTS microplate loader) for Fortessa flow cytometer etcUniversity of Wollongong1 Jan 2016 - 31 Dec 2016People funded by this grant:
- EXTERNAL GRANTNational Health and Medical Research Council1 Jan 2015 - 31 Dec 2015People funded by this grant:
- Delfgou S
- INFRASTRUCTUREContributions to Leica Dmi8 microscopeNational Health and Medical Research Council1 Jan 2015 - 31 Dec 2015People funded by this grant:
- PROJECT GRANTDesign and application of new nanomaterials theranostic platforms for targeted treatment of cancerNational Health and Medical Research Council1 Jan 2015 - 31 Dec 2017People funded by this grant:
- Tehei M,
- Rozenfeld A,
- Lerch M,
- Konstantinov K,
- Guatelli S
- TRAVEL GRANTInvestigation of the effects of tantalum pentoxide and bismuth oxide nano particles on 9L gliosarcoma and MDCK non cancerour cells using both synchrotron generated broad and micro-beams monitored by the X-tream dosimetry system.Australian Synchrotron1 Jan 2015 - 31 Dec 2015People funded by this grant:
- Lerch M,
- Petasecca M,
- Tehei M,
- Corde S
