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Huang, Xu-Feng Prof

Distinguished Professor

  • Illawarra Health and Medical Research Institute
  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Medicine
  • Professor - University of Wollongong 2004 -
  • Director - Centre for Translational Neuroscience 1999 - 2017

Overview


Distinguished Professor Xu-Feng Huang’s (MBBS, PhD, DSc) extensive research track record in neuropharmacology, metabolism, and molecular nutrition has led to significant impacts in combatting obesity induced by diet and antipsychotic drugs.  His contributions, supported by major Australian competitive funding, include identifying: (a) central leptin resistance in the late stages of obesity resulting in a  different treatment strategy, (b) the satiety enhancer oat β-glucan for combating obesity, which was incorporated into the NHMRC Australian Dietary Guidelines 2011, Food Standards ANZ 2015, and used by Uncle Toby’s for product development, (c) the site of the antipsychotic drug responsible for obesity, leading to new drug developments, and (d) that mental illness patients with diabetes have worse cognitive functioning, requiring combination therapy. He has published 253 research articles, with over 13,200 citations and supervised 26 PhD students. He is Director of Translational Neuroscience Centre at UOW and Leader of Mental Health theme in IHMRI 2019.

Career Summary:
After the completion of a PhD at the University of New South Wales Australia (UNSW), Prof Huang received 3 years of postdoctoral training in the Schools of Psychology and Pathology at UNSW. He then joined the University of Wollongong (UOW) as a Lecturer in October, 1995. He was awarded Doctor of Science (DSc) in 2012. He initiated and established the Center for Translational Neuroscience at UOW studying the central control of energy balance associated with obesity and neuropharmacology of antipsychotic drugs since 1999. He joined the Illawarra Health and Medical Research Institute (IHMRI) in 2010 and was subsequently appointed as Foundation Scientific Director of the Metabolic Theme from September 2010 to June 2012. He was Acting Executive Director of IHMRI from Nov 2012 to June 2013 and Deputy Executive Director (Scientific) from July 2011 to Jan 2016 and  Theme Leader of the Mental Health and Ageing Brain from 2017 to 2019. He received the Vice-Chancellor’s Research Excellence Award for Senior Researcher of the Year 2014. From 2017 to now, he is Theme Leader for Mental Health and Ageing Brain theme in IHMRI.

Disciplinary expertise: He has broad knowledge from cell and animal based research to clinical research and biostatistics. His expertise is in neuropharmacology, metabolism, molecular nutrition, and clinical psychiatric studies. His research investigates the mechanisms of neurotransmission and intracellular signal transduction using cell and rodent models, computational modelling, and clinical studies. His publications reflect his expertise in neuropharmacology, the mechanism of antipsychotic drug action and molecular nutrition for obesity, metabolic disorders and schizophrenia. 

Top Publications


Research Overview


  • Publications: He has published 253 full research papers, 3 books, 9 book chapters and attracted more than 12,999 citations (Google Scholar 2020). He has an h-index of 57, with 24 publications having over 100 cites – He received an average 912 cites per year over the last 10 years, and 1,116 cites per year for the last 5 years (GS). In the last 10 years, he published 162 primary research papers, of which 94 are in the top 10% of journals (SJR), and 22 are in the top 10% for number of citations, for his field, worldwide (SciVal)–reflecting the impact his research program has had on the field.

    Collaborations: He has an extensive collaboration network with world leading research laboratories both nationally and internationally. This enables him to access advanced knowledge, skills, equipment, and databases, to receive international and industry research funding, and to attract highly talented HDR students and postdoctoral research fellows.

    Supervision and mentoring of Postdoctoral Fellows and Postgraduate Students: He has successfully mentored postgraduate completions comprising 12 PhD and 4 Masters students, as well as 4 Honours students in the last 5 years. Over his research career, He has mentored 14 postdoctoral fellows, 8 international visiting fellows and 6 research assistants. He received the University of Wollongong Vice Chancellor’s Excellence in Research Supervision Award in 2010.

    Contribution to NHMRC, ARC and Peer review involvement: He has been an external assessor reviewing various project grants including for NHMRC from 1997 to present, IHMRI from 2012 to 2015, Schizophrenia Research Institute from 2010 to 2015, Medical Research Commercialisation Fund from 2012 to 2013, ARC Future Fellowship in 2012 and Diabetes Australia 2011-2013. He is Editorial Board Member for Frontier Neuroscience, International J of Obesity, Basic Sciences of Medicine, and a reviewer for more than 20 leading international referred journals.

Available for Collaborative Projects

Selected Publications


Investigator On


Impact Story


Potential Supervision Topics


  • 1. The mechanism of anti-psychotic drug action for schizophrenia;
    2. Neural branching repair for a better neural connectivity and networking;
    3. How to use flowcytometry and cell imaging skills to study pathological based cells

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy (Integrated) The Role of DISC1 on regulating neurite outgrowth through mediating signalling pathway induced by D2/D1 receptor activation in the Prefrontal cortical Neurons Zheng, Peng
    Doctor of Philosophy The role of olanzapine-induced autophagy in the hypothalamic energy regulatory pathwsay Boz, Zehra
    Doctor of Philosophy (Integrated) The role of D2R and NR2B interaction in neurite regulation Xie, Yuanyi
    Doctor of Philosophy Development of Innovative Functionalized Colored NanoMaterials in Lateral Flow Biosensor Applications for Disease-Related Biomarkers Qin, Chunyan
    Doctor of Philosophy Prevention of brain inflammation affecting neural connectivity in schizophrenia Dongol, Anjila
    Doctor of Philosophy Advanced nanoceramic composite for health protection applications. Rehman, Yaser
    Doctor of Philosophy (Integrated) The Molecular Mechanism of Microbiota-Gut-Brain Axis Influenced by Dietary Fibre Types Wang, Zhizhen
    Master of Philosophy -SMAH Assessment of a novel therapeutic drug to protect neural impairment and prevent cognitive decline in type 2 diabetes Chen, Xi
    Doctor of Philosophy An Investigation of the Kynurenine Pathway in Major Depression Brown, Samara
    Doctor of Philosophy The effect of different beneficial compounds from the cannabis plant on psychotic and cognitive behaviours and the underlying mechanisms Jimenez Naranjo, Carlos

Education And Training


Keywords


  • neuropharmacology, molecular nutrition, mental health, schizophrenia, type 2 diabetes, obesity, antipsychotic drug

Full Name


  • Xu-Feng Huang

Mailing Address


  • Room 305 Illawarra Health and Medical Research Institute and University of Wollongong

    North field avenue

    Wollongong

    NSW

    2500

    Australia

Geographic Location


Located In Facility


Top Publications


Research Overview


  • Publications: He has published 253 full research papers, 3 books, 9 book chapters and attracted more than 12,999 citations (Google Scholar 2020). He has an h-index of 57, with 24 publications having over 100 cites – He received an average 912 cites per year over the last 10 years, and 1,116 cites per year for the last 5 years (GS). In the last 10 years, he published 162 primary research papers, of which 94 are in the top 10% of journals (SJR), and 22 are in the top 10% for number of citations, for his field, worldwide (SciVal)–reflecting the impact his research program has had on the field.

    Collaborations: He has an extensive collaboration network with world leading research laboratories both nationally and internationally. This enables him to access advanced knowledge, skills, equipment, and databases, to receive international and industry research funding, and to attract highly talented HDR students and postdoctoral research fellows.

    Supervision and mentoring of Postdoctoral Fellows and Postgraduate Students: He has successfully mentored postgraduate completions comprising 12 PhD and 4 Masters students, as well as 4 Honours students in the last 5 years. Over his research career, He has mentored 14 postdoctoral fellows, 8 international visiting fellows and 6 research assistants. He received the University of Wollongong Vice Chancellor’s Excellence in Research Supervision Award in 2010.

    Contribution to NHMRC, ARC and Peer review involvement: He has been an external assessor reviewing various project grants including for NHMRC from 1997 to present, IHMRI from 2012 to 2015, Schizophrenia Research Institute from 2010 to 2015, Medical Research Commercialisation Fund from 2012 to 2013, ARC Future Fellowship in 2012 and Diabetes Australia 2011-2013. He is Editorial Board Member for Frontier Neuroscience, International J of Obesity, Basic Sciences of Medicine, and a reviewer for more than 20 leading international referred journals.

Selected Publications


Investigator On


Impact Story


Potential Supervision Topics


  • 1. The mechanism of anti-psychotic drug action for schizophrenia;
    2. Neural branching repair for a better neural connectivity and networking;
    3. How to use flowcytometry and cell imaging skills to study pathological based cells

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy (Integrated) The Role of DISC1 on regulating neurite outgrowth through mediating signalling pathway induced by D2/D1 receptor activation in the Prefrontal cortical Neurons Zheng, Peng
    Doctor of Philosophy The role of olanzapine-induced autophagy in the hypothalamic energy regulatory pathwsay Boz, Zehra
    Doctor of Philosophy (Integrated) The role of D2R and NR2B interaction in neurite regulation Xie, Yuanyi
    Doctor of Philosophy Development of Innovative Functionalized Colored NanoMaterials in Lateral Flow Biosensor Applications for Disease-Related Biomarkers Qin, Chunyan
    Doctor of Philosophy Prevention of brain inflammation affecting neural connectivity in schizophrenia Dongol, Anjila
    Doctor of Philosophy Advanced nanoceramic composite for health protection applications. Rehman, Yaser
    Doctor of Philosophy (Integrated) The Molecular Mechanism of Microbiota-Gut-Brain Axis Influenced by Dietary Fibre Types Wang, Zhizhen
    Master of Philosophy -SMAH Assessment of a novel therapeutic drug to protect neural impairment and prevent cognitive decline in type 2 diabetes Chen, Xi
    Doctor of Philosophy An Investigation of the Kynurenine Pathway in Major Depression Brown, Samara
    Doctor of Philosophy The effect of different beneficial compounds from the cannabis plant on psychotic and cognitive behaviours and the underlying mechanisms Jimenez Naranjo, Carlos

Education And Training


Keywords


  • neuropharmacology, molecular nutrition, mental health, schizophrenia, type 2 diabetes, obesity, antipsychotic drug

Full Name


  • Xu-Feng Huang

Mailing Address


  • Room 305 Illawarra Health and Medical Research Institute and University of Wollongong

    North field avenue

    Wollongong

    NSW

    2500

    Australia

Geographic Location


Located In Facility


Geographic Focus