Mitchell, Todd

Top Publications

Year	Title
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published in Analytical Chemistry
2010	Advances in mass spectrometry for lipidomics Published in Annual Review of Analytical Chemistry
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published in Progress in Lipid Research
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published in Nature Communications
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published in The Analyst

Research Areas

Available as Research Supervisor

Selected Publications

Journal Article

Year	Title
2021	Next-generation derivatization reagents optimized for enhanced product ion formation in photodissociation-mass spectrometry of fatty acids Published In Analyst
2021	Profiling of non-polar lipids in tears of contact lens wearers during the day Published In Experimental Eye Research
2021	Tau is truncated in five regions of the normal adult human brain Published In International Journal of Molecular Sciences
2021	The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids Published In Mechanisms of Ageing and Development
2020	Cholesteryl ester levels are elevated in the caudate and putamen of Huntington¿s disease patients Published In Scientific Reports
2020	Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people Published In Schizophrenia Research
2020	Corrigendum: Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial (Frontiers in Psychiatry, (2019), 10, 10.3389/fpsyt.2019.00393) Published In Frontiers in Psychiatry
2020	Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation Published In International Journal for Parasitology
2020	Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives Published In Rapid Communications in Mass Spectrometry
2020	Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis Published In Schizophrenia Research
2019	Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry Published In Journal of Lipid Research
2019	Biobanking for metabolomics and lipidomics in precision medicine Published In Clinical Chemistry
2019	Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis Published In Journal of the American Society for Mass Spectrometry
2019	Honey bee caste lipidomics in relation to life-history stage and the long life of the queen Published In The Journal of Experimental Biology
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry
2019	Lipidomics needs more standardization Published In Nature Metabolism
2019	Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation Published In Journal of the American Society for Mass Spectrometry
2019	Reaction of ionised steryl esters with ozone in the gas phase Published In Chemistry and Physics of Lipids
2019	Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84 Published In The FASEB Journal
2019	Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial. Published In Frontiers in psychiatry
2018	A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index Published In Lipids
2018	Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids Published In Analytical Chemistry
2018	Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation Published In International Journal of Mass Spectrometry
2018	Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration Published In British Journal of Biomedical Science
2018	Distribution of Glycerophospholipids in the Adult Human Lens Published In Biomolecules
2018	Increasing Acyl CoA thioesterase activity alters phospholipid profle without effect on insulin action in skeletal muscle of rats Published In Scientific Reports
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research
2018	Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses Published In Analytical Chemistry
2017	Advances and unresolved challenges in the structural characterization of isomeric lipids Published In Analytical Biochemistry
2017	Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains Published In Scientific Reports
2017	High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales Published In Analytical Chemistry
2017	Radical Generation from the Gas-Phase Activation of Ionized Lipid Ozonides Published In Journal of the American Society for Mass Spectrometry
2017	The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Published In British Journal of Haematology
2017	The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging Published In GeroScience
2016	A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage Published In PLoS One
2016	Annexin A6 regulates interleukin-2-mediated T-cell proliferation Published In Immunology and Cell Biology
2016	Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum Published In Malaria Journal
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry
2016	Influence of Meibomian gland expression methods on human lipid analysis results Published In The Ocular Surface
2016	Intersubject and interday variability in human tear and meibum lipidomes: a pilot study Published In The Ocular Surface
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^-/- mice Published In Journal of Immunology
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^−/− mice Published In Journal of Immunology
2016	Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species Published In BBA: Molecular and Cell Biology of Lipids
2016	Sequential collision- and ozone-induced dissociation enables assignment of relative acyl chain position in triacylglycerols Published In Analytical Chemistry
2015	A rapid ambient ionization-mass spectrometry approach to monitoring the relative abundance of isomeric glycerophospholipids Published In Scientific Reports
2015	Combining liquid chromatography with ozone-induced dissociation for the separation and identification of phosphatidylcholine double bond isomers Published In Analytical and Bioanalytical Chemistry
2015	Correction: No turnover in lens lipids for the entire human lifespan. Published In eLife
2015	Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespan Published In Lipids
2015	Disparate metabolic response to fructose feeding between different mouse strains Published In Scientific Reports
2015	Dissociation of proton-bound complexes reveals geometry and arrangement of double bonds in unsaturated lipids Published In International Journal of Mass Spectrometry
2015	Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease Published In Neurobiology of Aging
2015	No turnover in lens lipids for the entire human lifespan Published In eLife
2015	Of mice, pigs and humans: an analysis of mitochondrial phospholipids from mammals with very different maximal lifespans Published In Experimental Gerontology
2015	Separation and identification of phosphatidylcholine regioisomers by combining liquid chromatography with a fusion of collision-and ozone-induced dissociation Published In European Journal of Mass Spectrometry
2015	Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line Published In PLoS One
2015	The effects of contact lens wear on concentration of phospholipids in the tear film Published In Contact Lens and Anterior Eye
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published In Nature Communications
2014	A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism Published In Nutrients
2014	Characterisation of sphingolipids in the human lens by thin layer chromatography-desorption electrospray ionisation mass spectrometry Published In BBA: Molecular and Cell Biology of Lipids
2014	Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry Published In Journal of Lipid Research
2014	Clinical and biochemical tear lipid parameters in contact lens wearers Published In Optometry and Vision Science
2014	Comparison of tear lipid profile among basal, reflex, and flush tear samples Published In Optometry and Vision Science
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published In The Analyst
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids
2013	Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry Published In The Analyst
2013	Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment Published In Diabetologia
2013	Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle Published In Journal of Lipid Research
2013	High-dose mushroom increases hepatic accumulation of triacylglycerol in rats fed with high-fat diet Published In Annals of Nutrition and Metabolism: European journal of nutrition, metabolic diseases and dietetics
2013	Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding Published In Diabetologia
2013	Ozone-induced dissociation of conjugated lipids reveals significant reaction rate enhancements and characteristic odd-electron product ions Published In Journal of the American Society for Mass Spectrometry
2013	Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives Published In Rapid Communications in Mass Spectrometry
2013	Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-Mass spectrometry Published In Investigative Ophthalmology and Visual Science
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published In Progress in Lipid Research
2012	Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes Published In Diabetologia
2012	Differentiation of complex lipid isomers by radical-directed dissociation mass spectrometry Published In Analytical Chemistry
2012	Direct detection of additives and degradation products from polymers by liquid extraction surface analysis employing chip-based nanospray mass spectrometry Published In Rapid Communications in Mass Spectrometry
2012	Direct lipid profiling of single cells from inkjet printed microarrays Published In Analytical Chemistry
2012	Instability of the cellular lipidome with age Published In Age
2012	Phospholipid peroxidation: lack of effect of fatty acid pairing Published In Lipids
2012	Time to face the fats: What can mass spectrometry reveal about the structure of lipids and their interactions with proteins? Published In Journal of the American Society for Mass Spectrometry
2012	Using ambient ozone for assignment of double bond position in unsaturated lipids Published In The Analyst
2011	Analysis of unsaturated lipids by ozone-induced dissociation Published In BBA: Molecular and Cell Biology of Lipids
2011	Fatty acid uptake and incorporation into phospholipids in the rat lens. Published In Investigative Ophthalmology and Visual Science
2011	Identification of phospholipids in human meibum by nano-electrospray ionisation tandem mass spectrometry Published In Experimental Eye Research
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One
2011	The ω-3 and ω-6 fats in meals: a proposal for a simple new label Published In Nutrition
2011	Unsuccessful ageing: dramatic changes to the human lens lipidome with age Published In Clinical and Experimental Ophthalmology
2010	Advances in mass spectrometry for lipidomics Published In Annual Review of Analytical Chemistry
2010	Anti-inflammatory effects of apolipoprotein A-I in the rabbit Published In Atherosclerosis
2010	Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution Published In Investigative Ophthalmology and Visual Science
2010	Imaging of human lens lipids by desorption electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry
2010	Lipid analysis of phagosomal membranes Published In Journal of the American Society for Mass Spectrometry
2010	Ozone-induced dissociation on a modified tandem linear ion-trap: observations of different reactivity for isomeric lipids Published In Journal of the American Society for Mass Spectrometry
2010	Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors Published In Endocrinology
2010	Sphingolipid distribution changes with age in the human lens Published In Journal of Lipid Research
2010	The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet Published In International Journal of Molecular Sciences
2010	α- and β-crystallins modulate the head group order of human lens membranes during aging Published In Investigative Ophthalmology and Visual Science
2009	Caveolin-1-dependent and -independent membrane domains Published In Journal of Lipid Research
2009	Identification of abundant alkyl ether glycerophospholipids in the human lens by tandem mass spectrometry techniques Published In Analytical Chemistry
2009	Identification of double bond position in lipids: from GC to OzID Published In Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2009	Online ozonolysis methods for the determination of double bond position in unsaturated lipids Published In Methods in Molecular Biology
2009	Tracking the glycerophospholipid distribution of docosahexaenoic acid by shotgun lipidomics Published In Methods in Molecular Biology
2008	Human lens lipids differ markedly from those of commonly used experimental animals Published In BBA: Molecular and Cell Biology of Lipids
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published In Analytical Chemistry
2008	Phospholipid composition of the rat lens is independent of diet Published In Experimental Eye Research
2008	Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: an analysis of kidney and brain Published In The Journal of Experimental Biology
2007	Differences in membrane acyl phospholipid composition between an endothermic mammal and an ectothermic reptile are not limited to any phospholipid class Published In The Journal of Experimental Biology
2007	Dilinoleoyl-Phosphatidic Acid Mediates Reduced IRS-1 Tyrosine Phosphorylation In Rat Skeletal Muscle Cells and Mouse Muscle Published In Diabetologia
2007	Elucidation of double bond position in unsaturated lipids by ozone electrospray ionization mass spectrometry Published In Analytical Chemistry
2007	Interactions between apolipoprotein A-1 and plasma membrane lipid domains, leading to phospholipid and cholesterol export Published In Chemistry and Physics of Lipids
2007	Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): A comparative study using shotgun lipidomics Published In Experimental Gerontology

Chapter

Year	Title
2012	Structural lipidomics Published In Lipidomics: Technologies and Applications
2009	Tracking the glycerophospholipid distribution of docosahexaenoic acid by shotgun lipidomics Published In Lipidomics: methods and protocols

Conference Paper

Year	Title
2012	Membrane lipids in human lenses and age Published In ISER 2012: XX Biennial Meeting of the International society for Eye Research - Abstracts
2010	Imaging of abundant human lens lipids by desorption electrospray ionization mass spectrometry Published In 58th ASMS Conference on Mass Spectrometry
2010	Lenses, lipids and life: understanding age-related alterations in fibre cell membranes Published In XIX Biennial Meeting of the International Society for Eye Research
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
2010	Ozone induced dissociation for lipodomics workflows Published In 58th ASMS Conference on Mass Spectrometry
2010	Phospholipids in tears, contact lenses and meibum? Published In 6th International Conference on the Tear Film and Ocular Surface: Basic Science and Clinical Relevance
2010	Quantification of triacylglycerols regioisomers present in lipid extracts by CID and CID/OzID techniques Published In 58th ASMS Conference on Mass Spectrometry
2010	The lipid composition of the human lens nucleus alters substantially with age Published In ISER 2010: XIX Biennial Meeting of the International Society for Eye Research, Montreal, Canada, 2010
2009	A down under approach to top-down lipidomics: towards the full structural characterisation of lipids by mass spectrometry Published In Frontier Lipidology: Lipidomics in Health and Disease
2009	Alterations in human lens membrane phospholipids with age Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Apathetic amphipathic? Searching for phospholipid biomarkers of dry eye Published In Solving Dry Eye: An International Exchange
2009	Are lipidomics analyses greatly underestimating lipid diversity? Published In 21st ASMS Sanibel Conference on Mass Spectrometry
2009	Big fat tears: a mass spectrometric investigation of phospholipids in tears and contact lens deposits Published In Solving dry eye: an international exchange
2009	Electrospray ionisation mass spectrometry reveals age-related alterations in human lens phospholipid composition Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Human lens lipids: their structure, turnover and distribution Published In Frontier Lipidology: Lipidomics in Health and Disease
2009	Lipid MS: observations from the lens Published In ACT Mass Spectrometry Symposium 2009
2009	Lipid analysis of phagosomal membranes Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Lipids in tears and on contact lenses: a shotgun lipidomic analysis Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Lisofylline and myriocin improve insulin action in mice fed diets rich in either polyunsaturated or saturated fats Published In Keystone Symposia on Type 2 Diabetes and Insulin Resistance
2009	New insights into the human lens through multi-faceted lipid mass spectrometry Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Ozone induced dissociation in structure elucidation Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Structural characterisation of triacylglycerols (TAGs) prsent in very low density lipoprotein by ozone-induced dissociation (OzID) Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	The search for a barrier in the middle aged human lens: visualising lipid distribution by MALDI-imaging Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Unusual reaction product from the gas-phase ozonolysis of an unsaturated phosphatidylethanolamine sodium adduct: possible insights into the ozonolysis mechanism Published In ANZSMS 22: 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Visualizing the sphingolipid distribution of the human lens Published In 18th International Mass Spectrometry Conference
2007	Ceramides and diet induced insulin resistance in rats: new insights from ESI-MS Published In Australian and New Zealand Society for Mass Spectrometry 21st Conference
2007	Heads or tails? What is the important link between membrane phospholipids, body mass and metabolism? Published In Australian and New Zealand Society for Mass Spectrometry 21st Conference

Investigator On

Year	Title
2019 - 2021	Pluses and minuses of lipid mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018	Developing next generation mass spectrometry imaging with isomer resolution Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2018	NSW molecular analysis platform: FTICR mass spectrometer and CHN&S analyser Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012 - 2016	Lipidomics of vision Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2011 - 2016	Development of Ozone-Induced Dissociation for Lipidomics Workflows Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2015	Developing next generation technologies for unmasking the lipidome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012 - 2015	New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2013	Advanced High Resolution Mass Spectrometer for Collaborative Proteomic and Lipidomics Research Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Ancient proteins and disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Microbial infestation of pre-painted steel building materials: chemical and microbial characterization, model development and control strategies Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011	Targeting ceramide metabolism to improve lipi-induced insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Fat for life: using accelerator mass spectrometry to determine the lifespan of human lens lipids Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2009	New methods to complete the lipidomics puzzle: revealing the structural diversity of lipids by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Understanding sphingolipid mediators of insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Region-Specific Shifts in the Neural Lipid Chemistry of Advanced Huntingtons Disease
Doctor of Philosophy	The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease	Balez, Rachelle
Doctor of Philosophy	The role of long chain omega-3 fatty acids in modifying muscle fatigue and soreness after damaging exercise.	Anthony, Ryan
Doctor of Philosophy	Laser Techniques to Detect and Identify Protonation Isomers	Marlton, Samuel
Doctor of Philosophy	Lifestyle Interventions to Improve Risk Factors for Cardiovascular Disease in Individuals with and at Risk of Type 2 Diabetes	Chang, Courtney
Doctor of Philosophy	Mass Spectrometry Imaging of Dynamic Lipid Metabolism in Biological Tissues	Michael, Jesse

Orcid Id

http://orcid.org/0000-0002-1372-9963 (confirmed)

Scopus Id

7402174965

Top Publications

Year	Title
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published in Analytical Chemistry
2010	Advances in mass spectrometry for lipidomics Published in Annual Review of Analytical Chemistry
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published in Progress in Lipid Research
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published in Nature Communications
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published in The Analyst

Research Areas

Selected Publications

Journal Article

Year	Title
2021	Next-generation derivatization reagents optimized for enhanced product ion formation in photodissociation-mass spectrometry of fatty acids Published In Analyst
2021	Profiling of non-polar lipids in tears of contact lens wearers during the day Published In Experimental Eye Research
2021	Tau is truncated in five regions of the normal adult human brain Published In International Journal of Molecular Sciences
2021	The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids Published In Mechanisms of Ageing and Development
2020	Cholesteryl ester levels are elevated in the caudate and putamen of Huntington¿s disease patients Published In Scientific Reports
2020	Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people Published In Schizophrenia Research
2020	Corrigendum: Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial (Frontiers in Psychiatry, (2019), 10, 10.3389/fpsyt.2019.00393) Published In Frontiers in Psychiatry
2020	Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation Published In International Journal for Parasitology
2020	Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives Published In Rapid Communications in Mass Spectrometry
2020	Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis Published In Schizophrenia Research
2019	Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry Published In Journal of Lipid Research
2019	Biobanking for metabolomics and lipidomics in precision medicine Published In Clinical Chemistry
2019	Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis Published In Journal of the American Society for Mass Spectrometry
2019	Honey bee caste lipidomics in relation to life-history stage and the long life of the queen Published In The Journal of Experimental Biology
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry
2019	Lipidomics needs more standardization Published In Nature Metabolism
2019	Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation Published In Journal of the American Society for Mass Spectrometry
2019	Reaction of ionised steryl esters with ozone in the gas phase Published In Chemistry and Physics of Lipids
2019	Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84 Published In The FASEB Journal
2019	Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial. Published In Frontiers in psychiatry
2018	A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index Published In Lipids
2018	Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids Published In Analytical Chemistry
2018	Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation Published In International Journal of Mass Spectrometry
2018	Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration Published In British Journal of Biomedical Science
2018	Distribution of Glycerophospholipids in the Adult Human Lens Published In Biomolecules
2018	Increasing Acyl CoA thioesterase activity alters phospholipid profle without effect on insulin action in skeletal muscle of rats Published In Scientific Reports
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research
2018	Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses Published In Analytical Chemistry
2017	Advances and unresolved challenges in the structural characterization of isomeric lipids Published In Analytical Biochemistry
2017	Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains Published In Scientific Reports
2017	High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales Published In Analytical Chemistry
2017	Radical Generation from the Gas-Phase Activation of Ionized Lipid Ozonides Published In Journal of the American Society for Mass Spectrometry
2017	The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Published In British Journal of Haematology
2017	The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging Published In GeroScience
2016	A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage Published In PLoS One
2016	Annexin A6 regulates interleukin-2-mediated T-cell proliferation Published In Immunology and Cell Biology
2016	Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum Published In Malaria Journal
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry
2016	Influence of Meibomian gland expression methods on human lipid analysis results Published In The Ocular Surface
2016	Intersubject and interday variability in human tear and meibum lipidomes: a pilot study Published In The Ocular Surface
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^-/- mice Published In Journal of Immunology
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^−/− mice Published In Journal of Immunology
2016	Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species Published In BBA: Molecular and Cell Biology of Lipids
2016	Sequential collision- and ozone-induced dissociation enables assignment of relative acyl chain position in triacylglycerols Published In Analytical Chemistry
2015	A rapid ambient ionization-mass spectrometry approach to monitoring the relative abundance of isomeric glycerophospholipids Published In Scientific Reports
2015	Combining liquid chromatography with ozone-induced dissociation for the separation and identification of phosphatidylcholine double bond isomers Published In Analytical and Bioanalytical Chemistry
2015	Correction: No turnover in lens lipids for the entire human lifespan. Published In eLife
2015	Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespan Published In Lipids
2015	Disparate metabolic response to fructose feeding between different mouse strains Published In Scientific Reports
2015	Dissociation of proton-bound complexes reveals geometry and arrangement of double bonds in unsaturated lipids Published In International Journal of Mass Spectrometry
2015	Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease Published In Neurobiology of Aging
2015	No turnover in lens lipids for the entire human lifespan Published In eLife
2015	Of mice, pigs and humans: an analysis of mitochondrial phospholipids from mammals with very different maximal lifespans Published In Experimental Gerontology
2015	Separation and identification of phosphatidylcholine regioisomers by combining liquid chromatography with a fusion of collision-and ozone-induced dissociation Published In European Journal of Mass Spectrometry
2015	Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line Published In PLoS One
2015	The effects of contact lens wear on concentration of phospholipids in the tear film Published In Contact Lens and Anterior Eye
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published In Nature Communications
2014	A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism Published In Nutrients
2014	Characterisation of sphingolipids in the human lens by thin layer chromatography-desorption electrospray ionisation mass spectrometry Published In BBA: Molecular and Cell Biology of Lipids
2014	Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry Published In Journal of Lipid Research
2014	Clinical and biochemical tear lipid parameters in contact lens wearers Published In Optometry and Vision Science
2014	Comparison of tear lipid profile among basal, reflex, and flush tear samples Published In Optometry and Vision Science
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published In The Analyst
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids
2013	Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry Published In The Analyst
2013	Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment Published In Diabetologia
2013	Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle Published In Journal of Lipid Research
2013	High-dose mushroom increases hepatic accumulation of triacylglycerol in rats fed with high-fat diet Published In Annals of Nutrition and Metabolism: European journal of nutrition, metabolic diseases and dietetics
2013	Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding Published In Diabetologia
2013	Ozone-induced dissociation of conjugated lipids reveals significant reaction rate enhancements and characteristic odd-electron product ions Published In Journal of the American Society for Mass Spectrometry
2013	Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives Published In Rapid Communications in Mass Spectrometry
2013	Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-Mass spectrometry Published In Investigative Ophthalmology and Visual Science
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published In Progress in Lipid Research
2012	Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes Published In Diabetologia
2012	Differentiation of complex lipid isomers by radical-directed dissociation mass spectrometry Published In Analytical Chemistry
2012	Direct detection of additives and degradation products from polymers by liquid extraction surface analysis employing chip-based nanospray mass spectrometry Published In Rapid Communications in Mass Spectrometry
2012	Direct lipid profiling of single cells from inkjet printed microarrays Published In Analytical Chemistry
2012	Instability of the cellular lipidome with age Published In Age
2012	Phospholipid peroxidation: lack of effect of fatty acid pairing Published In Lipids
2012	Time to face the fats: What can mass spectrometry reveal about the structure of lipids and their interactions with proteins? Published In Journal of the American Society for Mass Spectrometry
2012	Using ambient ozone for assignment of double bond position in unsaturated lipids Published In The Analyst
2011	Analysis of unsaturated lipids by ozone-induced dissociation Published In BBA: Molecular and Cell Biology of Lipids
2011	Fatty acid uptake and incorporation into phospholipids in the rat lens. Published In Investigative Ophthalmology and Visual Science
2011	Identification of phospholipids in human meibum by nano-electrospray ionisation tandem mass spectrometry Published In Experimental Eye Research
2011	Lipid pathway alterations in Parkinson's Disease primary visual cortex Published In PLoS One
2011	The ω-3 and ω-6 fats in meals: a proposal for a simple new label Published In Nutrition
2011	Unsuccessful ageing: dramatic changes to the human lens lipidome with age Published In Clinical and Experimental Ophthalmology
2010	Advances in mass spectrometry for lipidomics Published In Annual Review of Analytical Chemistry
2010	Anti-inflammatory effects of apolipoprotein A-I in the rabbit Published In Atherosclerosis
2010	Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution Published In Investigative Ophthalmology and Visual Science
2010	Imaging of human lens lipids by desorption electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry
2010	Lipid analysis of phagosomal membranes Published In Journal of the American Society for Mass Spectrometry
2010	Ozone-induced dissociation on a modified tandem linear ion-trap: observations of different reactivity for isomeric lipids Published In Journal of the American Society for Mass Spectrometry
2010	Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors Published In Endocrinology
2010	Sphingolipid distribution changes with age in the human lens Published In Journal of Lipid Research
2010	The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet Published In International Journal of Molecular Sciences
2010	α- and β-crystallins modulate the head group order of human lens membranes during aging Published In Investigative Ophthalmology and Visual Science
2009	Caveolin-1-dependent and -independent membrane domains Published In Journal of Lipid Research
2009	Identification of abundant alkyl ether glycerophospholipids in the human lens by tandem mass spectrometry techniques Published In Analytical Chemistry
2009	Identification of double bond position in lipids: from GC to OzID Published In Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2009	Online ozonolysis methods for the determination of double bond position in unsaturated lipids Published In Methods in Molecular Biology
2009	Tracking the glycerophospholipid distribution of docosahexaenoic acid by shotgun lipidomics Published In Methods in Molecular Biology
2008	Human lens lipids differ markedly from those of commonly used experimental animals Published In BBA: Molecular and Cell Biology of Lipids
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published In Analytical Chemistry
2008	Phospholipid composition of the rat lens is independent of diet Published In Experimental Eye Research
2008	Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: an analysis of kidney and brain Published In The Journal of Experimental Biology
2007	Differences in membrane acyl phospholipid composition between an endothermic mammal and an ectothermic reptile are not limited to any phospholipid class Published In The Journal of Experimental Biology
2007	Dilinoleoyl-Phosphatidic Acid Mediates Reduced IRS-1 Tyrosine Phosphorylation In Rat Skeletal Muscle Cells and Mouse Muscle Published In Diabetologia
2007	Elucidation of double bond position in unsaturated lipids by ozone electrospray ionization mass spectrometry Published In Analytical Chemistry
2007	Interactions between apolipoprotein A-1 and plasma membrane lipid domains, leading to phospholipid and cholesterol export Published In Chemistry and Physics of Lipids
2007	Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): A comparative study using shotgun lipidomics Published In Experimental Gerontology

Chapter

Year	Title
2012	Structural lipidomics Published In Lipidomics: Technologies and Applications
2009	Tracking the glycerophospholipid distribution of docosahexaenoic acid by shotgun lipidomics Published In Lipidomics: methods and protocols

Conference Paper

Year	Title
2012	Membrane lipids in human lenses and age Published In ISER 2012: XX Biennial Meeting of the International society for Eye Research - Abstracts
2010	Imaging of abundant human lens lipids by desorption electrospray ionization mass spectrometry Published In 58th ASMS Conference on Mass Spectrometry
2010	Lenses, lipids and life: understanding age-related alterations in fibre cell membranes Published In XIX Biennial Meeting of the International Society for Eye Research
2010	Lipidomic assessment of Parkinson's disease brain Published In Australian Neuroscience Society Annual Meeting, Sydney 2010
2010	Ozone induced dissociation for lipodomics workflows Published In 58th ASMS Conference on Mass Spectrometry
2010	Phospholipids in tears, contact lenses and meibum? Published In 6th International Conference on the Tear Film and Ocular Surface: Basic Science and Clinical Relevance
2010	Quantification of triacylglycerols regioisomers present in lipid extracts by CID and CID/OzID techniques Published In 58th ASMS Conference on Mass Spectrometry
2010	The lipid composition of the human lens nucleus alters substantially with age Published In ISER 2010: XIX Biennial Meeting of the International Society for Eye Research, Montreal, Canada, 2010
2009	A down under approach to top-down lipidomics: towards the full structural characterisation of lipids by mass spectrometry Published In Frontier Lipidology: Lipidomics in Health and Disease
2009	Alterations in human lens membrane phospholipids with age Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Apathetic amphipathic? Searching for phospholipid biomarkers of dry eye Published In Solving Dry Eye: An International Exchange
2009	Are lipidomics analyses greatly underestimating lipid diversity? Published In 21st ASMS Sanibel Conference on Mass Spectrometry
2009	Big fat tears: a mass spectrometric investigation of phospholipids in tears and contact lens deposits Published In Solving dry eye: an international exchange
2009	Electrospray ionisation mass spectrometry reveals age-related alterations in human lens phospholipid composition Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Human lens lipids: their structure, turnover and distribution Published In Frontier Lipidology: Lipidomics in Health and Disease
2009	Lipid MS: observations from the lens Published In ACT Mass Spectrometry Symposium 2009
2009	Lipid analysis of phagosomal membranes Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Lipids in tears and on contact lenses: a shotgun lipidomic analysis Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Lisofylline and myriocin improve insulin action in mice fed diets rich in either polyunsaturated or saturated fats Published In Keystone Symposia on Type 2 Diabetes and Insulin Resistance
2009	New insights into the human lens through multi-faceted lipid mass spectrometry Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Ozone induced dissociation in structure elucidation Published In 57th ASMS Conference on Mass Spectrometry and Allied Topics
2009	Structural characterisation of triacylglycerols (TAGs) prsent in very low density lipoprotein by ozone-induced dissociation (OzID) Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	The search for a barrier in the middle aged human lens: visualising lipid distribution by MALDI-imaging Published In 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Unusual reaction product from the gas-phase ozonolysis of an unsaturated phosphatidylethanolamine sodium adduct: possible insights into the ozonolysis mechanism Published In ANZSMS 22: 22nd Australian and New Zealand Society for Mass Spectrometry
2009	Visualizing the sphingolipid distribution of the human lens Published In 18th International Mass Spectrometry Conference
2007	Ceramides and diet induced insulin resistance in rats: new insights from ESI-MS Published In Australian and New Zealand Society for Mass Spectrometry 21st Conference
2007	Heads or tails? What is the important link between membrane phospholipids, body mass and metabolism? Published In Australian and New Zealand Society for Mass Spectrometry 21st Conference

Investigator On

Year	Title
2019 - 2021	Pluses and minuses of lipid mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018	Developing next generation mass spectrometry imaging with isomer resolution Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2018	NSW molecular analysis platform: FTICR mass spectrometer and CHN&S analyser Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012 - 2016	Lipidomics of vision Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2011 - 2016	Development of Ozone-Induced Dissociation for Lipidomics Workflows Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2015	Developing next generation technologies for unmasking the lipidome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012 - 2015	New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2013	Advanced High Resolution Mass Spectrometer for Collaborative Proteomic and Lipidomics Research Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Ancient proteins and disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Microbial infestation of pre-painted steel building materials: chemical and microbial characterization, model development and control strategies Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011	Targeting ceramide metabolism to improve lipi-induced insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Fat for life: using accelerator mass spectrometry to determine the lifespan of human lens lipids Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2009	New methods to complete the lipidomics puzzle: revealing the structural diversity of lipids by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Understanding sphingolipid mediators of insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Region-Specific Shifts in the Neural Lipid Chemistry of Advanced Huntingtons Disease
Doctor of Philosophy	The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease	Balez, Rachelle
Doctor of Philosophy	The role of long chain omega-3 fatty acids in modifying muscle fatigue and soreness after damaging exercise.	Anthony, Ryan
Doctor of Philosophy	Laser Techniques to Detect and Identify Protonation Isomers	Marlton, Samuel
Doctor of Philosophy	Lifestyle Interventions to Improve Risk Factors for Cardiovascular Disease in Individuals with and at Risk of Type 2 Diabetes	Chang, Courtney
Doctor of Philosophy	Mass Spectrometry Imaging of Dynamic Lipid Metabolism in Biological Tissues	Michael, Jesse

Orcid Id

http://orcid.org/0000-0002-1372-9963 (confirmed)

Scopus Id

7402174965

Mitchell, Todd

Associate Professor

Overview

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Available as Research Supervisor

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Selected Publications

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Chapter

Conference Paper

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Investigator On

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Overview

Top Publications

Research Areas

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

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Research Areas