Mitchell, Todd

Top Publications

Year	Title
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published in Analytical Chemistry
2010	Advances in mass spectrometry for lipidomics Published in Annual Review of Analytical Chemistry
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published in Progress in Lipid Research
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published in Nature Communications
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published in The Analyst

Research Areas

Available as Research Supervisor

Selected Publications

Journal Article

Year	Title
2020	Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation Published In International Journal for Parasitology Altmetric
2020	Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives Published In Rapid Communications in Mass Spectrometry Volume 34 Altmetric
2019	Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry Published In Journal of Lipid Research Volume 60 Pages 1968 - 1978 ISSN 0022-2275 Altmetric
2019	Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 2135 - 2143 ISSN 1044-0305 Altmetric
2019	Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people Published In Schizophrenia Research ISSN 0920-9964 Altmetric
2019	Honey bee caste lipidomics in relation to life-history stage and the long life of the queen Published In The Journal of Experimental Biology Volume 222 Pages 207043-1 - 207043-11 ISSN 1477-9145 Altmetric
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry Volume 91 Pages 9901 - 9909 ISSN 0003-2700 Altmetric
2019	Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 1621 - 1630 ISSN 1044-0305 Altmetric
2019	Reaction of ionised steryl esters with ozone in the gas phase Published In Chemistry and Physics of Lipids Volume 221 Pages 198 - 206 ISSN 0009-3084 Altmetric
2019	Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84 Published In The FASEB Journal Volume 33 Pages 12264 - 12276 ISSN 0892-6638 Altmetric
2019	Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis Published In Schizophrenia Research Altmetric
2018	A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index Published In Lipids Volume 53 Pages 1005 - 1015 ISSN 0024-4201 Altmetric
2018	Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids Published In Analytical Chemistry Volume 90 Pages 5343 - 5351 ISSN 0003-2700 Altmetric
2018	Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation Published In International Journal of Mass Spectrometry Volume 431 Pages 27 - 36 ISSN 1387-3806 Altmetric
2018	Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration Published In British Journal of Biomedical Science Volume 25 Pages 40-1 - 40-11 ISSN 0967-4845 Altmetric
2018	Distribution of Glycerophospholipids in the Adult Human Lens Published In Biomolecules Volume 8 Pages 156-1 - 156-6 Altmetric
2018	Increasing Acyl CoA thioesterase activity alters phospholipid profle without effect on insulin action in skeletal muscle of rats Published In Scientific Reports Volume 8 Pages 13967-1 - 13967-12 ISSN 2045-2322 Altmetric
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research Volume 59 Pages 1510 - 1518 ISSN 0022-2275 Altmetric
2018	Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses Published In Analytical Chemistry Volume 90 Pages 1292 - 1300 ISSN 0003-2700 Altmetric
2017	Advances and unresolved challenges in the structural characterization of isomeric lipids Published In Analytical Biochemistry Volume 524 Pages 45 - 55 ISSN 0003-2697 Altmetric
2017	Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains Published In Scientific Reports Volume 7 Pages 13914-1 - 13914-9 ISSN 2045-2322 Altmetric
2017	High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales Published In Analytical Chemistry Volume 89 Pages 4223 - 4229 ISSN 0003-2700 Altmetric
2017	Radical Generation from the Gas-Phase Activation of Ionized Lipid Ozonides Published In Journal of the American Society for Mass Spectrometry Volume 28 Pages 1345 - 1358 ISSN 1044-0305 Altmetric
2017	The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Published In British Journal of Haematology Volume 177 Pages 423 - 440 ISSN 0007-1048 Altmetric
2017	The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging Published In GeroScience Volume 39 Pages 73 - 82 Altmetric
2016	A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage Published In PLoS One Volume 11 Pages 0163972-1 - 0163972-13 ISSN 1932-6203 Altmetric
2016	Annexin A6 regulates interleukin-2-mediated T-cell proliferation Published In Immunology and Cell Biology Volume 94 Pages 543 - 553 ISSN 0818-9641 Altmetric
2016	Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum Published In Malaria Journal Volume 15 Pages 73-1 - 73-13 ISSN 1475-2875 Altmetric
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 30 Pages 2351 - 2359 ISSN 0951-4198 Altmetric
2016	Influence of Meibomian gland expression methods on human lipid analysis results Published In The Ocular Surface Volume 14 Pages 49 - 55 ISSN 1542-0124 Altmetric
2016	Intersubject and interday variability in human tear and meibum lipidomes: a pilot study Published In The Ocular Surface Volume 14 Pages 43 - 48 ISSN 1542-0124 Altmetric
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^−/− mice Published In Journal of Immunology Volume 196 Pages 3993 - 4002 ISSN 0022-1767 Altmetric
2016	Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species Published In BBA: Molecular and Cell Biology of Lipids Volume 1861 Pages 1828 - 1839 ISSN 1388-1981 Altmetric
2016	Sequential collision- and ozone-induced dissociation enables assignment of relative acyl chain position in triacylglycerols Published In Analytical Chemistry Volume 88 Pages 2685 - 2692 ISSN 0003-2700 Altmetric
2015	A rapid ambient ionization-mass spectrometry approach to monitoring the relative abundance of isomeric glycerophospholipids Published In Scientific Reports Volume 5 Pages 9243-1 - 9243-9 ISSN 2045-2322 Altmetric
2015	Combining liquid chromatography with ozone-induced dissociation for the separation and identification of phosphatidylcholine double bond isomers Published In Analytical and Bioanalytical Chemistry Volume 407 Pages 5053 - 5064 ISSN 1618-2642 Altmetric
2015	Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespan Published In Lipids Volume 50 Pages 861 - 872 ISSN 0024-4201 Altmetric
2015	Disparate metabolic response to fructose feeding between different mouse strains Published In Scientific Reports Volume 5 Pages 18474-1 - 18474-13 ISSN 2045-2322 Altmetric
2015	Dissociation of proton-bound complexes reveals geometry and arrangement of double bonds in unsaturated lipids Published In International Journal of Mass Spectrometry Volume 390 Pages 170 - 177 ISSN 1387-3806 Altmetric
2015	Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease Published In Neurobiology of Aging Volume 36 Pages 1659 - 1669 ISSN 0197-4580 Altmetric
2015	No turnover in lens lipids for the entire human lifespan Published In eLife Volume 4 Pages e06003-1 - e06003-7 ISSN 2050-084X Altmetric
2015	Of mice, pigs and humans: an analysis of mitochondrial phospholipids from mammals with very different maximal lifespans Published In Experimental Gerontology Volume 70 Pages 135 - 143 ISSN 0531-5565 Altmetric
2015	Separation and identification of phosphatidylcholine regioisomers by combining liquid chromatography with a fusion of collision-and ozone-induced dissociation Published In European Journal of Mass Spectrometry Volume 21 Pages 191 - 200 ISSN 1469-0667 Altmetric
2015	Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line Published In PLoS One Volume 10 Pages e0128096-1 - e0128096-18 ISSN 1932-6203 Altmetric
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published In Nature Communications Volume 5 Pages 1 - 13 ISSN 2041-1723 Altmetric
2014	A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism Published In Nutrients Volume 6 Pages 650 - 662 Altmetric
2014	Characterisation of sphingolipids in the human lens by thin layer chromatography-desorption electrospray ionisation mass spectrometry Published In BBA: Molecular and Cell Biology of Lipids Volume 1841 Pages 1285 - 1291 ISSN 1388-1981 Altmetric
2014	Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry Published In Journal of Lipid Research Volume 55 Pages 1668 - 1677 ISSN 0022-2275 Altmetric
2014	Clinical and biochemical tear lipid parameters in contact lens wearers Published In Optometry and Vision Science Volume 91 Pages 1384 - 1390 ISSN 1040-5488 Altmetric
2014	Comparison of tear lipid profile among basal, reflex, and flush tear samples Published In Optometry and Vision Science Volume 91 Pages 1391 - 1395 ISSN 1040-5488 Altmetric
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published In The Analyst Volume 139 Pages 204 - 214 ISSN 1364-5528 Altmetric
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 7417 - 7423 ISSN 0146-0404 Altmetric
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids Volume 48 Pages 307 - 318 ISSN 0024-4201 Altmetric
2013	Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry Published In The Analyst Volume 138 Pages 1316 - 1320 ISSN 1364-5528 Altmetric
2013	Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment Published In Diabetologia Volume 56 Pages 2697 - 2701 ISSN 0012-186X Altmetric
2013	Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle Published In Journal of Lipid Research Volume 54 Pages 3322 - 3333 ISSN 0022-2275 Altmetric
2013	High-dose mushroom increases hepatic accumulation of triacylglycerol in rats fed with high-fat diet Published In Annals of Nutrition and Metabolism: European journal of nutrition, metabolic diseases and dietetics Volume 63 Pages 1616 - 1616 ISSN 0250-6807
2013	Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding Published In Diabetologia Volume 56 Pages 1129 - 1139 ISSN 0012-186X Altmetric
2013	Ozone-induced dissociation of conjugated lipids reveals significant reaction rate enhancements and characteristic odd-electron product ions Published In Journal of the American Society for Mass Spectrometry Volume 24 Pages 286 - 296 ISSN 1044-0305 Altmetric
2013	Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives Published In Rapid Communications in Mass Spectrometry Volume 27 Pages 805 - 815 ISSN 0951-4198 Altmetric
2013	Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-Mass spectrometry Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 8027 - 8035 ISSN 0146-0404 Altmetric
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published In Progress in Lipid Research Volume 52 Pages 329 - 353 ISSN 0163-7827 Altmetric
2012	Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes Published In Diabetologia Volume 55 Pages 1156 - 1166 ISSN 0012-186X Altmetric
2012	Differentiation of complex lipid isomers by radical-directed dissociation mass spectrometry Published In Analytical Chemistry Volume 84 Pages 7525 - 7532 ISSN 0003-2700 Altmetric
2012	Direct detection of additives and degradation products from polymers by liquid extraction surface analysis employing chip-based nanospray mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 26 Pages 412 - 418 ISSN 0951-4198 Altmetric
2012	Direct lipid profiling of single cells from inkjet printed microarrays Published In Analytical Chemistry Volume 84 Pages 9679 - 9683 ISSN 0003-2700 Altmetric
2012	Instability of the cellular lipidome with age Published In Age Volume 34 Pages 935 - 947 ISSN 0161-9152 Altmetric
2012	Phospholipid peroxidation: lack of effect of fatty acid pairing Published In Lipids Volume 47 Pages 451 - 460 ISSN 0024-4201 Altmetric
2012	Time to face the fats: What can mass spectrometry reveal about the structure of lipids and their interactions with proteins? Published In Journal of the American Society for Mass Spectrometry Volume 23 Pages 1441 - 1449 ISSN 1044-0305 Altmetric
2012	Using ambient ozone for assignment of double bond position in unsaturated lipids Published In The Analyst Volume 137 Pages 1100 - 1110 ISSN 1364-5528 Altmetric

Investigator On

Year	Title
2019 - 2021	Pluses and minuses of lipid mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2017 - 2019	Understanding sphingolipid mediators of insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Lipidomics of vision Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2011 - 2016	Development of Ozone-Induced Dissociation for Lipidomics Workflows Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2015	Developing next generation technologies for unmasking the lipidome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012 - 2015	New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2013	Advanced High Resolution Mass Spectrometer for Collaborative Proteomic and Lipidomics Research Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Ancient proteins and disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Microbial infestation of pre-painted steel building materials: chemical and microbial characterization, model development and control strategies Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011	Targeting ceramide metabolism to improve lipi-induced insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Fat for life: using accelerator mass spectrometry to determine the lifespan of human lens lipids Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2009	New methods to complete the lipidomics puzzle: revealing the structural diversity of lipids by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Developing next generation mass spectrometry imaging with isomer resolution Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
	NSW molecular analysis platform: FTICR mass spectrometer and CHN&S analyser Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterisation of Alterations in Lipid Pathways in Huntington's Disease. A High-throughput Lipidomic Assessment of Disease Pathways .
Doctor of Philosophy	The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease	Balez, Rachelle
Doctor of Philosophy	Laser Techniques to Detect and Identify Protonation Isomers	Marlton, Samuel
Doctor of Philosophy	Timing Exercise to Attenuate Peak Postprandial Hyperglycemia in Type 2 Diabetes	Chang, Courtney

Orcid Id

http://orcid.org/0000-0002-1372-9963 (confirmed)

Scopus Id

7402174965

Top Publications

Year	Title
2008	Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions Published in Analytical Chemistry
2010	Advances in mass spectrometry for lipidomics Published in Annual Review of Analytical Chemistry
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published in Progress in Lipid Research
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published in Nature Communications
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published in The Analyst

Research Areas

Selected Publications

Journal Article

Year	Title
2020	Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation Published In International Journal for Parasitology Altmetric
2020	Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives Published In Rapid Communications in Mass Spectrometry Volume 34 Altmetric
2019	Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry Published In Journal of Lipid Research Volume 60 Pages 1968 - 1978 ISSN 0022-2275 Altmetric
2019	Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 2135 - 2143 ISSN 1044-0305 Altmetric
2019	Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people Published In Schizophrenia Research ISSN 0920-9964 Altmetric
2019	Honey bee caste lipidomics in relation to life-history stage and the long life of the queen Published In The Journal of Experimental Biology Volume 222 Pages 207043-1 - 207043-11 ISSN 1477-9145 Altmetric
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry Volume 91 Pages 9901 - 9909 ISSN 0003-2700 Altmetric
2019	Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 1621 - 1630 ISSN 1044-0305 Altmetric
2019	Reaction of ionised steryl esters with ozone in the gas phase Published In Chemistry and Physics of Lipids Volume 221 Pages 198 - 206 ISSN 0009-3084 Altmetric
2019	Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84 Published In The FASEB Journal Volume 33 Pages 12264 - 12276 ISSN 0892-6638 Altmetric
2019	Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis Published In Schizophrenia Research Altmetric
2018	A High-Throughput Method for the Analysis of Erythrocyte Fatty Acids and the Omega-3 Index Published In Lipids Volume 53 Pages 1005 - 1015 ISSN 0024-4201 Altmetric
2018	Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids Published In Analytical Chemistry Volume 90 Pages 5343 - 5351 ISSN 0003-2700 Altmetric
2018	Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation Published In International Journal of Mass Spectrometry Volume 431 Pages 27 - 36 ISSN 1387-3806 Altmetric
2018	Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration Published In British Journal of Biomedical Science Volume 25 Pages 40-1 - 40-11 ISSN 0967-4845 Altmetric
2018	Distribution of Glycerophospholipids in the Adult Human Lens Published In Biomolecules Volume 8 Pages 156-1 - 156-6 Altmetric
2018	Increasing Acyl CoA thioesterase activity alters phospholipid profle without effect on insulin action in skeletal muscle of rats Published In Scientific Reports Volume 8 Pages 13967-1 - 13967-12 ISSN 2045-2322 Altmetric
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research Volume 59 Pages 1510 - 1518 ISSN 0022-2275 Altmetric
2018	Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses Published In Analytical Chemistry Volume 90 Pages 1292 - 1300 ISSN 0003-2700 Altmetric
2017	Advances and unresolved challenges in the structural characterization of isomeric lipids Published In Analytical Biochemistry Volume 524 Pages 45 - 55 ISSN 0003-2697 Altmetric
2017	Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains Published In Scientific Reports Volume 7 Pages 13914-1 - 13914-9 ISSN 2045-2322 Altmetric
2017	High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales Published In Analytical Chemistry Volume 89 Pages 4223 - 4229 ISSN 0003-2700 Altmetric
2017	Radical Generation from the Gas-Phase Activation of Ionized Lipid Ozonides Published In Journal of the American Society for Mass Spectrometry Volume 28 Pages 1345 - 1358 ISSN 1044-0305 Altmetric
2017	The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Published In British Journal of Haematology Volume 177 Pages 423 - 440 ISSN 0007-1048 Altmetric
2017	The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging Published In GeroScience Volume 39 Pages 73 - 82 Altmetric
2016	A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage Published In PLoS One Volume 11 Pages 0163972-1 - 0163972-13 ISSN 1932-6203 Altmetric
2016	Annexin A6 regulates interleukin-2-mediated T-cell proliferation Published In Immunology and Cell Biology Volume 94 Pages 543 - 553 ISSN 0818-9641 Altmetric
2016	Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum Published In Malaria Journal Volume 15 Pages 73-1 - 73-13 ISSN 1475-2875 Altmetric
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 30 Pages 2351 - 2359 ISSN 0951-4198 Altmetric
2016	Influence of Meibomian gland expression methods on human lipid analysis results Published In The Ocular Surface Volume 14 Pages 49 - 55 ISSN 1542-0124 Altmetric
2016	Intersubject and interday variability in human tear and meibum lipidomes: a pilot study Published In The Ocular Surface Volume 14 Pages 43 - 48 ISSN 1542-0124 Altmetric
2016	Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^−/− mice Published In Journal of Immunology Volume 196 Pages 3993 - 4002 ISSN 0022-1767 Altmetric
2016	Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species Published In BBA: Molecular and Cell Biology of Lipids Volume 1861 Pages 1828 - 1839 ISSN 1388-1981 Altmetric
2016	Sequential collision- and ozone-induced dissociation enables assignment of relative acyl chain position in triacylglycerols Published In Analytical Chemistry Volume 88 Pages 2685 - 2692 ISSN 0003-2700 Altmetric
2015	A rapid ambient ionization-mass spectrometry approach to monitoring the relative abundance of isomeric glycerophospholipids Published In Scientific Reports Volume 5 Pages 9243-1 - 9243-9 ISSN 2045-2322 Altmetric
2015	Combining liquid chromatography with ozone-induced dissociation for the separation and identification of phosphatidylcholine double bond isomers Published In Analytical and Bioanalytical Chemistry Volume 407 Pages 5053 - 5064 ISSN 1618-2642 Altmetric
2015	Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespan Published In Lipids Volume 50 Pages 861 - 872 ISSN 0024-4201 Altmetric
2015	Disparate metabolic response to fructose feeding between different mouse strains Published In Scientific Reports Volume 5 Pages 18474-1 - 18474-13 ISSN 2045-2322 Altmetric
2015	Dissociation of proton-bound complexes reveals geometry and arrangement of double bonds in unsaturated lipids Published In International Journal of Mass Spectrometry Volume 390 Pages 170 - 177 ISSN 1387-3806 Altmetric
2015	Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease Published In Neurobiology of Aging Volume 36 Pages 1659 - 1669 ISSN 0197-4580 Altmetric
2015	No turnover in lens lipids for the entire human lifespan Published In eLife Volume 4 Pages e06003-1 - e06003-7 ISSN 2050-084X Altmetric
2015	Of mice, pigs and humans: an analysis of mitochondrial phospholipids from mammals with very different maximal lifespans Published In Experimental Gerontology Volume 70 Pages 135 - 143 ISSN 0531-5565 Altmetric
2015	Separation and identification of phosphatidylcholine regioisomers by combining liquid chromatography with a fusion of collision-and ozone-induced dissociation Published In European Journal of Mass Spectrometry Volume 21 Pages 191 - 200 ISSN 1469-0667 Altmetric
2015	Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line Published In PLoS One Volume 10 Pages e0128096-1 - e0128096-18 ISSN 1932-6203 Altmetric
2014	A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite Published In Nature Communications Volume 5 Pages 1 - 13 ISSN 2041-1723 Altmetric
2014	A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism Published In Nutrients Volume 6 Pages 650 - 662 Altmetric
2014	Characterisation of sphingolipids in the human lens by thin layer chromatography-desorption electrospray ionisation mass spectrometry Published In BBA: Molecular and Cell Biology of Lipids Volume 1841 Pages 1285 - 1291 ISSN 1388-1981 Altmetric
2014	Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry Published In Journal of Lipid Research Volume 55 Pages 1668 - 1677 ISSN 0022-2275 Altmetric
2014	Clinical and biochemical tear lipid parameters in contact lens wearers Published In Optometry and Vision Science Volume 91 Pages 1384 - 1390 ISSN 1040-5488 Altmetric
2014	Comparison of tear lipid profile among basal, reflex, and flush tear samples Published In Optometry and Vision Science Volume 91 Pages 1391 - 1395 ISSN 1040-5488 Altmetric
2014	Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics Published In The Analyst Volume 139 Pages 204 - 214 ISSN 1364-5528 Altmetric
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 7417 - 7423 ISSN 0146-0404 Altmetric
2013	An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids Published In Lipids Volume 48 Pages 307 - 318 ISSN 0024-4201 Altmetric
2013	Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry Published In The Analyst Volume 138 Pages 1316 - 1320 ISSN 1364-5528 Altmetric
2013	Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment Published In Diabetologia Volume 56 Pages 2697 - 2701 ISSN 0012-186X Altmetric
2013	Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle Published In Journal of Lipid Research Volume 54 Pages 3322 - 3333 ISSN 0022-2275 Altmetric
2013	High-dose mushroom increases hepatic accumulation of triacylglycerol in rats fed with high-fat diet Published In Annals of Nutrition and Metabolism: European journal of nutrition, metabolic diseases and dietetics Volume 63 Pages 1616 - 1616 ISSN 0250-6807
2013	Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding Published In Diabetologia Volume 56 Pages 1129 - 1139 ISSN 0012-186X Altmetric
2013	Ozone-induced dissociation of conjugated lipids reveals significant reaction rate enhancements and characteristic odd-electron product ions Published In Journal of the American Society for Mass Spectrometry Volume 24 Pages 286 - 296 ISSN 1044-0305 Altmetric
2013	Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives Published In Rapid Communications in Mass Spectrometry Volume 27 Pages 805 - 815 ISSN 0951-4198 Altmetric
2013	Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-Mass spectrometry Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 8027 - 8035 ISSN 0146-0404 Altmetric
2013	Surface analysis of lipids by mass spectrometry: more than just imaging Published In Progress in Lipid Research Volume 52 Pages 329 - 353 ISSN 0163-7827 Altmetric
2012	Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes Published In Diabetologia Volume 55 Pages 1156 - 1166 ISSN 0012-186X Altmetric
2012	Differentiation of complex lipid isomers by radical-directed dissociation mass spectrometry Published In Analytical Chemistry Volume 84 Pages 7525 - 7532 ISSN 0003-2700 Altmetric
2012	Direct detection of additives and degradation products from polymers by liquid extraction surface analysis employing chip-based nanospray mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 26 Pages 412 - 418 ISSN 0951-4198 Altmetric
2012	Direct lipid profiling of single cells from inkjet printed microarrays Published In Analytical Chemistry Volume 84 Pages 9679 - 9683 ISSN 0003-2700 Altmetric
2012	Instability of the cellular lipidome with age Published In Age Volume 34 Pages 935 - 947 ISSN 0161-9152 Altmetric
2012	Phospholipid peroxidation: lack of effect of fatty acid pairing Published In Lipids Volume 47 Pages 451 - 460 ISSN 0024-4201 Altmetric
2012	Time to face the fats: What can mass spectrometry reveal about the structure of lipids and their interactions with proteins? Published In Journal of the American Society for Mass Spectrometry Volume 23 Pages 1441 - 1449 ISSN 1044-0305 Altmetric
2012	Using ambient ozone for assignment of double bond position in unsaturated lipids Published In The Analyst Volume 137 Pages 1100 - 1110 ISSN 1364-5528 Altmetric

Investigator On

Year	Title
2019 - 2021	Pluses and minuses of lipid mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2017 - 2019	Understanding sphingolipid mediators of insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2012 - 2016	Lipidomics of vision Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2011 - 2016	Development of Ozone-Induced Dissociation for Lipidomics Workflows Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2015	Developing next generation technologies for unmasking the lipidome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012 - 2015	New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2013	Advanced High Resolution Mass Spectrometer for Collaborative Proteomic and Lipidomics Research Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Ancient proteins and disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Microbial infestation of pre-painted steel building materials: chemical and microbial characterization, model development and control strategies Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011	Targeting ceramide metabolism to improve lipi-induced insulin resistance Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2010	Fat for life: using accelerator mass spectrometry to determine the lifespan of human lens lipids Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Award
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2009	New methods to complete the lipidomics puzzle: revealing the structural diversity of lipids by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Dilinoleoyl phosphatidic acid as a novel mediator of insulin resistance in muscle Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Developing next generation mass spectrometry imaging with isomer resolution Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
	NSW molecular analysis platform: FTICR mass spectrometer and CHN&S analyser Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterisation of Alterations in Lipid Pathways in Huntington's Disease. A High-throughput Lipidomic Assessment of Disease Pathways .
Doctor of Philosophy	The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease	Balez, Rachelle
Doctor of Philosophy	Laser Techniques to Detect and Identify Protonation Isomers	Marlton, Samuel
Doctor of Philosophy	Timing Exercise to Attenuate Peak Postprandial Hyperglycemia in Type 2 Diabetes	Chang, Courtney

Orcid Id

http://orcid.org/0000-0002-1372-9963 (confirmed)

Scopus Id

7402174965

Mitchell, Todd

Associate Professor

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Available as Research Supervisor

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