Pyne, Stephen G.

Overview

Prof. Stephen Pyne received his BSc (Hons) at Adelaide University (top first class) and his PhD in 1979 from the Australian National University. After postdoctoral research fellowships at Purdue University (with P. Fuchs) and Harvard (with E.J. Corey) he was appointed as a lecturer at the University of Wollongong in 1985. In 1998 he was appointed to Professor. He won the A.J. Birch Medal for excellence in Organic Chemistry Research, from the Organic Division of the Royal Australian Chemical Institute in 2012 and the Archibald Ollé Prize for Chemical Literature in 2015. He has published more than 330 journal publications (h-index 42) in the areas of new methods for the asymmetric synthesis of bioactive molecules; the total synthesis of bioactive natural products, especially alkaloids; the development of novel antibacterial agents against pathological bacteria; and natural products chemistry.

Top Publications

Year	Title
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published in European Journal of Medicinal Chemistry
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published in Angewandte Chemie International Edition
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published in Chemical Communications

Research Areas

Research Overview

The Pyne research group comprises seven PhD students and two Research Associates, some of which are jointly supervised by Prof. Paul Keller and Dr. Chris Hyland. We are working on projects in the following areas:

Discovery of new chemical reactions. Oranoboron reagents and organometallic catalysts are beeing developed for the synthesis of bioactive natural products, drug-like molecules and novel chemical scaffolds for drug discovery (ARC funded with Dr. Chris Hyland). Research Fellow: Dr. Melanie Drew; PhD students: Brendan Bryant, Philip Chevis, Liam Joyce, Srinivas Thadkapally and Quoc Pham.

Discovery and development of new antibacterial agents against pathogenic bacteria (especially Clostridium difficile and Acinetobacter baumannii) (NHMRC funded with Prof. Paul Keller and Assoc. Prof. Haibo Yu). Research Fellow: Dr. Andrew Tague; PhD students: Wendy Cun and Muni Mahadari

Natural products chemistry on traditional medicinal plants from Nigeria and SE Asia. PhD students: Christiana Dawurung, Thanika Promchai and Isaraporn Polbuppha

Selected Publications

Journal Article

Year	Title
2020	A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae) Published In Natural Product Research Altmetric
2020	Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f. Published In Natural Product Research Altmetric
2020	Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis Published In Organic and Biomolecular Chemistry Volume Online First Pages 1 - 19 ISSN 1477-0520 Altmetric
2020	Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea Published In Phytochemistry Volume 179 Altmetric
2020	Styryllactones from Goniothalamus tamirensis Published In Phytochemistry Volume 171 Altmetric
2020	α-Glucosidase Inhibitory Activity of the Extracts and Major Phytochemical Components of Smilax glabra Roxb Published In Natural Products Journal Volume 10 Pages 26 - 32 Altmetric
2020	α-Glucosidase inhibitory and nitric oxide production inhibitory activities of alkaloids isolated from a twig extract of Polyalthia cinnamomea Published In Bioorganic and Medicinal Chemistry Altmetric
2019	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities Published In Natural Product Research Altmetric
2019	1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N -acyliminium ions: Synthetic and computational studies Published In Organic and Biomolecular Chemistry Volume 17 Pages 7025 - 7035 ISSN 1477-0520 Altmetric
2019	A new xanthone and a biphenyl from the flower and twig extracts of Garcinia mckeaniana Published In Natural Product Research Altmetric
2019	A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata Published In Fitoterapia Volume 136 Pages 104175-1 - 104175-6 Altmetric
2019	Alkaloids and styryllactones from Goniothalamus cheliensis Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 157 Pages 8 - 20 ISSN 0031-9422 Altmetric
2019	Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis Published In Journal of Natural Products Volume 82 Pages 283 - 292 ISSN 0163-3864 Altmetric
2019	Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa Published In Journal of Natural Products Volume 82 Pages 2343 - 2348 ISSN 0163-3864 Altmetric
2019	Antidiarrheal activity of some selected Nigerian plants used in traditional medicine Published In Pharmacognosy Research Volume 11 Pages 371 - 377 ISSN 0974-8490 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species Published In Natural Product Research Volume 33 Pages 553 - 556 ISSN 1478-6419 Altmetric
2019	Corrected Structure of Natural Hyacinthacine C 1 via Total Synthesis Published In Journal of Natural Products Volume 82 Pages 358 - 367 ISSN 0163-3864 Altmetric
2019	Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum Published In Journal of Natural Products Volume 82 Pages 3176 - 3180 ISSN 0163-3864 Altmetric
2019	Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones Published In Chemical Science Volume 10 Pages 9051 - 9056 ISSN 2041-6520 Altmetric
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published In Angewandte Chemie International Edition Volume 58 Pages 2114 - 2119 ISSN 1433-7851 Altmetric
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published In Chemical Communications Volume 55 Pages 6050 - 6053 ISSN 1359-7345 Altmetric
2019	Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis Published In Journal of Natural Products Volume 82 Pages 2174 - 2180 ISSN 0163-3864 Altmetric
2019	Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities Published In Journal of Natural Products Altmetric
2019	Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis Published In Journal of Natural Products Volume 82 Pages 101 - 110 ISSN 0163-3864 Altmetric
2019	Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus Published In Natural Product Communications: an international journal for communications and reviews Volume 14 Pages 1 - 5 ISSN 1555-9475 Altmetric
2019	Progress toward the total synthesis of 9β-hydroxyvertine: Construction of an advanced quinolizidine intermediate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 75 Pages 130476-1 - 130476-24 ISSN 0040-4020 Altmetric
2019	Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae) Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 75 Pages 2336 - 2342 ISSN 0040-4039 Altmetric
2019	The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis Published In Current Organic Synthesis Volume 16 Pages 498 - 522 Altmetric
2019	Utilization of electrocoagulation for the isolation of alkaloids from the aerial parts of Stemona aphylla and their mosquitocidal activities against Aedes aegypti Published In Ecotoxicology and Environmental Safety Volume 182 Pages 109448-1 - 109448-8 ISSN 0147-6513 Altmetric
2019	Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leaf extracts of Uvaria lurida Published In Fitoterapia Volume 138 Pages 104340 - 104340 ISSN 1971-551X Altmetric
2019	α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis Published In Journal of Natural Products Volume 82 Pages 741 - 747 ISSN 0163-3864 Altmetric
2018	12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea Published In Natural Product Communications: an international journal for communications and reviews Volume 13 Pages 1327 - 1328 ISSN 1555-9475
2018	A pharmacological strategy using stemofoline for more efficacious chemotherapeutic treatments against human multidrug resistant leukemic cells Published In Asian Pacific Journal of Cancer Prevention (APJCP) Volume 19 Pages 3533 - 3543 ISSN 1513-7368 Altmetric
2018	Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii Published In Phytochemistry Letters Volume 23 Pages 33 - 37 ISSN 1874-3900 Altmetric
2018	Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa Published In Journal of Natural Products Volume 81 Pages 1835 - 1840 ISSN 0163-3864 Altmetric
2018	Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1478-6419 Altmetric
2018	Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU Published In Fitoterapia Volume 130 Pages 219 - 224 Altmetric
2018	Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum Published In Natural Product Research Volume Online First Pages 1 - 6 ISSN 1478-6419 Altmetric
2018	Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis Published In Fitoterapia Volume 130 Pages 198 - 202 Altmetric
2018	Gold- and Silver-Catalysed Cyclisation Reactions of β-Amino Allenes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 71 Pages 682 - 689 ISSN 0004-9425 Altmetric
2018	Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1478-6419 Altmetric
2018	Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells Published In Fitoterapia Volume 124 Pages 34 - 41 Altmetric
2018	Total Synthesis of Natural Hyacinthacine C5, and six Related Hyacinthacine C5 Epimers Published In Journal of Organic Chemistry Volume 83 Pages 5558 - 5576 ISSN 0022-3263 Altmetric
2017	2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae) Published In Fitoterapia Volume 120 Pages 103 - 107 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 0040-4020 Altmetric
2017	Allenylation and propargylation reactions of ketones, aldehydes, imines, and iminium ions using organoboronates and related derivatives Published In Synthesis: journal of synthetic organic chemistry Volume 49 Pages 1461 - 1480 ISSN 0039-7881 Altmetric
2017	Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1478-6419 Altmetric
2017	Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1073 - 1076 ISSN 1555-9475
2017	Hybrid flavan–flavanones from Friesodielsia desmoides and their inhibitory activities against nitric oxide production Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 17545 - 17550 ISSN 2046-2069 Altmetric
2017	Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships Published In Phytomedicine Volume 34 Pages 182 - 190 ISSN 1618-095X Altmetric
2017	Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of L-α-Amino Aldehydes Published In Journal of Organic Chemistry Volume 82 Pages 6819 - 6830 ISSN 0022-3263 Altmetric
2017	Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytotoxic activities of Graptophyllum pictum (L.) Griff Published In Chiang Mai Journal of Science Volume 44 Pages 193 - 202 ISSN 0125-2526
2017	Phytochemical, Synthetic and Biological Studies on Stemona and Stichoneuron Plants and Alkaloids: A Personal Perspective Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1365 - 1369 ISSN 1555-9475
2017	Scalemic caged xanthones isolated from the stem bark extract of Garcinia propinqua Published In Journal of Natural Products Volume 80 Pages 1658 - 1667 ISSN 0163-3864 Altmetric
2017	Two phenylethanoid glycosides, Parvifloroside A and B, isolated from Barleria strigosa Published In Chiang Mai Journal of Science Volume 44 Pages 168 - 175 ISSN 0125-2526
2016	A concise synthesis of furo[3,2-c]coumarins catalyzed by nanocrystalline ZnZr4(PO4)6 ceramics under microwave irradiation Published In Journal of the Iranian Chemical Society Volume 13 Pages 1439 - 1448 ISSN 1735-207X Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata Published In Journal of Natural Products Volume 79 Pages 978 - 983 ISSN 0163-3864 Altmetric
2016	Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 72 Pages 6837 - 6842 ISSN 0040-4020 Altmetric
2016	Determination of antioxidant and anticancer activities together with total phenol and flavonoid contents of Cleidion javanicum Bl. And Bridelia retusa (L.) A. Juss Published In Chiang Mai Journal of Science Volume 43 Pages 534 - 545 ISSN 0125-2526
2016	Effects of chitosan and salicylic acid on stemona alkaloid production in hydroponic culture of stemona curtisii Hook. f. Published In Chiang Mai Journal of Science Volume 43 Pages 1070 - 1076 ISSN 0125-2526
2016	Essential oil of solanum spirale fruits and its biological activities Published In Chiang Mai Journal of Science Volume 43 Pages 546 - 554 ISSN 0125-2526
2016	Synthesis of bridged heterocycles via sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: mechanistic and computational studies Published In Journal of Organic Chemistry Volume 81 Pages 1434 - 1449 ISSN 0022-3263 Altmetric
2016	Synthesis of furo[3,2-c]coumarins under microwave irradiation using nano-CoFe₂O₄@SiO₂–PrNH₂ as an efficient and magnetically reusable catalyst Published In Khimiya Geterotsiklicheskikh Soedinenii Volume 52 Pages 288 - 293 ISSN 0009-3122 Altmetric
2016	Synthesis of α-propargylglycinates using the borono-mannich reaction with pinacol allenylboronate and potassium allenyltrifluoroborate Published In European Journal of Organic Chemistry Volume 2016 Pages 3765 - 3772 ISSN 1099-0690 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2016	The isolation of lutein and lutein 3'-methyl ether from peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1793 - 1795 ISSN 1555-9475
2016	Two new bioactive iridoids from Rothmannia wittii Published In Fitoterapia Volume 113 Pages 97 - 101 ISSN 1971-551X Altmetric
2015	Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities Published In Phytochemistry Letters Volume 11 Pages 157 - 162 Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum Published In Natural Product Communications: an international journal for communications and reviews Volume 10 Pages 1175 - 1177 ISSN 1555-9475
2015	Diastereoselective synthesis of the A-B-C tricyclic ring structure of stemocurtisine Published In European Journal of Organic Chemistry Volume 2015 Pages 7682 - 7694 ISSN 1099-0690 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Regioselective and diastereoselective borono-mannich reactions with pinacol allenylboronate Published In Organic Letters Volume 17 Pages 778 - 781 ISSN 1523-7060 Altmetric
2015	Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of p-glycoprotein function Published In Basic and Clinical Pharmacology and Toxicology Volume 116 Pages 390 - 397 ISSN 1742-7835 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2015	The chemical constituents and biological activities of the essential oil and the extracts from leaves of Gynura divaricata (L.) DC. growing in Thailand Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 543 - 555 Altmetric
2015	The chemical constituents and the cytotoxicity, antioxidant and antibacterial activities of the essential oil of Graptophyllum pictum (L.) Griff Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 11 - 17 Altmetric
2014	A new 1,6-benzoxazocine-5-one alkaloid isolated from the aerial parts of Peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 1433 - 1435 ISSN 1555-9475
2014	Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities Published In Journal of Natural Products Volume 77 Pages 894 - 901 ISSN 0163-3864 Altmetric
2014	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa Published In Fitoterapia Volume 98 Pages 179 - 183 ISSN 1971-551X Altmetric
2014	Carbazole alkaloids and coumarins from the roots of Clausena guillauminii Published In Phytochemistry Letters Volume 9 Pages 113 - 116 ISSN 1874-3900 Altmetric
2014	Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 475 - 478 ISSN 0040-4039 Altmetric
2014	Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling Published In Journal of Chemical and Pharmaceutical Research Volume 6 Pages 544 - 548
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	The boronic acid Mannich reaction Published In Organic Reactions Volume 83 Pages 211 - 498 Altmetric
2014	Total synthesis of hyacinthacines B3, B4, and B 5 and purported hyacinthacine B7, 7-epi-hyacinthacine B7, and 7a-epi-hyacinthacine B3 from a common precursor Published In Journal of Organic Chemistry Volume 79 Pages 4569 - 4581 ISSN 0022-3263 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric

Investigator On

Year	Title
2020	Discovering novel drug lead compounds for inflammatory bowel disease from Australian Aboriginal tropical medicinal plants Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2018 - 2020	A New Molecular Platform for Catalytic Synthesis of Heterocycles Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	New strategies for the stereoselective synthesis of stemona alkaloids and the Discovery of new bioactive molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Sensitive and multinuclear: dedicated facility for high-throughput characterization of small molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Stereoselective synthesis of bioactive alkaloids for structure elucidation and drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Large scale production of stemona alkaloids for agricultural applications and new drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	Gold-catalysed reactions for the synthesis of medicinally important molecules.	Thadkapally, Srinivas
Doctor of Philosophy	Developing Selective Arsenic Anti-Cancer Drugs	Lambert, Jacob
Doctor of Philosophy	Enhanced Scope of the Borono-Mannich Reactions with Methylallenyl Boronate and Organometallic Catalysed Cyclisations	Joyce, Liam
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Investigation into the Stereochemistry of Metal-Catalysed Reactions for the Synthesis of Medicinally Relevant Molecules.	Bird, Melissa
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Development of chemical reactions for the synthesis of bioactive heterocycles	Pham, Pham
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	Development of a Catalytic Asymmetric Fluoro-Petasis Reaction to the Synthesis of Bioactive Fluorinated Heterocycles	Chevis, Philip
Doctor of Philosophy	Allenox - a novel molecular building block for chemical synthesis	Chao, Chi Bong Eric
Master of Philosophy -SMAH	Method development towards the synthesis of the alkaloid Alexine using 3-alkoxy, 3-acyloxy or 3-trialkylsilyl allyl organo indium, zinc or boron reagents	Alyamani, Asma

Orcid Id

http://orcid.org/0000-0003-0462-0277 (confirmed)

Scopus Id

35496446700

Top Publications

Year	Title
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published in European Journal of Medicinal Chemistry
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published in Angewandte Chemie International Edition
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published in Chemical Communications

Research Areas

Research Overview

The Pyne research group comprises seven PhD students and two Research Associates, some of which are jointly supervised by Prof. Paul Keller and Dr. Chris Hyland. We are working on projects in the following areas:

Discovery of new chemical reactions. Oranoboron reagents and organometallic catalysts are beeing developed for the synthesis of bioactive natural products, drug-like molecules and novel chemical scaffolds for drug discovery (ARC funded with Dr. Chris Hyland). Research Fellow: Dr. Melanie Drew; PhD students: Brendan Bryant, Philip Chevis, Liam Joyce, Srinivas Thadkapally and Quoc Pham.

Discovery and development of new antibacterial agents against pathogenic bacteria (especially Clostridium difficile and Acinetobacter baumannii) (NHMRC funded with Prof. Paul Keller and Assoc. Prof. Haibo Yu). Research Fellow: Dr. Andrew Tague; PhD students: Wendy Cun and Muni Mahadari

Natural products chemistry on traditional medicinal plants from Nigeria and SE Asia. PhD students: Christiana Dawurung, Thanika Promchai and Isaraporn Polbuppha

Selected Publications

Journal Article

Year	Title
2020	A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae) Published In Natural Product Research Altmetric
2020	Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f. Published In Natural Product Research Altmetric
2020	Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis Published In Organic and Biomolecular Chemistry Volume Online First Pages 1 - 19 ISSN 1477-0520 Altmetric
2020	Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea Published In Phytochemistry Volume 179 Altmetric
2020	Styryllactones from Goniothalamus tamirensis Published In Phytochemistry Volume 171 Altmetric
2020	α-Glucosidase Inhibitory Activity of the Extracts and Major Phytochemical Components of Smilax glabra Roxb Published In Natural Products Journal Volume 10 Pages 26 - 32 Altmetric
2020	α-Glucosidase inhibitory and nitric oxide production inhibitory activities of alkaloids isolated from a twig extract of Polyalthia cinnamomea Published In Bioorganic and Medicinal Chemistry Altmetric
2019	(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities Published In Natural Product Research Altmetric
2019	1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N -acyliminium ions: Synthetic and computational studies Published In Organic and Biomolecular Chemistry Volume 17 Pages 7025 - 7035 ISSN 1477-0520 Altmetric
2019	A new xanthone and a biphenyl from the flower and twig extracts of Garcinia mckeaniana Published In Natural Product Research Altmetric
2019	A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata Published In Fitoterapia Volume 136 Pages 104175-1 - 104175-6 Altmetric
2019	Alkaloids and styryllactones from Goniothalamus cheliensis Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 157 Pages 8 - 20 ISSN 0031-9422 Altmetric
2019	Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis Published In Journal of Natural Products Volume 82 Pages 283 - 292 ISSN 0163-3864 Altmetric
2019	Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa Published In Journal of Natural Products Volume 82 Pages 2343 - 2348 ISSN 0163-3864 Altmetric
2019	Antidiarrheal activity of some selected Nigerian plants used in traditional medicine Published In Pharmacognosy Research Volume 11 Pages 371 - 377 ISSN 0974-8490 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species Published In Natural Product Research Volume 33 Pages 553 - 556 ISSN 1478-6419 Altmetric
2019	Corrected Structure of Natural Hyacinthacine C 1 via Total Synthesis Published In Journal of Natural Products Volume 82 Pages 358 - 367 ISSN 0163-3864 Altmetric
2019	Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum Published In Journal of Natural Products Volume 82 Pages 3176 - 3180 ISSN 0163-3864 Altmetric
2019	Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones Published In Chemical Science Volume 10 Pages 9051 - 9056 ISSN 2041-6520 Altmetric
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published In Angewandte Chemie International Edition Volume 58 Pages 2114 - 2119 ISSN 1433-7851 Altmetric
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published In Chemical Communications Volume 55 Pages 6050 - 6053 ISSN 1359-7345 Altmetric
2019	Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis Published In Journal of Natural Products Volume 82 Pages 2174 - 2180 ISSN 0163-3864 Altmetric
2019	Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities Published In Journal of Natural Products Altmetric
2019	Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis Published In Journal of Natural Products Volume 82 Pages 101 - 110 ISSN 0163-3864 Altmetric
2019	Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus Published In Natural Product Communications: an international journal for communications and reviews Volume 14 Pages 1 - 5 ISSN 1555-9475 Altmetric
2019	Progress toward the total synthesis of 9β-hydroxyvertine: Construction of an advanced quinolizidine intermediate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 75 Pages 130476-1 - 130476-24 ISSN 0040-4020 Altmetric
2019	Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae) Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 75 Pages 2336 - 2342 ISSN 0040-4039 Altmetric
2019	The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis Published In Current Organic Synthesis Volume 16 Pages 498 - 522 Altmetric
2019	Utilization of electrocoagulation for the isolation of alkaloids from the aerial parts of Stemona aphylla and their mosquitocidal activities against Aedes aegypti Published In Ecotoxicology and Environmental Safety Volume 182 Pages 109448-1 - 109448-8 ISSN 0147-6513 Altmetric
2019	Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leaf extracts of Uvaria lurida Published In Fitoterapia Volume 138 Pages 104340 - 104340 ISSN 1971-551X Altmetric
2019	α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis Published In Journal of Natural Products Volume 82 Pages 741 - 747 ISSN 0163-3864 Altmetric
2018	12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea Published In Natural Product Communications: an international journal for communications and reviews Volume 13 Pages 1327 - 1328 ISSN 1555-9475
2018	A pharmacological strategy using stemofoline for more efficacious chemotherapeutic treatments against human multidrug resistant leukemic cells Published In Asian Pacific Journal of Cancer Prevention (APJCP) Volume 19 Pages 3533 - 3543 ISSN 1513-7368 Altmetric
2018	Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii Published In Phytochemistry Letters Volume 23 Pages 33 - 37 ISSN 1874-3900 Altmetric
2018	Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa Published In Journal of Natural Products Volume 81 Pages 1835 - 1840 ISSN 0163-3864 Altmetric
2018	Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1478-6419 Altmetric
2018	Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU Published In Fitoterapia Volume 130 Pages 219 - 224 Altmetric
2018	Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum Published In Natural Product Research Volume Online First Pages 1 - 6 ISSN 1478-6419 Altmetric
2018	Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis Published In Fitoterapia Volume 130 Pages 198 - 202 Altmetric
2018	Gold- and Silver-Catalysed Cyclisation Reactions of β-Amino Allenes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 71 Pages 682 - 689 ISSN 0004-9425 Altmetric
2018	Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1478-6419 Altmetric
2018	Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells Published In Fitoterapia Volume 124 Pages 34 - 41 Altmetric
2018	Total Synthesis of Natural Hyacinthacine C5, and six Related Hyacinthacine C5 Epimers Published In Journal of Organic Chemistry Volume 83 Pages 5558 - 5576 ISSN 0022-3263 Altmetric
2017	2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae) Published In Fitoterapia Volume 120 Pages 103 - 107 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 0040-4020 Altmetric
2017	Allenylation and propargylation reactions of ketones, aldehydes, imines, and iminium ions using organoboronates and related derivatives Published In Synthesis: journal of synthetic organic chemistry Volume 49 Pages 1461 - 1480 ISSN 0039-7881 Altmetric
2017	Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1478-6419 Altmetric
2017	Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1073 - 1076 ISSN 1555-9475
2017	Hybrid flavan–flavanones from Friesodielsia desmoides and their inhibitory activities against nitric oxide production Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 17545 - 17550 ISSN 2046-2069 Altmetric
2017	Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships Published In Phytomedicine Volume 34 Pages 182 - 190 ISSN 1618-095X Altmetric
2017	Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of L-α-Amino Aldehydes Published In Journal of Organic Chemistry Volume 82 Pages 6819 - 6830 ISSN 0022-3263 Altmetric
2017	Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytotoxic activities of Graptophyllum pictum (L.) Griff Published In Chiang Mai Journal of Science Volume 44 Pages 193 - 202 ISSN 0125-2526
2017	Phytochemical, Synthetic and Biological Studies on Stemona and Stichoneuron Plants and Alkaloids: A Personal Perspective Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1365 - 1369 ISSN 1555-9475
2017	Scalemic caged xanthones isolated from the stem bark extract of Garcinia propinqua Published In Journal of Natural Products Volume 80 Pages 1658 - 1667 ISSN 0163-3864 Altmetric
2017	Two phenylethanoid glycosides, Parvifloroside A and B, isolated from Barleria strigosa Published In Chiang Mai Journal of Science Volume 44 Pages 168 - 175 ISSN 0125-2526
2016	A concise synthesis of furo[3,2-c]coumarins catalyzed by nanocrystalline ZnZr4(PO4)6 ceramics under microwave irradiation Published In Journal of the Iranian Chemical Society Volume 13 Pages 1439 - 1448 ISSN 1735-207X Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata Published In Journal of Natural Products Volume 79 Pages 978 - 983 ISSN 0163-3864 Altmetric
2016	Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 72 Pages 6837 - 6842 ISSN 0040-4020 Altmetric
2016	Determination of antioxidant and anticancer activities together with total phenol and flavonoid contents of Cleidion javanicum Bl. And Bridelia retusa (L.) A. Juss Published In Chiang Mai Journal of Science Volume 43 Pages 534 - 545 ISSN 0125-2526
2016	Effects of chitosan and salicylic acid on stemona alkaloid production in hydroponic culture of stemona curtisii Hook. f. Published In Chiang Mai Journal of Science Volume 43 Pages 1070 - 1076 ISSN 0125-2526
2016	Essential oil of solanum spirale fruits and its biological activities Published In Chiang Mai Journal of Science Volume 43 Pages 546 - 554 ISSN 0125-2526
2016	Synthesis of bridged heterocycles via sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: mechanistic and computational studies Published In Journal of Organic Chemistry Volume 81 Pages 1434 - 1449 ISSN 0022-3263 Altmetric
2016	Synthesis of furo[3,2-c]coumarins under microwave irradiation using nano-CoFe₂O₄@SiO₂–PrNH₂ as an efficient and magnetically reusable catalyst Published In Khimiya Geterotsiklicheskikh Soedinenii Volume 52 Pages 288 - 293 ISSN 0009-3122 Altmetric
2016	Synthesis of α-propargylglycinates using the borono-mannich reaction with pinacol allenylboronate and potassium allenyltrifluoroborate Published In European Journal of Organic Chemistry Volume 2016 Pages 3765 - 3772 ISSN 1099-0690 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2016	The isolation of lutein and lutein 3'-methyl ether from peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1793 - 1795 ISSN 1555-9475
2016	Two new bioactive iridoids from Rothmannia wittii Published In Fitoterapia Volume 113 Pages 97 - 101 ISSN 1971-551X Altmetric
2015	Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities Published In Phytochemistry Letters Volume 11 Pages 157 - 162 Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum Published In Natural Product Communications: an international journal for communications and reviews Volume 10 Pages 1175 - 1177 ISSN 1555-9475
2015	Diastereoselective synthesis of the A-B-C tricyclic ring structure of stemocurtisine Published In European Journal of Organic Chemistry Volume 2015 Pages 7682 - 7694 ISSN 1099-0690 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Regioselective and diastereoselective borono-mannich reactions with pinacol allenylboronate Published In Organic Letters Volume 17 Pages 778 - 781 ISSN 1523-7060 Altmetric
2015	Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of p-glycoprotein function Published In Basic and Clinical Pharmacology and Toxicology Volume 116 Pages 390 - 397 ISSN 1742-7835 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2015	The chemical constituents and biological activities of the essential oil and the extracts from leaves of Gynura divaricata (L.) DC. growing in Thailand Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 543 - 555 Altmetric
2015	The chemical constituents and the cytotoxicity, antioxidant and antibacterial activities of the essential oil of Graptophyllum pictum (L.) Griff Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 11 - 17 Altmetric
2014	A new 1,6-benzoxazocine-5-one alkaloid isolated from the aerial parts of Peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 1433 - 1435 ISSN 1555-9475
2014	Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities Published In Journal of Natural Products Volume 77 Pages 894 - 901 ISSN 0163-3864 Altmetric
2014	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa Published In Fitoterapia Volume 98 Pages 179 - 183 ISSN 1971-551X Altmetric
2014	Carbazole alkaloids and coumarins from the roots of Clausena guillauminii Published In Phytochemistry Letters Volume 9 Pages 113 - 116 ISSN 1874-3900 Altmetric
2014	Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 475 - 478 ISSN 0040-4039 Altmetric
2014	Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling Published In Journal of Chemical and Pharmaceutical Research Volume 6 Pages 544 - 548
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	The boronic acid Mannich reaction Published In Organic Reactions Volume 83 Pages 211 - 498 Altmetric
2014	Total synthesis of hyacinthacines B3, B4, and B 5 and purported hyacinthacine B7, 7-epi-hyacinthacine B7, and 7a-epi-hyacinthacine B3 from a common precursor Published In Journal of Organic Chemistry Volume 79 Pages 4569 - 4581 ISSN 0022-3263 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric

Investigator On

Year	Title
2020	Discovering novel drug lead compounds for inflammatory bowel disease from Australian Aboriginal tropical medicinal plants Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2018 - 2020	A New Molecular Platform for Catalytic Synthesis of Heterocycles Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	New strategies for the stereoselective synthesis of stemona alkaloids and the Discovery of new bioactive molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Sensitive and multinuclear: dedicated facility for high-throughput characterization of small molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Stereoselective synthesis of bioactive alkaloids for structure elucidation and drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Large scale production of stemona alkaloids for agricultural applications and new drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	Gold-catalysed reactions for the synthesis of medicinally important molecules.	Thadkapally, Srinivas
Doctor of Philosophy	Developing Selective Arsenic Anti-Cancer Drugs	Lambert, Jacob
Doctor of Philosophy	Enhanced Scope of the Borono-Mannich Reactions with Methylallenyl Boronate and Organometallic Catalysed Cyclisations	Joyce, Liam
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Investigation into the Stereochemistry of Metal-Catalysed Reactions for the Synthesis of Medicinally Relevant Molecules.	Bird, Melissa
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Development of chemical reactions for the synthesis of bioactive heterocycles	Pham, Pham
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	Development of a Catalytic Asymmetric Fluoro-Petasis Reaction to the Synthesis of Bioactive Fluorinated Heterocycles	Chevis, Philip
Doctor of Philosophy	Allenox - a novel molecular building block for chemical synthesis	Chao, Chi Bong Eric
Master of Philosophy -SMAH	Method development towards the synthesis of the alkaloid Alexine using 3-alkoxy, 3-acyloxy or 3-trialkylsilyl allyl organo indium, zinc or boron reagents	Alyamani, Asma

Orcid Id

http://orcid.org/0000-0003-0462-0277 (confirmed)

Scopus Id

35496446700

Pyne, Stephen G. Senior Professor

Professor of Chemistry

Overview

Overview

Top Publications

Research Areas

Research Overview

Publications

Selected Publications

Journal Article

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Overview

Top Publications

Research Areas

Research Overview

Publications

Selected Publications

Journal Article

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas