Pyne, Stephen G.

Overview

Prof. Stephen Pyne received his BSc (Hons) at Adelaide University (top first class) and his PhD in 1979 from the Australian National University. After postdoctoral research fellowships at Purdue University (with P. Fuchs) and Harvard (with E.J. Corey) he was appointed as a lecturer at the University of Wollongong in 1985. In 1998 he was appointed to Professor. He won the A.J. Birch Medal for excellence in Organic Chemistry Research, from the Organic Division of the Royal Australian Chemical Institute in 2012 and the Archibald Ollé Prize for Chemical Literature in 2015. He has published more than 330 journal publications (h-index 42) in the areas of new methods for the asymmetric synthesis of bioactive molecules; the total synthesis of bioactive natural products, especially alkaloids; the development of novel antibacterial agents against pathological bacteria; and natural products chemistry.

Top Publications

Year	Title
2018	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published in European Journal of Medicinal Chemistry
2018	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published in Angewandte Chemie International Edition
2018	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published in Chemical Communications

Research Areas

Research Overview

The Pyne research group comprises seven PhD students and two Research Associates, some of which are jointly supervised by Prof. Paul Keller and Dr. Chris Hyland. We are working on projects in the following areas:

Discovery of new chemical reactions. Oranoboron reagents and organometallic catalysts are beeing developed for the synthesis of bioactive natural products, drug-like molecules and novel chemical scaffolds for drug discovery (ARC funded with Dr. Chris Hyland). Research Fellow: Dr. Melanie Drew; PhD students: Brendan Bryant, Philip Chevis, Liam Joyce, Srinivas Thadkapally and Quoc Pham.

Discovery and development of new antibacterial agents against pathogenic bacteria (especially Clostridium difficile and Acinetobacter baumannii) (NHMRC funded with Prof. Paul Keller and Assoc. Prof. Haibo Yu). Research Fellow: Dr. Andrew Tague; PhD students: Wendy Cun and Muni Mahadari

Natural products chemistry on traditional medicinal plants from Nigeria and SE Asia. PhD students: Christiana Dawurung, Thanika Promchai and Isaraporn Polbuppha

Selected Publications

Journal Article

Year	Title
2019	1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N -acyliminium ions: Synthetic and computational studies Published In Organic and Biomolecular Chemistry Volume 17 Pages 7025 - 7035 ISSN 1477-0520 Altmetric
2019	A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata Published In Fitoterapia Volume 136 Pages 104175-1 - 104175-6 Altmetric
2019	Alkaloids and styryllactones from Goniothalamus cheliensis Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 157 Pages 8 - 20 ISSN 0031-9422 Altmetric
2019	Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis Published In Journal of Natural Products Volume 82 Pages 283 - 292 ISSN 0163-3864 Altmetric
2019	Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa Published In Journal of Natural Products Volume 82 Pages 2343 - 2348 ISSN 0163-3864 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species Published In Natural Product Research Volume 33 Pages 553 - 556 ISSN 1026-8049 Altmetric
2019	Corrected Structure of Natural Hyacinthacine C 1 via Total Synthesis Published In Journal of Natural Products Volume 82 Pages 358 - 367 ISSN 0163-3864 Altmetric
2019	Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones Published In Chemical Science Volume 10 Pages 9051 - 9056 ISSN 2041-6520 Altmetric
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published In Angewandte Chemie International Edition Volume 58 Pages 2114 - 2119 ISSN 1433-7851 Altmetric
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published In Chemical Communications Volume 55 Pages 6050 - 6053 ISSN 1364-548X Altmetric
2019	Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis Published In Journal of Natural Products Volume 82 Pages 2174 - 2180 ISSN 0163-3864 Altmetric
2019	Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis Published In Journal of Natural Products Volume 82 Pages 101 - 110 ISSN 0163-3864 Altmetric
2019	Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus Published In Natural Product Communications: an international journal for communications and reviews Volume Online First Pages 1 - 5 ISSN 1555-9475 Altmetric
2019	Progress toward the total synthesis of 9β-hydroxyvertine: Construction of an advanced quinolizidine intermediate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 75 Pages 130476-1 - 130476-24 ISSN 1464-5416 Altmetric
2019	Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae) Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 75 Pages 2336 - 2342 ISSN 0040-4039 Altmetric
2019	The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis Published In Current Organic Synthesis Volume 16 Pages 498 - 522 Altmetric
2019	Utilization of electrocoagulation for the isolation of alkaloids from the aerial parts of Stemona aphylla and their mosquitocidal activities against Aedes aegypti Published In Ecotoxicology and Environmental Safety Volume 182 Pages 109448-1 - 109448-8 ISSN 0147-6513 Altmetric
2019	Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leaf extracts of Uvaria lurida Published In Fitoterapia Volume 138 Pages 104340 - 104340 ISSN 1971-551X Altmetric
2019	α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis Published In Journal of Natural Products Volume 82 Pages 741 - 747 ISSN 0163-3864 Altmetric
2018	12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea Published In Natural Product Communications: an international journal for communications and reviews Volume 13 Pages 1327 - 1328 ISSN 1555-9475
2018	A pharmacological strategy using stemofoline for more efficacious chemotherapeutic treatments against human multidrug resistant leukemic cells Published In Asian Pacific Journal of Cancer Prevention (APJCP) Volume 19 Pages 3533 - 3543 ISSN 1513-7368 Altmetric
2018	Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii Published In Phytochemistry Letters Volume 23 Pages 33 - 37 ISSN 1874-3900 Altmetric
2018	Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa Published In Journal of Natural Products Volume 81 Pages 1835 - 1840 ISSN 0163-3864 Altmetric
2018	Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1026-8049 Altmetric
2018	Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU Published In Fitoterapia Volume 130 Pages 219 - 224 Altmetric
2018	Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum Published In Natural Product Research Volume Online First Pages 1 - 6 ISSN 1026-8049 Altmetric
2018	Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis Published In Fitoterapia Volume 130 Pages 198 - 202 Altmetric
2018	Gold- and Silver-Catalysed Cyclisation Reactions of β-Amino Allenes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 71 Pages 682 - 689 ISSN 0004-9425 Altmetric
2018	Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1026-8049 Altmetric
2018	Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells Published In Fitoterapia Volume 124 Pages 34 - 41 Altmetric
2018	Total Synthesis of Natural Hyacinthacine C5, and six Related Hyacinthacine C5 Epimers Published In Journal of Organic Chemistry Volume 83 Pages 5558 - 5576 ISSN 0022-3263 Altmetric
2017	2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae) Published In Fitoterapia Volume 120 Pages 103 - 107 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Allenylation and propargylation reactions of ketones, aldehydes, imines, and iminium ions using organoboronates and related derivatives Published In Synthesis: journal of synthetic organic chemistry Volume 49 Pages 1461 - 1480 ISSN 0039-7881 Altmetric
2017	Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1026-8049 Altmetric
2017	Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1073 - 1076 ISSN 1555-9475
2017	Hybrid flavan–flavanones from Friesodielsia desmoides and their inhibitory activities against nitric oxide production Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 17545 - 17550 ISSN 2046-2069 Altmetric
2017	Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships Published In Phytomedicine Volume 34 Pages 182 - 190 ISSN 1618-095X Altmetric
2017	Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of L-α-Amino Aldehydes Published In Journal of Organic Chemistry Volume 82 Pages 6819 - 6830 ISSN 0022-3263 Altmetric
2017	Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytotoxic activities of Graptophyllum pictum (L.) Griff Published In Chiang Mai Journal of Science Volume 44 Pages 193 - 202 ISSN 0125-2526
2017	Phytochemical, Synthetic and Biological Studies on Stemona and Stichoneuron Plants and Alkaloids: A Personal Perspective Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1365 - 1369 ISSN 1555-9475
2017	Scalemic caged xanthones isolated from the stem bark extract of Garcinia propinqua Published In Journal of Natural Products Volume 80 Pages 1658 - 1667 ISSN 0163-3864 Altmetric
2017	Two phenylethanoid glycosides, Parvifloroside A and B, isolated from Barleria strigosa Published In Chiang Mai Journal of Science Volume 44 Pages 168 - 175 ISSN 0125-2526
2016	A concise synthesis of furo[3,2-c]coumarins catalyzed by nanocrystalline ZnZr4(PO4)6 ceramics under microwave irradiation Published In Journal of the Iranian Chemical Society Volume 13 Pages 1439 - 1448 ISSN 1735-207X Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata Published In Journal of Natural Products Volume 79 Pages 978 - 983 ISSN 0163-3864 Altmetric
2016	Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 72 Pages 6837 - 6842 ISSN 1464-5416 Altmetric
2016	Determination of antioxidant and anticancer activities together with total phenol and flavonoid contents of Cleidion javanicum Bl. And Bridelia retusa (L.) A. Juss Published In Chiang Mai Journal of Science Volume 43 Pages 534 - 545 ISSN 0125-2526
2016	Effects of chitosan and salicylic acid on stemona alkaloid production in hydroponic culture of stemona curtisii Hook. f. Published In Chiang Mai Journal of Science Volume 43 Pages 1070 - 1076 ISSN 0125-2526
2016	Essential oil of solanum spirale fruits and its biological activities Published In Chiang Mai Journal of Science Volume 43 Pages 546 - 554 ISSN 0125-2526
2016	Synthesis of bridged heterocycles via sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: mechanistic and computational studies Published In Journal of Organic Chemistry Volume 81 Pages 1434 - 1449 ISSN 0022-3263 Altmetric
2016	Synthesis of furo[3,2-c]coumarins under microwave irradiation using nano-CoFe₂O₄@SiO₂–PrNH₂ as an efficient and magnetically reusable catalyst Published In Khimiya Geterotsiklicheskikh Soedinenii Volume 52 Pages 288 - 293 ISSN 0009-3122 Altmetric
2016	Synthesis of α-propargylglycinates using the borono-mannich reaction with pinacol allenylboronate and potassium allenyltrifluoroborate Published In European Journal of Organic Chemistry Volume 2016 Pages 3765 - 3772 ISSN 1099-0690 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2016	The isolation of lutein and lutein 3'-methyl ether from peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1793 - 1795 ISSN 1555-9475
2016	Two new bioactive iridoids from Rothmannia wittii Published In Fitoterapia Volume 113 Pages 97 - 101 ISSN 1971-551X Altmetric
2015	Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities Published In Phytochemistry Letters Volume 11 Pages 157 - 162 Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum Published In Natural Product Communications: an international journal for communications and reviews Volume 10 Pages 1175 - 1177 ISSN 1555-9475
2015	Diastereoselective synthesis of the A-B-C tricyclic ring structure of stemocurtisine Published In European Journal of Organic Chemistry Volume 2015 Pages 7682 - 7694 ISSN 1099-0690 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Regioselective and diastereoselective borono-mannich reactions with pinacol allenylboronate Published In Organic Letters Volume 17 Pages 778 - 781 ISSN 1523-7060 Altmetric
2015	Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of p-glycoprotein function Published In Basic and Clinical Pharmacology and Toxicology Volume 116 Pages 390 - 397 ISSN 1742-7835 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2015	The chemical constituents and biological activities of the essential oil and the extracts from leaves of Gynura divaricata (L.) DC. growing in Thailand Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 543 - 555 Altmetric
2015	The chemical constituents and the cytotoxicity, antioxidant and antibacterial activities of the essential oil of Graptophyllum pictum (L.) Griff Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 11 - 17 Altmetric
2014	A new 1,6-benzoxazocine-5-one alkaloid isolated from the aerial parts of Peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 1433 - 1435 ISSN 1555-9475
2014	Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities Published In Journal of Natural Products Volume 77 Pages 894 - 901 ISSN 0163-3864 Altmetric
2014	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa Published In Fitoterapia Volume 98 Pages 179 - 183 ISSN 1971-551X Altmetric
2014	Carbazole alkaloids and coumarins from the roots of Clausena guillauminii Published In Phytochemistry Letters Volume 9 Pages 113 - 116 ISSN 1874-3900 Altmetric
2014	Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 475 - 478 ISSN 0040-4039 Altmetric
2014	Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling Published In Journal of Chemical and Pharmaceutical Research Volume 6 Pages 544 - 548
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	The boronic acid Mannich reaction Published In Organic Reactions Volume 83 Pages 211 - 498 Altmetric
2014	Total synthesis of hyacinthacines B3, B4, and B 5 and purported hyacinthacine B7, 7-epi-hyacinthacine B7, and 7a-epi-hyacinthacine B3 from a common precursor Published In Journal of Organic Chemistry Volume 79 Pages 4569 - 4581 ISSN 0022-3263 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric
2013	6-Hydroxy-5,6-seco-stemocurtisine: a novel seco-stemocurtisine-type alkaloid Published In Phytochemistry Letters Volume 6 Pages 602 - 605 ISSN 1874-3900 Altmetric
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology Volume 150 Pages 953 - 959 ISSN 0378-8741 Altmetric
2013	Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 695 - 698 ISSN 1555-9475
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology Volume 148 Pages 305 - 310 ISSN 0378-8741 Altmetric
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 733 - 736 ISSN 1555-9475
2013	Bioactive compounds from the roots of Strophioblachia fimbricalyx Published In Journal of Natural Products Volume 76 Pages 1358 - 1364 ISSN 0163-3864 Altmetric
2013	Chemical constituents and biological activities of Garcinia cowa Roxb Published In Maejo International Journal of Science and Technology Volume 7 Pages 212 - 231
2013	Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities Published In Organic and Biomolecular Chemistry Volume 11 Pages 3826 - 3833 ISSN 1477-0520 Altmetric
2013	Concise synthesis of α-substituted 2-benzofuranmethamines and other 2-subsituted benzofurans via α-substituted 2-benzofuranmethyl carbocation intermediates Published In Journal of Organic Chemistry Volume 78 Pages 1138 - 1148 ISSN 0022-3263 Altmetric
2013	Fimbricalyx A, a novel phenanthrenone derivative having a rare 2H-benz[e]inden-2-one substructure Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 54 Pages 2085 - 2088 ISSN 0040-4039 Altmetric
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 1305 - 1308 ISSN 1555-9475
2013	Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives Published In Chemical and Pharmaceutical Bulletin Volume 61 Pages 399 - 404 ISSN 0009-2363 Altmetric
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology Volume 148 Pages 1013 - 1017 ISSN 0378-8741 Altmetric
2013	Model support studies toward the total synthesis of the stemona alkaloid stemocurtisine Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 8042 - 8050 ISSN 1464-5416 Altmetric
2013	Parviflorals A–F, trinorcadalenes and bis-trinorcadalenes from the roots of Decaschistia parviflora Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 95 Pages 368 - 374 ISSN 0031-9422 Altmetric
2013	Sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: a new strategy for the synthesis of spiro and bridged heterocycles Published In Organic Letters Volume 15 Pages 5878 - 5881 ISSN 1523-7060 Altmetric
2013	Stereoselective synthesis of α-methylenecyclopentenones via a Diels-Alder/retro-Diels-Alder protocol Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 9270 - 9276 ISSN 1464-5416 Altmetric
2013	Synthesis and inhibitory activities at mGluRs of 3-alkylated and N-alkylated cyclopentyl-glutamate analogues Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 2577 - 2587 ISSN 1464-5416 Altmetric
2013	Synthesis of spirocyclopente-dione anthracene adduct, precursor of the cyclopentenone prostagladins via ring-closing metathesis reaction Published In Chemical Science Transactions Volume 2 Pages 1496 - 1502 Altmetric
2013	The boronic acid Mannich reaction in alkaloid synthesis Published In Pure and Applied Chemistry Volume 85 Pages 1215 - 1225 ISSN 0033-4545 Altmetric
2012	Anticancer and antibacterial activities of the isolated compounds from Solanum spirale Roxb. leaves Published In Chiang Mai Journal of Science Volume 39 Pages 445 - 454 ISSN 0125-2526
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology Volume 143 Pages 310 - 313 ISSN 0378-8741 Altmetric
2012	Antioxidant and anticancer activities from aerial parts of Acalypha indica Linn Published In Chiang Mai University Journal of Natural Sciences Volume 11 Pages 157 - 168
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Chemical composition and biological activities of the essential oil from leaves of Cleidion javanicum Bl Published In Journal of Essential Oil-Bearing Plants Volume 15 Pages 186 - 194
2012	Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 955 - 958 ISSN 1555-9475
2012	Comparison of chemical constituents and antibacterial activities and antioxidant activities of the essential oil from leaves and fruits of Bridelia retusa (L.) A. Juss Published In Journal of Scientific and Industrial Research Volume 71 Pages 733 - 739 ISSN 0022-4456
2012	Highly diastereoselective N-acyliminium ion cyclization reactions of a tethered furan Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 10280 - 10285 ISSN 1464-5416 Altmetric
2012	In vitro evaluation of the antioxidant, antibacterial and anticancer activities of Solanum spirale Roxb. (Solanaceae) Published In Asian Journal of Traditional Medicines Volume 7 Pages 66 - 72
2012	Influence of plantlet age and different soilless culture on acclimatization of Stemona curtisii Hook.f. Published In Asian Journal of Plant Sciences Volume 11 Pages 294 - 299 ISSN 1682-3974 Altmetric
2012	Isolation of tuberospironine A, a novel croomine derivative from Stemona tuberosa Lour. Published In Phytochemistry Letters Volume 5 Pages 358 - 360 ISSN 1874-3900 Altmetric
2012	Isolation, biological activities, and synthesis of the natural casuarines Published In Studies in Natural Products Chemistry Volume 36 Pages 1 - 26 Altmetric
2012	Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide Published In Heterocycles Volume 84 Pages 473 - 492 ISSN 0385-5414 Altmetric
2012	Novel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio Published In BMC Pharmacology Volume 12 Pages 1 - 8 ISSN 1471-2210 Altmetric
2012	Oxidation of acyclic alkenes and allyl and benzyl ethers with DIB/t-BuOOH/Mg(OAc)2 Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 598 - 602 ISSN 1464-5416 Altmetric
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 575 - 580 ISSN 1555-9475
2012	Response of Stemona alkaloid production in Stemona sp. to chitosan and yeast extract elicitors Published In Current Research Journal of Biological Sciences Volume 4 Pages 449 - 454
2012	Structure, biological activities and synthesis of hyacinthacine alkaloids and their stereoisomers Published In Current Organic Synthesis Volume 9 Pages 583 - 612 Altmetric
2012	Synthesis of spirocyclic azacycles from the cyclization of furan tethered N-acyliminium ions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 1207 - 1215 ISSN 1464-5416 Altmetric
2012	Synthesis of stemofoline analogues as acetylcholinesterase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 7103 - 7115 ISSN 1464-5416 Altmetric
2012	The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry Published In Acta Pharmaceutica Volume 62 Pages 181 - 190 ISSN 1330-0075 Altmetric
2011	Stereoselective synthesis of two new trihydroxylated pyrrolidines using a meyer-schuster rearrangement Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 41 Pages 2435 - 2445 ISSN 0039-7911 Altmetric
2011	A comparative study of the essential oil from flowers and fruits of lepisanthes rubiginosa (Roxb.) Leenh Published In Acta Pharmaceutica Sciencia Volume 53 Pages 535 - 542 ISSN 1307-2080
2011	A new isoflavone from Jacaranda obtusifolia H.B.K. ssp. rhombifolia (G.F.W. Meijer) gentry Published In Acta Pharmaceutica Sciencia Volume 53 Pages 181 - 188 ISSN 1307-2080
2011	Antimalarial, Anticancer, Antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl Published In Records of Natural Products Volume 5 Pages 324 - 327
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology Volume 134 Pages 813 - 823 ISSN 0378-8741 Altmetric
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology Volume 137 Pages 730 - 742 ISSN 0378-8741 Altmetric
2011	Influence of salicylic acid on alkaloid production by root cultures of Stemona curtisii Hook. F. Published In Current Research Journal of Biological Science Volume 3 Pages 322 - 325
2011	Isolation of linobiflavonoid, a novel biflavonoid from Linostoma pauciflorum Griff Published In Phytochemistry Letters Volume 4 Pages 383 - 385 ISSN 1874-3900 Altmetric
2011	Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans Published In Journal of Natural Products Volume 74 Pages 60 - 64 ISSN 0163-3864 Altmetric
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 0968-0896 Altmetric
2011	Synthesis of 2-acetyl-5-(1,2,3,4,5,6-hexahydroxyhexyl)thiazoles Published In Monatshefte fuer Chemie: an international journal of chemistry Volume 142 Pages 297 - 303 ISSN 0026-9247 Altmetric
2011	Synthesis of 3-halo-2,5-disubstituted furans via CuX mediated cyclization-halogenation reactions Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 52 Pages 1398 - 1400 ISSN 0040-4039 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1433-7851 Altmetric
2010	Copper-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenols and anilines Published In Journal of Organic Chemistry Volume 75 Pages 3412 - 3419 ISSN 0022-3263 Altmetric
2010	Phytochemical Investigations of Stemona curtisii and Synthetic Studies on Stemocurtisine Alkaloids Published In Journal of Natural Products Volume 73 Pages 1833 - 1838 ISSN 0163-3864 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2010	Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues Published In Journal of Natural Products Volume 73 Pages 935 - 941 ISSN 0163-3864 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 0968-0896 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 0968-0896 Altmetric
2010	Synthesis of 2 '-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 66 Pages 4133 - 4143 ISSN 1464-5416 Altmetric
2010	Synthesis of hyacinthacine B-3 and purported hyacinthacine B-7 Published In Chemical Communications Volume 46 Pages 713 - 715 ISSN 1364-548X Altmetric
2010	Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 66 Pages 9340 - 9347 ISSN 1464-5416 Altmetric
2010	Total synthesis of calystegine B4 Published In European Journal of Organic Chemistry Volume 2010 Pages 3337 - 3344 ISSN 1099-0690 Altmetric
2010	Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor Published In Journal of Organic Chemistry Volume 75 Pages 815 - 824 ISSN 0022-3263 Altmetric
2009	Alkaloids from the roots of Stemona aphylla Published In Journal of Natural Products Volume 72 Pages 848 - 851 ISSN 0163-3864 Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Cytotoxic and Antiplasmodial Compounds from the Roots of Strophioblachia fimbricalyx Published In Journal of Natural Products Volume 72 Pages 1892 - 1894 ISSN 0163-3864 Altmetric
2009	Intermolecular addition reactions of N-acyliminium ions (Part I) Published In Synthesis: journal of synthetic organic chemistry Pages 339 - 368 ISSN 0039-7881 Altmetric
2009	Intermolecular addition reactions of N-acyliminium ions (Part II) Published In Synthesis: journal of synthetic organic chemistry Pages 513 - 541 ISSN 0039-7881 Altmetric
2009	Metal-Catalyzed Cycloisomerization Reactions of cis-4-Hydroxy-5-alkynylpyrrolidinones and cis-5-Hydroxy-6-alkynylpiperidinones: Synthesis of Furo[3,2-b]pyrroles and Furo[3,2-b]pyridines Published In Journal of Organic Chemistry Volume 74 Pages 5523 - 5527 ISSN 0022-3263 Altmetric
2009	ORGANIC-08 Research Highlights Published In Australian Journal of Chemistry: an international journal for chemical science Volume 62 Pages 603 - 604 ISSN 0004-9425 Altmetric
2009	Semisynthesis and biological activity of stemofoline alkaloids Published In Journal of Natural Products Volume 72 Pages 679 - 684 ISSN 0163-3864 Altmetric
2009	Stemofoline ethyl acetate solvate Published In Acta Crystallographica Section E: Structure Reports Online Volume 65 Pages o1878 - o1879 ISSN 1600-5368 Altmetric
2009	Structural revision of stemoburkilline from an E-alkene to a Z-alkene Published In Journal of Natural Products Volume 72 Pages 316 - 318 ISSN 0163-3864 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2009	The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 65 Pages 318 - 327 ISSN 1464-5416 Altmetric
2009	The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 65 Pages 5990 - 6000 ISSN 1464-5416 Altmetric
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters Volume 10 Pages 1315 - 1317 ISSN 1523-7060 Altmetric
2008	Diastereoselective borono-Mannich reactions on cyclic N-acyliminium ions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 1409 - 1419 ISSN 1464-5416 Altmetric
2008	Diastereoselective ritter reactions of chiral cyclic N-Acyliminium ions: synthesis of pyrido- and pyrrolo [2,3-d] oxazoles and 4-Hydroxy-5-N-acylaminopyrrolidines and 5-Hydroxy-6-N-acylaminopiperidines Published In Journal of Organic Chemistry Volume 73 Pages 2943 - 2946 ISSN 0022-3263 Altmetric
2008	Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis Published In Pure and Applied Chemistry Volume 80 Pages 751 - 762 ISSN 0033-4545 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Synthesis of (+)-Uniflorine A: A Structural Reassignment and a Configurational Assignment Published In Organic Letters Volume 10 Pages 2769 - 2771 ISSN 1523-7060 Altmetric
2008	Synthesis of castanospermine Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 2725 - 2732 ISSN 1464-5416 Altmetric
2008	Synthetic and spectroscopic studies on the structures of uniflorines A and B: structural revision to 1,2,6,7-tetrahydroxy-3-hydroxymethylpyrrolizidine alkaloids Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 4868 - 4879 ISSN 1464-5416 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	Free Fatty Acids from the Crude Hexane Extract of the Aerial Parts of Heliotropium indicum Linn. Growing in Phitsanulok, Thailand Published In ACGC Chemical Research Communications Volume 21 Pages 9 - 12 ISSN 1020-5586
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric
2007	Intramolecular versus intermolecular oxidative couplings of ester tethered di-aryl ethers Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 11377 - 11385 ISSN 1464-5416 Altmetric
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Pages 753 - 7536 ISSN 0040-4039 Altmetric
2007	Syntheses of spiro[cyclopropane-1,32-oxindole]-2-carboxylic acid and cyclopropa[c]quinoline-7b-carboxylic acid and their derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 63 Pages 1191 - 1199 ISSN 1464-5416 Altmetric
2007	Synthesis of benzo[c]chromen-6-ones via novel cyclic aryl-Pd(II)-ester enolate intermediates Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 10889 - 10895 ISSN 1464-5416 Altmetric
2007	Synthesis of novel 3'-spirocyclic-oxindole derivatives and assessment of their cytostatic activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 63 Pages 5579 - 5586 ISSN 1464-5416 Altmetric
2007	The pyrido[1,2-a]azepine Stemona alkaloids Published In Maejo International Journal of Science and Technology Volume 1 Pages 157 - 165
2007	The synthesis of 2',2'-bis-benzylisoquinolines and their cytostatic activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 10896 - 10901 ISSN 1464-5416 Altmetric

Chapter

Year	Title
2007	Electrocoagulation in aqueous alcoholic solutions Published In Trends in Elctrochemistry Research Publisher Nova Science Publishers Pages 143 - 160

Investigator On

Year	Title
2018 - 2020	A New Molecular Platform for Catalytic Synthesis of Heterocycles Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	New strategies for the stereoselective synthesis of stemona alkaloids and the Discovery of new bioactive molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Sensitive and multinuclear: dedicated facility for high-throughput characterization of small molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Stereoselective synthesis of bioactive alkaloids for structure elucidation and drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Large scale production of stemona alkaloids for agricultural applications and new drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Anticancer Mutual Prodrugs Activated by Tumour Hypoxia	Sansom, Geraud
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	Gold-catalysed reactions for the synthesis of medicinally important molecules.	Thadkapally, Srinivas
Doctor of Philosophy	Developing Selective Arsenic Anti-Cancer Drugs	Lambert, Jacob
Doctor of Philosophy	Enhanced Scope of the Borono-Mannich Reactions with Methylallenyl Boronate and Organometallic Catalysed Cyclisations	Joyce, Liam
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Investigation into the Stereochemistry of Metal-Catalysed Reactions for the Synthesis of Medicinally Relevant Molecules.	Bird, Melissa
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Development of chemical reactions for the synthesis of bioactive heterocycles	Pham, Pham
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	Development of a Catalytic Asymmetric Fluoro-Petasis Reaction to the Synthesis of Bioactive Fluorinated Heterocycles	Chevis, Philip
Master of Philosophy -SMAH	Synthesis of Broussonetine Alkaloids using 3-alkoxy, 3-acyloxy or 3-trialkylsilyl allyl organ indium, zinc or boron reagents	Alyamani, Asma

Orcid Id

http://orcid.org/0000-0003-0462-0277 (confirmed)

Scopus Id

35496446700

Top Publications

Year	Title
2018	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published in European Journal of Medicinal Chemistry
2018	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published in Angewandte Chemie International Edition
2018	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published in Chemical Communications

Research Areas

Research Overview

The Pyne research group comprises seven PhD students and two Research Associates, some of which are jointly supervised by Prof. Paul Keller and Dr. Chris Hyland. We are working on projects in the following areas:

Discovery of new chemical reactions. Oranoboron reagents and organometallic catalysts are beeing developed for the synthesis of bioactive natural products, drug-like molecules and novel chemical scaffolds for drug discovery (ARC funded with Dr. Chris Hyland). Research Fellow: Dr. Melanie Drew; PhD students: Brendan Bryant, Philip Chevis, Liam Joyce, Srinivas Thadkapally and Quoc Pham.

Discovery and development of new antibacterial agents against pathogenic bacteria (especially Clostridium difficile and Acinetobacter baumannii) (NHMRC funded with Prof. Paul Keller and Assoc. Prof. Haibo Yu). Research Fellow: Dr. Andrew Tague; PhD students: Wendy Cun and Muni Mahadari

Natural products chemistry on traditional medicinal plants from Nigeria and SE Asia. PhD students: Christiana Dawurung, Thanika Promchai and Isaraporn Polbuppha

Selected Publications

Journal Article

Year	Title
2019	1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N -acyliminium ions: Synthetic and computational studies Published In Organic and Biomolecular Chemistry Volume 17 Pages 7025 - 7035 ISSN 1477-0520 Altmetric
2019	A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata Published In Fitoterapia Volume 136 Pages 104175-1 - 104175-6 Altmetric
2019	Alkaloids and styryllactones from Goniothalamus cheliensis Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 157 Pages 8 - 20 ISSN 0031-9422 Altmetric
2019	Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis Published In Journal of Natural Products Volume 82 Pages 283 - 292 ISSN 0163-3864 Altmetric
2019	Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa Published In Journal of Natural Products Volume 82 Pages 2343 - 2348 ISSN 0163-3864 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species Published In Natural Product Research Volume 33 Pages 553 - 556 ISSN 1026-8049 Altmetric
2019	Corrected Structure of Natural Hyacinthacine C 1 via Total Synthesis Published In Journal of Natural Products Volume 82 Pages 358 - 367 ISSN 0163-3864 Altmetric
2019	Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones Published In Chemical Science Volume 10 Pages 9051 - 9056 ISSN 2041-6520 Altmetric
2019	Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes Published In Angewandte Chemie International Edition Volume 58 Pages 2114 - 2119 ISSN 1433-7851 Altmetric
2019	Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines Published In Chemical Communications Volume 55 Pages 6050 - 6053 ISSN 1364-548X Altmetric
2019	Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis Published In Journal of Natural Products Volume 82 Pages 2174 - 2180 ISSN 0163-3864 Altmetric
2019	Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis Published In Journal of Natural Products Volume 82 Pages 101 - 110 ISSN 0163-3864 Altmetric
2019	Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus Published In Natural Product Communications: an international journal for communications and reviews Volume Online First Pages 1 - 5 ISSN 1555-9475 Altmetric
2019	Progress toward the total synthesis of 9β-hydroxyvertine: Construction of an advanced quinolizidine intermediate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 75 Pages 130476-1 - 130476-24 ISSN 1464-5416 Altmetric
2019	Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae) Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 75 Pages 2336 - 2342 ISSN 0040-4039 Altmetric
2019	The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis Published In Current Organic Synthesis Volume 16 Pages 498 - 522 Altmetric
2019	Utilization of electrocoagulation for the isolation of alkaloids from the aerial parts of Stemona aphylla and their mosquitocidal activities against Aedes aegypti Published In Ecotoxicology and Environmental Safety Volume 182 Pages 109448-1 - 109448-8 ISSN 0147-6513 Altmetric
2019	Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leaf extracts of Uvaria lurida Published In Fitoterapia Volume 138 Pages 104340 - 104340 ISSN 1971-551X Altmetric
2019	α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis Published In Journal of Natural Products Volume 82 Pages 741 - 747 ISSN 0163-3864 Altmetric
2018	12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea Published In Natural Product Communications: an international journal for communications and reviews Volume 13 Pages 1327 - 1328 ISSN 1555-9475
2018	A pharmacological strategy using stemofoline for more efficacious chemotherapeutic treatments against human multidrug resistant leukemic cells Published In Asian Pacific Journal of Cancer Prevention (APJCP) Volume 19 Pages 3533 - 3543 ISSN 1513-7368 Altmetric
2018	Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii Published In Phytochemistry Letters Volume 23 Pages 33 - 37 ISSN 1874-3900 Altmetric
2018	Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa Published In Journal of Natural Products Volume 81 Pages 1835 - 1840 ISSN 0163-3864 Altmetric
2018	Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1026-8049 Altmetric
2018	Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU Published In Fitoterapia Volume 130 Pages 219 - 224 Altmetric
2018	Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum Published In Natural Product Research Volume Online First Pages 1 - 6 ISSN 1026-8049 Altmetric
2018	Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis Published In Fitoterapia Volume 130 Pages 198 - 202 Altmetric
2018	Gold- and Silver-Catalysed Cyclisation Reactions of β-Amino Allenes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 71 Pages 682 - 689 ISSN 0004-9425 Altmetric
2018	Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii Published In Natural Product Research Volume Online First Pages 1 - 5 ISSN 1026-8049 Altmetric
2018	Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells Published In Fitoterapia Volume 124 Pages 34 - 41 Altmetric
2018	Total Synthesis of Natural Hyacinthacine C5, and six Related Hyacinthacine C5 Epimers Published In Journal of Organic Chemistry Volume 83 Pages 5558 - 5576 ISSN 0022-3263 Altmetric
2017	2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae) Published In Fitoterapia Volume 120 Pages 103 - 107 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Allenylation and propargylation reactions of ketones, aldehydes, imines, and iminium ions using organoboronates and related derivatives Published In Synthesis: journal of synthetic organic chemistry Volume 49 Pages 1461 - 1480 ISSN 0039-7881 Altmetric
2017	Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1026-8049 Altmetric
2017	Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1073 - 1076 ISSN 1555-9475
2017	Hybrid flavan–flavanones from Friesodielsia desmoides and their inhibitory activities against nitric oxide production Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 17545 - 17550 ISSN 2046-2069 Altmetric
2017	Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships Published In Phytomedicine Volume 34 Pages 182 - 190 ISSN 1618-095X Altmetric
2017	Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of L-α-Amino Aldehydes Published In Journal of Organic Chemistry Volume 82 Pages 6819 - 6830 ISSN 0022-3263 Altmetric
2017	Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytotoxic activities of Graptophyllum pictum (L.) Griff Published In Chiang Mai Journal of Science Volume 44 Pages 193 - 202 ISSN 0125-2526
2017	Phytochemical, Synthetic and Biological Studies on Stemona and Stichoneuron Plants and Alkaloids: A Personal Perspective Published In Natural Product Communications: an international journal for communications and reviews Volume 12 Pages 1365 - 1369 ISSN 1555-9475
2017	Scalemic caged xanthones isolated from the stem bark extract of Garcinia propinqua Published In Journal of Natural Products Volume 80 Pages 1658 - 1667 ISSN 0163-3864 Altmetric
2017	Two phenylethanoid glycosides, Parvifloroside A and B, isolated from Barleria strigosa Published In Chiang Mai Journal of Science Volume 44 Pages 168 - 175 ISSN 0125-2526
2016	A concise synthesis of furo[3,2-c]coumarins catalyzed by nanocrystalline ZnZr4(PO4)6 ceramics under microwave irradiation Published In Journal of the Iranian Chemical Society Volume 13 Pages 1439 - 1448 ISSN 1735-207X Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata Published In Journal of Natural Products Volume 79 Pages 978 - 983 ISSN 0163-3864 Altmetric
2016	Antimalarial polyoxygenated and prenylated xanthones from the leaves and branches of Garcinia mckeaniana Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 72 Pages 6837 - 6842 ISSN 1464-5416 Altmetric
2016	Determination of antioxidant and anticancer activities together with total phenol and flavonoid contents of Cleidion javanicum Bl. And Bridelia retusa (L.) A. Juss Published In Chiang Mai Journal of Science Volume 43 Pages 534 - 545 ISSN 0125-2526
2016	Effects of chitosan and salicylic acid on stemona alkaloid production in hydroponic culture of stemona curtisii Hook. f. Published In Chiang Mai Journal of Science Volume 43 Pages 1070 - 1076 ISSN 0125-2526
2016	Essential oil of solanum spirale fruits and its biological activities Published In Chiang Mai Journal of Science Volume 43 Pages 546 - 554 ISSN 0125-2526
2016	Synthesis of bridged heterocycles via sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: mechanistic and computational studies Published In Journal of Organic Chemistry Volume 81 Pages 1434 - 1449 ISSN 0022-3263 Altmetric
2016	Synthesis of furo[3,2-c]coumarins under microwave irradiation using nano-CoFe₂O₄@SiO₂–PrNH₂ as an efficient and magnetically reusable catalyst Published In Khimiya Geterotsiklicheskikh Soedinenii Volume 52 Pages 288 - 293 ISSN 0009-3122 Altmetric
2016	Synthesis of α-propargylglycinates using the borono-mannich reaction with pinacol allenylboronate and potassium allenyltrifluoroborate Published In European Journal of Organic Chemistry Volume 2016 Pages 3765 - 3772 ISSN 1099-0690 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2016	The isolation of lutein and lutein 3'-methyl ether from peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1793 - 1795 ISSN 1555-9475
2016	Two new bioactive iridoids from Rothmannia wittii Published In Fitoterapia Volume 113 Pages 97 - 101 ISSN 1971-551X Altmetric
2015	Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities Published In Phytochemistry Letters Volume 11 Pages 157 - 162 Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum Published In Natural Product Communications: an international journal for communications and reviews Volume 10 Pages 1175 - 1177 ISSN 1555-9475
2015	Diastereoselective synthesis of the A-B-C tricyclic ring structure of stemocurtisine Published In European Journal of Organic Chemistry Volume 2015 Pages 7682 - 7694 ISSN 1099-0690 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Regioselective and diastereoselective borono-mannich reactions with pinacol allenylboronate Published In Organic Letters Volume 17 Pages 778 - 781 ISSN 1523-7060 Altmetric
2015	Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of p-glycoprotein function Published In Basic and Clinical Pharmacology and Toxicology Volume 116 Pages 390 - 397 ISSN 1742-7835 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2015	The chemical constituents and biological activities of the essential oil and the extracts from leaves of Gynura divaricata (L.) DC. growing in Thailand Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 543 - 555 Altmetric
2015	The chemical constituents and the cytotoxicity, antioxidant and antibacterial activities of the essential oil of Graptophyllum pictum (L.) Griff Published In Journal of Essential Oil Bearing Plants Volume 18 Pages 11 - 17 Altmetric
2014	A new 1,6-benzoxazocine-5-one alkaloid isolated from the aerial parts of Peristrophe lanceolaria Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 1433 - 1435 ISSN 1555-9475
2014	Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities Published In Journal of Natural Products Volume 77 Pages 894 - 901 ISSN 0163-3864 Altmetric
2014	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa Published In Fitoterapia Volume 98 Pages 179 - 183 ISSN 1971-551X Altmetric
2014	Carbazole alkaloids and coumarins from the roots of Clausena guillauminii Published In Phytochemistry Letters Volume 9 Pages 113 - 116 ISSN 1874-3900 Altmetric
2014	Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 475 - 478 ISSN 0040-4039 Altmetric
2014	Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling Published In Journal of Chemical and Pharmaceutical Research Volume 6 Pages 544 - 548
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	The boronic acid Mannich reaction Published In Organic Reactions Volume 83 Pages 211 - 498 Altmetric
2014	Total synthesis of hyacinthacines B3, B4, and B 5 and purported hyacinthacine B7, 7-epi-hyacinthacine B7, and 7a-epi-hyacinthacine B3 from a common precursor Published In Journal of Organic Chemistry Volume 79 Pages 4569 - 4581 ISSN 0022-3263 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric
2013	6-Hydroxy-5,6-seco-stemocurtisine: a novel seco-stemocurtisine-type alkaloid Published In Phytochemistry Letters Volume 6 Pages 602 - 605 ISSN 1874-3900 Altmetric
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology Volume 150 Pages 953 - 959 ISSN 0378-8741 Altmetric
2013	Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 695 - 698 ISSN 1555-9475
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology Volume 148 Pages 305 - 310 ISSN 0378-8741 Altmetric
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 733 - 736 ISSN 1555-9475
2013	Bioactive compounds from the roots of Strophioblachia fimbricalyx Published In Journal of Natural Products Volume 76 Pages 1358 - 1364 ISSN 0163-3864 Altmetric
2013	Chemical constituents and biological activities of Garcinia cowa Roxb Published In Maejo International Journal of Science and Technology Volume 7 Pages 212 - 231
2013	Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities Published In Organic and Biomolecular Chemistry Volume 11 Pages 3826 - 3833 ISSN 1477-0520 Altmetric
2013	Concise synthesis of α-substituted 2-benzofuranmethamines and other 2-subsituted benzofurans via α-substituted 2-benzofuranmethyl carbocation intermediates Published In Journal of Organic Chemistry Volume 78 Pages 1138 - 1148 ISSN 0022-3263 Altmetric
2013	Fimbricalyx A, a novel phenanthrenone derivative having a rare 2H-benz[e]inden-2-one substructure Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 54 Pages 2085 - 2088 ISSN 0040-4039 Altmetric
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 1305 - 1308 ISSN 1555-9475
2013	Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives Published In Chemical and Pharmaceutical Bulletin Volume 61 Pages 399 - 404 ISSN 0009-2363 Altmetric
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology Volume 148 Pages 1013 - 1017 ISSN 0378-8741 Altmetric
2013	Model support studies toward the total synthesis of the stemona alkaloid stemocurtisine Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 8042 - 8050 ISSN 1464-5416 Altmetric
2013	Parviflorals A–F, trinorcadalenes and bis-trinorcadalenes from the roots of Decaschistia parviflora Published In Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology Volume 95 Pages 368 - 374 ISSN 0031-9422 Altmetric
2013	Sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: a new strategy for the synthesis of spiro and bridged heterocycles Published In Organic Letters Volume 15 Pages 5878 - 5881 ISSN 1523-7060 Altmetric
2013	Stereoselective synthesis of α-methylenecyclopentenones via a Diels-Alder/retro-Diels-Alder protocol Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 9270 - 9276 ISSN 1464-5416 Altmetric
2013	Synthesis and inhibitory activities at mGluRs of 3-alkylated and N-alkylated cyclopentyl-glutamate analogues Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 69 Pages 2577 - 2587 ISSN 1464-5416 Altmetric
2013	Synthesis of spirocyclopente-dione anthracene adduct, precursor of the cyclopentenone prostagladins via ring-closing metathesis reaction Published In Chemical Science Transactions Volume 2 Pages 1496 - 1502 Altmetric
2013	The boronic acid Mannich reaction in alkaloid synthesis Published In Pure and Applied Chemistry Volume 85 Pages 1215 - 1225 ISSN 0033-4545 Altmetric
2012	Anticancer and antibacterial activities of the isolated compounds from Solanum spirale Roxb. leaves Published In Chiang Mai Journal of Science Volume 39 Pages 445 - 454 ISSN 0125-2526
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology Volume 143 Pages 310 - 313 ISSN 0378-8741 Altmetric
2012	Antioxidant and anticancer activities from aerial parts of Acalypha indica Linn Published In Chiang Mai University Journal of Natural Sciences Volume 11 Pages 157 - 168
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Chemical composition and biological activities of the essential oil from leaves of Cleidion javanicum Bl Published In Journal of Essential Oil-Bearing Plants Volume 15 Pages 186 - 194
2012	Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 955 - 958 ISSN 1555-9475
2012	Comparison of chemical constituents and antibacterial activities and antioxidant activities of the essential oil from leaves and fruits of Bridelia retusa (L.) A. Juss Published In Journal of Scientific and Industrial Research Volume 71 Pages 733 - 739 ISSN 0022-4456
2012	Highly diastereoselective N-acyliminium ion cyclization reactions of a tethered furan Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 10280 - 10285 ISSN 1464-5416 Altmetric
2012	In vitro evaluation of the antioxidant, antibacterial and anticancer activities of Solanum spirale Roxb. (Solanaceae) Published In Asian Journal of Traditional Medicines Volume 7 Pages 66 - 72
2012	Influence of plantlet age and different soilless culture on acclimatization of Stemona curtisii Hook.f. Published In Asian Journal of Plant Sciences Volume 11 Pages 294 - 299 ISSN 1682-3974 Altmetric
2012	Isolation of tuberospironine A, a novel croomine derivative from Stemona tuberosa Lour. Published In Phytochemistry Letters Volume 5 Pages 358 - 360 ISSN 1874-3900 Altmetric
2012	Isolation, biological activities, and synthesis of the natural casuarines Published In Studies in Natural Products Chemistry Volume 36 Pages 1 - 26 Altmetric
2012	Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide Published In Heterocycles Volume 84 Pages 473 - 492 ISSN 0385-5414 Altmetric
2012	Novel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio Published In BMC Pharmacology Volume 12 Pages 1 - 8 ISSN 1471-2210 Altmetric
2012	Oxidation of acyclic alkenes and allyl and benzyl ethers with DIB/t-BuOOH/Mg(OAc)2 Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 598 - 602 ISSN 1464-5416 Altmetric
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 575 - 580 ISSN 1555-9475
2012	Response of Stemona alkaloid production in Stemona sp. to chitosan and yeast extract elicitors Published In Current Research Journal of Biological Sciences Volume 4 Pages 449 - 454
2012	Structure, biological activities and synthesis of hyacinthacine alkaloids and their stereoisomers Published In Current Organic Synthesis Volume 9 Pages 583 - 612 Altmetric
2012	Synthesis of spirocyclic azacycles from the cyclization of furan tethered N-acyliminium ions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 1207 - 1215 ISSN 1464-5416 Altmetric
2012	Synthesis of stemofoline analogues as acetylcholinesterase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 7103 - 7115 ISSN 1464-5416 Altmetric
2012	The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry Published In Acta Pharmaceutica Volume 62 Pages 181 - 190 ISSN 1330-0075 Altmetric
2011	Stereoselective synthesis of two new trihydroxylated pyrrolidines using a meyer-schuster rearrangement Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 41 Pages 2435 - 2445 ISSN 0039-7911 Altmetric
2011	A comparative study of the essential oil from flowers and fruits of lepisanthes rubiginosa (Roxb.) Leenh Published In Acta Pharmaceutica Sciencia Volume 53 Pages 535 - 542 ISSN 1307-2080
2011	A new isoflavone from Jacaranda obtusifolia H.B.K. ssp. rhombifolia (G.F.W. Meijer) gentry Published In Acta Pharmaceutica Sciencia Volume 53 Pages 181 - 188 ISSN 1307-2080
2011	Antimalarial, Anticancer, Antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl Published In Records of Natural Products Volume 5 Pages 324 - 327
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology Volume 134 Pages 813 - 823 ISSN 0378-8741 Altmetric
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology Volume 137 Pages 730 - 742 ISSN 0378-8741 Altmetric
2011	Influence of salicylic acid on alkaloid production by root cultures of Stemona curtisii Hook. F. Published In Current Research Journal of Biological Science Volume 3 Pages 322 - 325
2011	Isolation of linobiflavonoid, a novel biflavonoid from Linostoma pauciflorum Griff Published In Phytochemistry Letters Volume 4 Pages 383 - 385 ISSN 1874-3900 Altmetric
2011	Phytochemical studies on Stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans Published In Journal of Natural Products Volume 74 Pages 60 - 64 ISSN 0163-3864 Altmetric
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 0968-0896 Altmetric
2011	Synthesis of 2-acetyl-5-(1,2,3,4,5,6-hexahydroxyhexyl)thiazoles Published In Monatshefte fuer Chemie: an international journal of chemistry Volume 142 Pages 297 - 303 ISSN 0026-9247 Altmetric
2011	Synthesis of 3-halo-2,5-disubstituted furans via CuX mediated cyclization-halogenation reactions Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 52 Pages 1398 - 1400 ISSN 0040-4039 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1433-7851 Altmetric
2010	Copper-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenols and anilines Published In Journal of Organic Chemistry Volume 75 Pages 3412 - 3419 ISSN 0022-3263 Altmetric
2010	Phytochemical Investigations of Stemona curtisii and Synthetic Studies on Stemocurtisine Alkaloids Published In Journal of Natural Products Volume 73 Pages 1833 - 1838 ISSN 0163-3864 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2010	Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues Published In Journal of Natural Products Volume 73 Pages 935 - 941 ISSN 0163-3864 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 0968-0896 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 0968-0896 Altmetric
2010	Synthesis of 2 '-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 66 Pages 4133 - 4143 ISSN 1464-5416 Altmetric
2010	Synthesis of hyacinthacine B-3 and purported hyacinthacine B-7 Published In Chemical Communications Volume 46 Pages 713 - 715 ISSN 1364-548X Altmetric
2010	Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 66 Pages 9340 - 9347 ISSN 1464-5416 Altmetric
2010	Total synthesis of calystegine B4 Published In European Journal of Organic Chemistry Volume 2010 Pages 3337 - 3344 ISSN 1099-0690 Altmetric
2010	Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor Published In Journal of Organic Chemistry Volume 75 Pages 815 - 824 ISSN 0022-3263 Altmetric
2009	Alkaloids from the roots of Stemona aphylla Published In Journal of Natural Products Volume 72 Pages 848 - 851 ISSN 0163-3864 Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Cytotoxic and Antiplasmodial Compounds from the Roots of Strophioblachia fimbricalyx Published In Journal of Natural Products Volume 72 Pages 1892 - 1894 ISSN 0163-3864 Altmetric
2009	Intermolecular addition reactions of N-acyliminium ions (Part I) Published In Synthesis: journal of synthetic organic chemistry Pages 339 - 368 ISSN 0039-7881 Altmetric
2009	Intermolecular addition reactions of N-acyliminium ions (Part II) Published In Synthesis: journal of synthetic organic chemistry Pages 513 - 541 ISSN 0039-7881 Altmetric
2009	Metal-Catalyzed Cycloisomerization Reactions of cis-4-Hydroxy-5-alkynylpyrrolidinones and cis-5-Hydroxy-6-alkynylpiperidinones: Synthesis of Furo[3,2-b]pyrroles and Furo[3,2-b]pyridines Published In Journal of Organic Chemistry Volume 74 Pages 5523 - 5527 ISSN 0022-3263 Altmetric
2009	ORGANIC-08 Research Highlights Published In Australian Journal of Chemistry: an international journal for chemical science Volume 62 Pages 603 - 604 ISSN 0004-9425 Altmetric
2009	Semisynthesis and biological activity of stemofoline alkaloids Published In Journal of Natural Products Volume 72 Pages 679 - 684 ISSN 0163-3864 Altmetric
2009	Stemofoline ethyl acetate solvate Published In Acta Crystallographica Section E: Structure Reports Online Volume 65 Pages o1878 - o1879 ISSN 1600-5368 Altmetric
2009	Structural revision of stemoburkilline from an E-alkene to a Z-alkene Published In Journal of Natural Products Volume 72 Pages 316 - 318 ISSN 0163-3864 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2009	The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 65 Pages 318 - 327 ISSN 1464-5416 Altmetric
2009	The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 65 Pages 5990 - 6000 ISSN 1464-5416 Altmetric
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters Volume 10 Pages 1315 - 1317 ISSN 1523-7060 Altmetric
2008	Diastereoselective borono-Mannich reactions on cyclic N-acyliminium ions Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 1409 - 1419 ISSN 1464-5416 Altmetric
2008	Diastereoselective ritter reactions of chiral cyclic N-Acyliminium ions: synthesis of pyrido- and pyrrolo [2,3-d] oxazoles and 4-Hydroxy-5-N-acylaminopyrrolidines and 5-Hydroxy-6-N-acylaminopiperidines Published In Journal of Organic Chemistry Volume 73 Pages 2943 - 2946 ISSN 0022-3263 Altmetric
2008	Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis Published In Pure and Applied Chemistry Volume 80 Pages 751 - 762 ISSN 0033-4545 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Synthesis of (+)-Uniflorine A: A Structural Reassignment and a Configurational Assignment Published In Organic Letters Volume 10 Pages 2769 - 2771 ISSN 1523-7060 Altmetric
2008	Synthesis of castanospermine Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 2725 - 2732 ISSN 1464-5416 Altmetric
2008	Synthetic and spectroscopic studies on the structures of uniflorines A and B: structural revision to 1,2,6,7-tetrahydroxy-3-hydroxymethylpyrrolizidine alkaloids Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 4868 - 4879 ISSN 1464-5416 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	Free Fatty Acids from the Crude Hexane Extract of the Aerial Parts of Heliotropium indicum Linn. Growing in Phitsanulok, Thailand Published In ACGC Chemical Research Communications Volume 21 Pages 9 - 12 ISSN 1020-5586
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric
2007	Intramolecular versus intermolecular oxidative couplings of ester tethered di-aryl ethers Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 11377 - 11385 ISSN 1464-5416 Altmetric
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Pages 753 - 7536 ISSN 0040-4039 Altmetric
2007	Syntheses of spiro[cyclopropane-1,32-oxindole]-2-carboxylic acid and cyclopropa[c]quinoline-7b-carboxylic acid and their derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 63 Pages 1191 - 1199 ISSN 1464-5416 Altmetric
2007	Synthesis of benzo[c]chromen-6-ones via novel cyclic aryl-Pd(II)-ester enolate intermediates Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 10889 - 10895 ISSN 1464-5416 Altmetric
2007	Synthesis of novel 3'-spirocyclic-oxindole derivatives and assessment of their cytostatic activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 63 Pages 5579 - 5586 ISSN 1464-5416 Altmetric
2007	The pyrido[1,2-a]azepine Stemona alkaloids Published In Maejo International Journal of Science and Technology Volume 1 Pages 157 - 165
2007	The synthesis of 2',2'-bis-benzylisoquinolines and their cytostatic activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Pages 10896 - 10901 ISSN 1464-5416 Altmetric

Chapter

Year	Title
2007	Electrocoagulation in aqueous alcoholic solutions Published In Trends in Elctrochemistry Research Publisher Nova Science Publishers Pages 143 - 160

Investigator On

Year	Title
2018 - 2020	A New Molecular Platform for Catalytic Synthesis of Heterocycles Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2013	New strategies for the stereoselective synthesis of stemona alkaloids and the Discovery of new bioactive molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Sensitive and multinuclear: dedicated facility for high-throughput characterization of small molecules Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Stereoselective synthesis of bioactive alkaloids for structure elucidation and drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Large scale production of stemona alkaloids for agricultural applications and new drug discovery Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Anticancer Mutual Prodrugs Activated by Tumour Hypoxia	Sansom, Geraud
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	Gold-catalysed reactions for the synthesis of medicinally important molecules.	Thadkapally, Srinivas
Doctor of Philosophy	Developing Selective Arsenic Anti-Cancer Drugs	Lambert, Jacob
Doctor of Philosophy	Enhanced Scope of the Borono-Mannich Reactions with Methylallenyl Boronate and Organometallic Catalysed Cyclisations	Joyce, Liam
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Investigation into the Stereochemistry of Metal-Catalysed Reactions for the Synthesis of Medicinally Relevant Molecules.	Bird, Melissa
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Development of chemical reactions for the synthesis of bioactive heterocycles	Pham, Pham
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	Development of a Catalytic Asymmetric Fluoro-Petasis Reaction to the Synthesis of Bioactive Fluorinated Heterocycles	Chevis, Philip
Master of Philosophy -SMAH	Synthesis of Broussonetine Alkaloids using 3-alkoxy, 3-acyloxy or 3-trialkylsilyl allyl organ indium, zinc or boron reagents	Alyamani, Asma

Orcid Id

http://orcid.org/0000-0003-0462-0277 (confirmed)

Scopus Id

35496446700

Pyne, Stephen G. Senior Professor

Professor of Chemistry

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Overview

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Research Overview

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Advisees

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