Sluyter, Ronald

Top Publications

Year	Title
2017	The P2X7 Receptor
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published in Pharmacological Reviews
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published in Mediators of Inflammation

Research Areas

Research Overview

Ronald Sluyter is Head of the Immunology and Cell Signalling Group. His group explores the roles P2X7 and other purinergic signalling molecules in human and veterinary health and disease including graft-versus-host disease, cancer immunology, motor neurone disease and pain.

Head Of

Illawarra Health and Medical Research Institute Head of Immunology and Cell Signalling Group 2008 -

Member Of

Molecular Horizons Member 2018 -
The Australian and New Zealand Purine Club Co-President 2018 -
The Centre for Oncology Education and Research Translation (CONCERT) Member 2017 -
The Australian Physiological Society Member 2009 -
The Australian and New Zealand Society for Immunology Member 1993 -
Centre for Medical and Molecular Bioscience Member 2008 - 2018

Selected Publications

Journal Article

Year	Title
2020	Association of a P2RX7 gene missense variant with brachycephalic dog breeds Published In Animal Genetics Volume 51 Pages 127 - 131 ISSN 0268-9146 Altmetric
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published In Clinical science (London, England : 1979) Volume 134 Pages 207 - 223 Altmetric
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume Online First Pages 1 - 16 ISSN 1573-9546 Altmetric
2019	Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels Published In Microfluidics and Nanofluidics Volume 23 Pages 41-1 - 41-9 ISSN 1613-4982 Altmetric
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology Volume 54 Pages 38 - 46 ISSN 0966-3274 Altmetric
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology Volume 336 Pages 12 - 19 ISSN 0008-8749 Altmetric
2019	Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union Published In Critical Reviews in Toxicology Volume Online First Pages 1 - 18 ISSN 1040-8444 Altmetric
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology Volume Online First Pages 1 - 14 ISSN 0818-9641 Altmetric
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology Volume 72 Pages 479 - 486 ISSN 1567-5769 Altmetric
2018	A portable, hand-powered microfluidic device for sorting of biological particles Published In Microfluidics and Nanofluidics Volume 22 Pages 1 - 10 ISSN 1613-4982 Altmetric
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume 14 Pages S57 - S58 ISSN 1573-9546 Altmetric
2017	Effects of Gold Nanoparticles and Gold Anti-Arthritic Compounds on Inflammation Marker Expression in Macrophages Published In Australian Journal of Chemistry: an international journal for chemical science Volume 70 Pages 1057 - 1068 ISSN 0004-9425 Altmetric
2017	High-Throughput Separation of White Blood Cells From Whole Blood Using Inertial Microfluidics Published In IEEE Transactions on Biomedical Circuits and Systems Volume 11 Pages 1422 - 1430 ISSN 1932-4545 Altmetric
2017	On-Chip Microparticle and Cell Washing Using Coflow of Viscoelastic Fluid and Newtonian Fluid Published In Analytical Chemistry Volume 89 Pages 9574 - 9582 ISSN 0003-2700 Altmetric
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ Volume 5 Pages e3064-1 - e3064-29 Altmetric
2017	P2X7 receptor antagonism in amyotrophic lateral sclerosis Published In Neural Regeneration Research Volume 12 Pages 749 - 750 Altmetric
2017	Probenecid directly impairs activation of the canine P2X7 receptor Published In Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication Volume 36 Pages 736 - 744 ISSN 1525-7770 Altmetric
2017	Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 3461 - 3469 ISSN 2046-2069 Altmetric
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology Volume 190 Pages 79 - 95 ISSN 0009-9104 Altmetric
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling Volume 13 Pages 405 - 415 ISSN 1573-9546 Altmetric
2016	Continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays Published In Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering Volume 16 Pages 3919 - 3928 ISSN 1473-0197 Altmetric
2016	Editorial: Roles of ion channels in immune cells Published In Frontiers in Immunology Volume 7 Pages 48-1 - 48-2 ISSN 1664-3224 Altmetric
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation Volume 2016 Page p. 2097219 ISSN 0962-9351 Altmetric
2016	P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes Published In World Journal of Hematology Volume 5 Pages 88 - 93 Altmetric
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology Volume 5 Pages 72 - 83 Altmetric
2016	Roles of extracellular nucleotides and P2 receptors in ectodomain shedding Published In Cellular and Molecular Life Sciences Volume 73 Pages 4159 - 4173 ISSN 1420-682X Altmetric
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology Volume 93 Pages 77 - 85 ISSN 0818-9641 Altmetric
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry Volume 142 Pages 28 - 38 ISSN 0162-0134 Altmetric
2015	P2X and P2Y receptor signaling in red blood cells Published In Frontiers in Molecular Biosciences Volume 2 Pages 60-1 - 60-7 Altmetric
2015	Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging Published In Transfusion Volume 55 Pages 1946 - 1954 ISSN 1537-2995 Altmetric
2014	Extracellular adenosine 5'-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood Published In Veterinary Immunology and Immunopathology Volume 157 Pages 105 - 110 ISSN 0165-2427 Altmetric
2014	Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel Published In Scientific Reports Volume 4 Pages 1 - 9 ISSN 2045-2322 Altmetric
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology Volume 92 Pages A5 - A5 ISSN 0818-9641 Altmetric
2014	On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser Published In Scientific Reports Volume 4 Pages 1 - 8 ISSN 2045-2322 Altmetric
2014	P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells Published In Inflammation and Cell Signaling Volume 1 Pages 44 - 49 Altmetric
2014	Polymorphic variants of the P2X7 receptor in the domestic dog Published In Jacobs Journal of Veterinary Science and Research Volume 1 Page p. 008
2014	Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism Published In PLoS One Volume 9 Pages e93058-1 - e93058-8 ISSN 1932-6203 Altmetric
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published In Physiological Genomics Volume 46 Pages 512 - 522 ISSN 1094-8341 Altmetric
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research Volume 1 Pages 1 - 2
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published In Pharmacological Reviews Volume 66 Pages 638 - 675 ISSN 0031-6997 Altmetric
2013	CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation Published In Purinergic Signalling Volume 9 Pages 609 - 619 ISSN 1573-9546 Altmetric
2013	Human P2X7 receptor activation induces ADAM10-mediated shedding of CD23 and CXCL16 (P4137) Published In Journal of Immunology Volume 190 Pages 112.2 - 112.2 ISSN 0022-1767
2013	Human P2X7 receptor activation induces the rapid shedding of CXCL16 Published In Biochemical and Biophysical Research Communications Volume 432 Pages 626 - 631 ISSN 0006-291X Altmetric
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published In Mediators of Inflammation Volume 2013 Pages 271813-1 - 271813-18 ISSN 0962-9351 Altmetric
2013	P2X7 receptor activation induces reactive oxygen species formation in erythroid cells Published In Purinergic Signalling Volume 9 Pages 101 - 112 ISSN 1573-9546 Altmetric
2012	Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes Published In Veterinary Immunology and Immunopathology Volume 149 Pages 86 - 91 ISSN 0165-2427 Altmetric
2012	Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells Published In Veterinary Immunology and Immunopathology Volume 150 Pages 228 - 233 ISSN 0165-2427 Altmetric
2012	P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells Published In Purinergic Signalling Volume 8 Pages 669 - 676 ISSN 1573-9546 Altmetric
2011	Significance of P2X7 receptor variants to human health and disease Published In Recent Patents on DNA and Gene Sequences Volume 5 Pages 41 - 54 ISSN 1872-2156
2011	The human P2X7 receptor and its role in innate immunity Published In Tissue Antigens: immune response genetics Volume 78 Pages 321 - 332 ISSN 0001-2815 Altmetric
2010	Functional significance of P2RX7 polymorphisms associated with affective mood disorders Published In Journal of Psychiatric Research Volume 44 Pages 1116 - 1117 ISSN 0022-3956 Altmetric
2010	Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors Published In Experimental Dermatology Volume 19 Pages E151 - E157 ISSN 0906-6705 Altmetric
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects Volume 1800 Pages 1173 - 1182 ISSN 0304-4165 Altmetric
2010	P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells Published In BBA: Biomembranes Volume 1798 Pages 1797 - 1804 ISSN 0005-2736 Altmetric
2010	TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS inleukemic THP-1 monocytes Published In Biochimica et Biophysica Acta: international journal of biochemistry and biophysics Volume 1798 Pages 2058 - 2066 ISSN 0006-3002 Altmetric
2010	Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion Published In The FASEB Journal Volume 24 Pages 2916 - 2927 ISSN 0892-6638 Altmetric
2009	Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure Published In International Journal of Cardiology Volume 137 Pages 81 - 83 Altmetric
2009	The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types Published In Purinergic Signalling Volume 5 Pages 385 - 394 ISSN 1573-9546 Altmetric
2008	"Host tissue damage" signal ATP impairs IL-12 and IFNy secretion in LPS stimulated whole human blood Published In Intensive Care Medicine Volume 34 Pages 1891 - 1897 ISSN 0342-4642 Altmetric
2008	Comparison of the P2X7 receptor in canine and human erythrocytes and mononuclear leukocytes Published In Purinergic Signalling Volume 4 Pages S149 - S149 ISSN 1573-9546 Altmetric
2008	Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist Published In Biochemical and Biophysical Research Communications Volume 365 Pages 515 - 520 ISSN 0006-291X Altmetric
2007	A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis Published In American Journal of Respiratory and Critical Care Medicine Volume 175 Pages 360 - 366 ISSN 1073-449X Altmetric
2007	A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry Published In Journal of Immunological Methods Volume 325 Pages 67 - 77 ISSN 0022-1759 Altmetric
2007	Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes Published In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Volume 293 Pages R2090 - R2098 ISSN 0363-6119 Altmetric
2007	P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes Published In Biochemical and Biophysical Research Communications Volume 355 Pages 169 - 173 ISSN 0006-291X Altmetric
2007	Rottlerin inhibits P2X7 receptor-stimulated phospholipase D activity in chronic lumphocytic leukaemia B-lymphocytes Published In Immunology and Cell Biology Volume 85 Pages 68 - 72 ISSN 0818-9641 Altmetric

Chapter

Year	Title
2017	The P2X7 Receptor Published In Advances in Experimental Medicine and Biology: Protein Reviews Publisher Singapore: Springer Nature Pages 17 - 53 ISBN 9789811076107 Altmetric
2007	The genetic control of susceptibility to Mycobacterium tuberculosis Published In Decoding the Genomic Control of Immune Reactions Publisher John Wiley 7 Sons, Ltd Pages 79 - 89

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017 - 2018	Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Molecular mechanisms in coagulation and thrombotic events in dogs and cats Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Role of P2X Receptors in Chronic Pain Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: OAK Project Grant
2011	Microprobe XFM and XAS of gold anti-arthritic agents in macrophages Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	NALP3 inflammasome activation in canine health and disease Awarded by: Canine Research Foundation Funding Scheme: Research Grant
2010	Understanding mechanisms involved in canine autoimmune and inflammatory disorders Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: Research Grant
	Genetic variants of damage-associated molecular pattern receptor P2X7 in dogs: potential role in inflammatory and bone disorders, and in pain Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterisation of P2X4 and P2Y12 receptors in humans and companion animals	Sophocleous, Reece
Doctor of Philosophy	Mapping Programmed cell death of neutrophils in response to Group A Streptococcal infection	Williams, Jonathan
Doctor of Philosophy	Therapeutics Strategies to Prevent Graft-versus-Host Disease	Adhikary, Sam
Doctor of Philosophy	Next Generation Sunscreen Products Optimised for Australian Conditions	Morlando, Alexander
Doctor of Philosophy	Characterising the Interaction Between Group A Streptococcus and Hyaluronin	McEwan, Tahnee
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter
Doctor of Philosophy	Therapeutic Strategies to Prevent Graft-versus-Host Disease but Maintain Graft-versus-Tumour Immunity Following Allogeneic Stem Cell Transplantation	Bird, Katrina

Organizer Of Event

Professional Service Activities

School of Chemistry and Molecular Bioscience Safety Committee Member 2019 -
Australian and New Zealand Purine Club Co-President 2018 -
Faculty of Science, Medicine and Health Member of Faculty Research Committee 2015 -
Faculty of Science, Medicne and Health Chair of Safe@Work Committee 2008 -
National Health and Medical Research Council (NHMRC) Grant Review Panel 2019
National Health and Medical Research Council (NHMRC) Assigners Academy 2018
School of Biological Sciences Teaching Load Coordinator 2012 - 2018
School of Biological Sciences Member of School Safety Committee 2008 - 2018
National Health and Medical Research Council (NHMRC) Grant Review Panel 2015 - 2017
Faculty of Science, Medicine and Health Member of the Faculty International Committee 2014 - 2016
Faculty of Science, Medicine and Health Member of Faculty Probations Committee 2010 - 2013

Education And Training

Ph.D. in Immunology, University of Sydney 1994 - 1999
B.A.S. in Biochemistry (Honours I), University of Technology, Sydney 1988 - 1991
Nepean Blue Mountains Local Health District, Department of Haematology 2000 - 2007
University of Sydney, Department of Pathology 1999

Credentials

Full Name

Ronald Sluyter

Mailing Address

Room 32.309, IHMRI (Bldg 32)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Illawarra

Orcid Id

http://orcid.org/0000-0003-4909-686X (confirmed)

Web Of Science Researcher Id

B-5798-2009

Scopus Id

7003993053

Top Publications

Year	Title
2017	The P2X7 Receptor
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published in Pharmacological Reviews
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published in Mediators of Inflammation

Research Areas

Research Overview

Ronald Sluyter is Head of the Immunology and Cell Signalling Group. His group explores the roles P2X7 and other purinergic signalling molecules in human and veterinary health and disease including graft-versus-host disease, cancer immunology, motor neurone disease and pain.

Head Of

Illawarra Health and Medical Research Institute Head of Immunology and Cell Signalling Group 2008 -

Member Of

Molecular Horizons Member 2018 -
The Australian and New Zealand Purine Club Co-President 2018 -
The Centre for Oncology Education and Research Translation (CONCERT) Member 2017 -
The Australian Physiological Society Member 2009 -
The Australian and New Zealand Society for Immunology Member 1993 -
Centre for Medical and Molecular Bioscience Member 2008 - 2018

Selected Publications

Journal Article

Year	Title
2020	Association of a P2RX7 gene missense variant with brachycephalic dog breeds Published In Animal Genetics Volume 51 Pages 127 - 131 ISSN 0268-9146 Altmetric
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published In Clinical science (London, England : 1979) Volume 134 Pages 207 - 223 Altmetric
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume Online First Pages 1 - 16 ISSN 1573-9546 Altmetric
2019	Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels Published In Microfluidics and Nanofluidics Volume 23 Pages 41-1 - 41-9 ISSN 1613-4982 Altmetric
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology Volume 54 Pages 38 - 46 ISSN 0966-3274 Altmetric
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology Volume 336 Pages 12 - 19 ISSN 0008-8749 Altmetric
2019	Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union Published In Critical Reviews in Toxicology Volume Online First Pages 1 - 18 ISSN 1040-8444 Altmetric
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology Volume Online First Pages 1 - 14 ISSN 0818-9641 Altmetric
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology Volume 72 Pages 479 - 486 ISSN 1567-5769 Altmetric
2018	A portable, hand-powered microfluidic device for sorting of biological particles Published In Microfluidics and Nanofluidics Volume 22 Pages 1 - 10 ISSN 1613-4982 Altmetric
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling Volume 14 Pages S57 - S58 ISSN 1573-9546 Altmetric
2017	Effects of Gold Nanoparticles and Gold Anti-Arthritic Compounds on Inflammation Marker Expression in Macrophages Published In Australian Journal of Chemistry: an international journal for chemical science Volume 70 Pages 1057 - 1068 ISSN 0004-9425 Altmetric
2017	High-Throughput Separation of White Blood Cells From Whole Blood Using Inertial Microfluidics Published In IEEE Transactions on Biomedical Circuits and Systems Volume 11 Pages 1422 - 1430 ISSN 1932-4545 Altmetric
2017	On-Chip Microparticle and Cell Washing Using Coflow of Viscoelastic Fluid and Newtonian Fluid Published In Analytical Chemistry Volume 89 Pages 9574 - 9582 ISSN 0003-2700 Altmetric
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ Volume 5 Pages e3064-1 - e3064-29 Altmetric
2017	P2X7 receptor antagonism in amyotrophic lateral sclerosis Published In Neural Regeneration Research Volume 12 Pages 749 - 750 Altmetric
2017	Probenecid directly impairs activation of the canine P2X7 receptor Published In Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication Volume 36 Pages 736 - 744 ISSN 1525-7770 Altmetric
2017	Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid Published In RSC Advances: an international journal to further the chemical sciences Volume 7 Pages 3461 - 3469 ISSN 2046-2069 Altmetric
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology Volume 190 Pages 79 - 95 ISSN 0009-9104 Altmetric
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling Volume 13 Pages 405 - 415 ISSN 1573-9546 Altmetric
2016	Continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays Published In Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering Volume 16 Pages 3919 - 3928 ISSN 1473-0197 Altmetric
2016	Editorial: Roles of ion channels in immune cells Published In Frontiers in Immunology Volume 7 Pages 48-1 - 48-2 ISSN 1664-3224 Altmetric
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation Volume 2016 Page p. 2097219 ISSN 0962-9351 Altmetric
2016	P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes Published In World Journal of Hematology Volume 5 Pages 88 - 93 Altmetric
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology Volume 5 Pages 72 - 83 Altmetric
2016	Roles of extracellular nucleotides and P2 receptors in ectodomain shedding Published In Cellular and Molecular Life Sciences Volume 73 Pages 4159 - 4173 ISSN 1420-682X Altmetric
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology Volume 93 Pages 77 - 85 ISSN 0818-9641 Altmetric
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry Volume 142 Pages 28 - 38 ISSN 0162-0134 Altmetric
2015	P2X and P2Y receptor signaling in red blood cells Published In Frontiers in Molecular Biosciences Volume 2 Pages 60-1 - 60-7 Altmetric
2015	Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging Published In Transfusion Volume 55 Pages 1946 - 1954 ISSN 1537-2995 Altmetric
2014	Extracellular adenosine 5'-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood Published In Veterinary Immunology and Immunopathology Volume 157 Pages 105 - 110 ISSN 0165-2427 Altmetric
2014	Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel Published In Scientific Reports Volume 4 Pages 1 - 9 ISSN 2045-2322 Altmetric
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology Volume 92 Pages A5 - A5 ISSN 0818-9641 Altmetric
2014	On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser Published In Scientific Reports Volume 4 Pages 1 - 8 ISSN 2045-2322 Altmetric
2014	P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells Published In Inflammation and Cell Signaling Volume 1 Pages 44 - 49 Altmetric
2014	Polymorphic variants of the P2X7 receptor in the domestic dog Published In Jacobs Journal of Veterinary Science and Research Volume 1 Page p. 008
2014	Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism Published In PLoS One Volume 9 Pages e93058-1 - e93058-8 ISSN 1932-6203 Altmetric
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published In Physiological Genomics Volume 46 Pages 512 - 522 ISSN 1094-8341 Altmetric
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research Volume 1 Pages 1 - 2
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published In Pharmacological Reviews Volume 66 Pages 638 - 675 ISSN 0031-6997 Altmetric
2013	CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation Published In Purinergic Signalling Volume 9 Pages 609 - 619 ISSN 1573-9546 Altmetric
2013	Human P2X7 receptor activation induces ADAM10-mediated shedding of CD23 and CXCL16 (P4137) Published In Journal of Immunology Volume 190 Pages 112.2 - 112.2 ISSN 0022-1767
2013	Human P2X7 receptor activation induces the rapid shedding of CXCL16 Published In Biochemical and Biophysical Research Communications Volume 432 Pages 626 - 631 ISSN 0006-291X Altmetric
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published In Mediators of Inflammation Volume 2013 Pages 271813-1 - 271813-18 ISSN 0962-9351 Altmetric
2013	P2X7 receptor activation induces reactive oxygen species formation in erythroid cells Published In Purinergic Signalling Volume 9 Pages 101 - 112 ISSN 1573-9546 Altmetric
2012	Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes Published In Veterinary Immunology and Immunopathology Volume 149 Pages 86 - 91 ISSN 0165-2427 Altmetric
2012	Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells Published In Veterinary Immunology and Immunopathology Volume 150 Pages 228 - 233 ISSN 0165-2427 Altmetric
2012	P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells Published In Purinergic Signalling Volume 8 Pages 669 - 676 ISSN 1573-9546 Altmetric
2011	Significance of P2X7 receptor variants to human health and disease Published In Recent Patents on DNA and Gene Sequences Volume 5 Pages 41 - 54 ISSN 1872-2156
2011	The human P2X7 receptor and its role in innate immunity Published In Tissue Antigens: immune response genetics Volume 78 Pages 321 - 332 ISSN 0001-2815 Altmetric
2010	Functional significance of P2RX7 polymorphisms associated with affective mood disorders Published In Journal of Psychiatric Research Volume 44 Pages 1116 - 1117 ISSN 0022-3956 Altmetric
2010	Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors Published In Experimental Dermatology Volume 19 Pages E151 - E157 ISSN 0906-6705 Altmetric
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects Volume 1800 Pages 1173 - 1182 ISSN 0304-4165 Altmetric
2010	P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells Published In BBA: Biomembranes Volume 1798 Pages 1797 - 1804 ISSN 0005-2736 Altmetric
2010	TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS inleukemic THP-1 monocytes Published In Biochimica et Biophysica Acta: international journal of biochemistry and biophysics Volume 1798 Pages 2058 - 2066 ISSN 0006-3002 Altmetric
2010	Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion Published In The FASEB Journal Volume 24 Pages 2916 - 2927 ISSN 0892-6638 Altmetric
2009	Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure Published In International Journal of Cardiology Volume 137 Pages 81 - 83 Altmetric
2009	The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types Published In Purinergic Signalling Volume 5 Pages 385 - 394 ISSN 1573-9546 Altmetric
2008	"Host tissue damage" signal ATP impairs IL-12 and IFNy secretion in LPS stimulated whole human blood Published In Intensive Care Medicine Volume 34 Pages 1891 - 1897 ISSN 0342-4642 Altmetric
2008	Comparison of the P2X7 receptor in canine and human erythrocytes and mononuclear leukocytes Published In Purinergic Signalling Volume 4 Pages S149 - S149 ISSN 1573-9546 Altmetric
2008	Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist Published In Biochemical and Biophysical Research Communications Volume 365 Pages 515 - 520 ISSN 0006-291X Altmetric
2007	A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis Published In American Journal of Respiratory and Critical Care Medicine Volume 175 Pages 360 - 366 ISSN 1073-449X Altmetric
2007	A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry Published In Journal of Immunological Methods Volume 325 Pages 67 - 77 ISSN 0022-1759 Altmetric
2007	Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes Published In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Volume 293 Pages R2090 - R2098 ISSN 0363-6119 Altmetric
2007	P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes Published In Biochemical and Biophysical Research Communications Volume 355 Pages 169 - 173 ISSN 0006-291X Altmetric
2007	Rottlerin inhibits P2X7 receptor-stimulated phospholipase D activity in chronic lumphocytic leukaemia B-lymphocytes Published In Immunology and Cell Biology Volume 85 Pages 68 - 72 ISSN 0818-9641 Altmetric

Chapter

Year	Title
2017	The P2X7 Receptor Published In Advances in Experimental Medicine and Biology: Protein Reviews Publisher Singapore: Springer Nature Pages 17 - 53 ISBN 9789811076107 Altmetric
2007	The genetic control of susceptibility to Mycobacterium tuberculosis Published In Decoding the Genomic Control of Immune Reactions Publisher John Wiley 7 Sons, Ltd Pages 79 - 89

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017 - 2018	Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Molecular mechanisms in coagulation and thrombotic events in dogs and cats Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Role of P2X Receptors in Chronic Pain Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: OAK Project Grant
2011	Microprobe XFM and XAS of gold anti-arthritic agents in macrophages Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	NALP3 inflammasome activation in canine health and disease Awarded by: Canine Research Foundation Funding Scheme: Research Grant
2010	Understanding mechanisms involved in canine autoimmune and inflammatory disorders Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: Research Grant
	Genetic variants of damage-associated molecular pattern receptor P2X7 in dogs: potential role in inflammatory and bone disorders, and in pain Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterisation of P2X4 and P2Y12 receptors in humans and companion animals	Sophocleous, Reece
Doctor of Philosophy	Mapping Programmed cell death of neutrophils in response to Group A Streptococcal infection	Williams, Jonathan
Doctor of Philosophy	Therapeutics Strategies to Prevent Graft-versus-Host Disease	Adhikary, Sam
Doctor of Philosophy	Next Generation Sunscreen Products Optimised for Australian Conditions	Morlando, Alexander
Doctor of Philosophy	Characterising the Interaction Between Group A Streptococcus and Hyaluronin	McEwan, Tahnee
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter
Doctor of Philosophy	Therapeutic Strategies to Prevent Graft-versus-Host Disease but Maintain Graft-versus-Tumour Immunity Following Allogeneic Stem Cell Transplantation	Bird, Katrina

Organizer Of Event

Professional Service Activities

School of Chemistry and Molecular Bioscience Safety Committee Member 2019 -
Australian and New Zealand Purine Club Co-President 2018 -
Faculty of Science, Medicine and Health Member of Faculty Research Committee 2015 -
Faculty of Science, Medicne and Health Chair of Safe@Work Committee 2008 -
National Health and Medical Research Council (NHMRC) Grant Review Panel 2019
National Health and Medical Research Council (NHMRC) Assigners Academy 2018
School of Biological Sciences Teaching Load Coordinator 2012 - 2018
School of Biological Sciences Member of School Safety Committee 2008 - 2018
National Health and Medical Research Council (NHMRC) Grant Review Panel 2015 - 2017
Faculty of Science, Medicine and Health Member of the Faculty International Committee 2014 - 2016
Faculty of Science, Medicine and Health Member of Faculty Probations Committee 2010 - 2013

Education And Training

Ph.D. in Immunology, University of Sydney 1994 - 1999
B.A.S. in Biochemistry (Honours I), University of Technology, Sydney 1988 - 1991
Nepean Blue Mountains Local Health District, Department of Haematology 2000 - 2007
University of Sydney, Department of Pathology 1999

Credentials

Full Name

Ronald Sluyter

Mailing Address

Room 32.309, IHMRI (Bldg 32)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Illawarra

Orcid Id

http://orcid.org/0000-0003-4909-686X (confirmed)

Web Of Science Researcher Id

B-5798-2009

Scopus Id

7003993053

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Service

Organizer Of Event

Professional Service Activities

Background

Education And Training

Credentials

Contact

Full Name

Mailing Address

Geographic Location

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Service

Organizer Of Event

Professional Service Activities

Background

Education And Training

Credentials

Contact

Full Name

Mailing Address

Geographic Location

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas