Sluyter, Ronald

Overview

Prof. Sluyter is an academic located in the School of Chemistry and Molecular Bioscience and group leader in the Illawarra Health and Medical Research Institute (IHMRI). Prof. Sluyter undertook Honours in 1991 (University of Technology, Sydney) investigating drug resistance in leukaemia before working for 2 years as a research assistant (University of Sydney) in cancer immunology and allergy, fueling his interest in cellular immunology. This resulted him in undertaking a PhD in cancer immunology (University of Sydney) and established his credentials as a cellular immunologist. He then worked as a research fellow studying West Nile viral infections (University of Sydney, 1999) and then P2X7 and purinergic signalling (Nepean Hospital, 2000-2007). During this second post-doctoral position, Prof. Sluyter discovered and characterised several mutations in the human P2RX7 gene and revealed their relevance to inflammation, leukaemia and tuberculosis. During this period he also discovered and characterised P2X7 on various blood and skin cells in humans and dogs. In 2008, Prof. Sluyter was appointed as a Senior Lecturer (University of Wollongong) where in addition to teaching biochemistry, immunology and cell biology, he continued to uncover the presence of P2X7 and other purinergic molecules on various cell types, and reveal the role of these molecules in human and companion animal health and disease including inflammation, graft-versus-host-disease, motor neurone disease, and head and neck cancer. He was promoted to Associate Professor in 2015 and full Professor in 2019, and continues to teach and undertake research in the above areas.

Top Publications

Year	Title
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published in Pharmacological Reviews
2017	The P2X7 Receptor
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published in Clinical and Experimental Immunology
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published in Immunology and Cell Biology
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published in Clinical Science
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published in PeerJ
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published in Mediators of Inflammation
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published in Immunology and Cell Biology
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published in Physiological Genomics

Research Areas

Research Overview

Prof. Sluyter is Head of the Immunology and Cell Signalling Group. His group explores the roles P2X7 and other purinergic signalling molecules in human and veterinary health and disease including graft-versus-host disease, cancer immunology, motor neurone disease and inflammation.

Geographic Focus

Illawarra Shoalhaven region Geographic Region

Head Of

Illawarra Health and Medical Research Institute Head of Immunology and Cell Signalling Group 2008 -

Member Of

Molecular Horizons Member 2018 -
The Australian and New Zealand Purine Club Treasurer 2018 -
The Australian and New Zealand Purine Club Co-President 2018 -
The Centre for Oncology Education and Research Translation (CONCERT) Member 2017 -
The Australian Physiological Society Member 2009 -
The Australian and New Zealand Society for Immunology Member 1993 -
Centre for Medical and Molecular Bioscience Member 2008 - 2018

Selected Publications

Journal Article

Year	Title
2020	A new class of quadruplex DNA-binding nickel Schiff base complexes Published In Dalton Transactions
2020	A single-nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanized mouse model Published In Immunology and Cell Biology
2020	Association of a P2RX7 gene missense variant with brachycephalic dog breeds Published In Animal Genetics
2020	Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73 Published In Purinergic Signalling
2020	Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line Published In Journal of Materials Chemistry B
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published In Clinical Science
2020	Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy Published In American Journal of Physiology - Cell Physiology
2020	P2y2 and p2x4 receptors mediate ca²⁺ mobilization in dh82 canine macrophage cells Published In International Journal of Molecular Sciences
2020	Pharmacological and genetic characterisation of the canine P2X4 receptor Published In British Journal of Pharmacology
2020	The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1^G93A mice Published In Purinergic Signalling
2020	Use of Humanized Mouse Models to Investigate the Roles of Purinergic Signaling in Inflammation and Immunity Published In Frontiers in Pharmacology
2020	Y2O3 decorated TiO2 nanoparticles: Enhanced UV attenuation and suppressed photocatalytic activity with promise for cosmetic and sunscreen applications Published In Journal of Photochemistry and Photobiology B: Biology
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling
2019	Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels Published In Microfluidics and Nanofluidics
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology
2019	Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union Published In Critical Reviews in Toxicology
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology
2018	A portable, hand-powered microfluidic device for sorting of biological particles Published In Microfluidics and Nanofluidics
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling
2017	Effects of Gold Nanoparticles and Gold Anti-Arthritic Compounds on Inflammation Marker Expression in Macrophages Published In Australian Journal of Chemistry: an international journal for chemical science
2017	High-Throughput Separation of White Blood Cells From Whole Blood Using Inertial Microfluidics Published In IEEE Transactions on Biomedical Circuits and Systems
2017	On-Chip Microparticle and Cell Washing Using Coflow of Viscoelastic Fluid and Newtonian Fluid Published In Analytical Chemistry
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ
2017	P2X7 receptor antagonism in amyotrophic lateral sclerosis Published In Neural Regeneration Research
2017	Probenecid directly impairs activation of the canine P2X7 receptor Published In Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
2017	Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid Published In RSC Advances: an international journal to further the chemical sciences
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling
2016	Continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays Published In Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
2016	Editorial: Roles of ion channels in immune cells Published In Frontiers in Immunology
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation
2016	P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes Published In World Journal of Hematology
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology
2016	Roles of extracellular nucleotides and P2 receptors in ectodomain shedding Published In Cellular and Molecular Life Sciences
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry
2015	P2X and P2Y receptor signaling in red blood cells Published In Frontiers in Molecular Biosciences
2015	Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging Published In Transfusion
2014	Extracellular adenosine 5'-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood Published In Veterinary Immunology and Immunopathology
2014	Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel Published In Scientific Reports
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology
2014	On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser Published In Scientific Reports
2014	P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells Published In Inflammation and Cell Signaling
2014	Polymorphic variants of the P2X7 receptor in the domestic dog Published In Jacobs Journal of Veterinary Science and Research
2014	Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism Published In PLoS One
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published In Physiological Genomics
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published In Pharmacological Reviews
2013	CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation Published In Purinergic Signalling
2013	Human P2X7 receptor activation induces ADAM10-mediated shedding of CD23 and CXCL16 (P4137) Published In Journal of Immunology
2013	Human P2X7 receptor activation induces the rapid shedding of CXCL16 Published In Biochemical and Biophysical Research Communications
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published In Mediators of Inflammation
2013	P2X7 receptor activation induces reactive oxygen species formation in erythroid cells Published In Purinergic Signalling
2012	Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes Published In Veterinary Immunology and Immunopathology
2012	Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells Published In Veterinary Immunology and Immunopathology
2012	P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells Published In Purinergic Signalling
2011	Significance of P2X7 receptor variants to human health and disease Published In Recent Patents on DNA and Gene Sequences
2011	The human P2X7 receptor and its role in innate immunity Published In Tissue Antigens: immune response genetics
2010	Functional significance of P2RX7 polymorphisms associated with affective mood disorders Published In Journal of Psychiatric Research
2010	Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors Published In Experimental Dermatology
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects
2010	P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells Published In BBA: Biomembranes
2010	TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS inleukemic THP-1 monocytes Published In Biochimica et Biophysica Acta: international journal of biochemistry and biophysics
2010	Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion Published In The FASEB Journal
2009	Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure Published In International Journal of Cardiology
2009	The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types Published In Purinergic Signalling
2008	"Host tissue damage" signal ATP impairs IL-12 and IFNy secretion in LPS stimulated whole human blood Published In Intensive Care Medicine
2008	Comparison of the P2X7 receptor in canine and human erythrocytes and mononuclear leukocytes Published In Purinergic Signalling
2008	Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist Published In Biochemical and Biophysical Research Communications
2007	A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis Published In American Journal of Respiratory and Critical Care Medicine
2007	A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry Published In Journal of Immunological Methods
2007	Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes Published In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
2007	P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes Published In Biochemical and Biophysical Research Communications
2007	Rottlerin inhibits P2X7 receptor-stimulated phospholipase D activity in chronic lumphocytic leukaemia B-lymphocytes Published In Immunology and Cell Biology

Chapter

Year	Title
2017	The P2X7 Receptor Published In Advances in Experimental Medicine and Biology: Protein Reviews Publisher Singapore
2007	The genetic control of susceptibility to Mycobacterium tuberculosis Published In Decoding the Genomic Control of Immune Reactions

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017 - 2018	Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Molecular mechanisms in coagulation and thrombotic events in dogs and cats Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Role of P2X Receptors in Chronic Pain Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: OAK Project Grant
2011	Microprobe XFM and XAS of gold anti-arthritic agents in macrophages Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	NALP3 inflammasome activation in canine health and disease Awarded by: Canine Research Foundation Funding Scheme: Research Grant
2010	Understanding mechanisms involved in canine autoimmune and inflammatory disorders Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: Research Grant
	Genetic variants of damage-associated molecular pattern receptor P2X7 in dogs: potential role in inflammatory and bone disorders, and in pain Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant

Impact Story

Teaching Activities

SCIP200 Chemistry and Molecular Bioscience Studies Coordinator 2020 -
BIOL342 Biomedical Research Skills and Techniques Instructor 2019 -
BIOL341 Immunity and Infection Instructor 2018 -
BIOL214 Biochemistry of Energy and Metabolism Coordinator 2008 -
BIOL321 Infection and Immunity Instructor 2008 - 2017
BIOL213 Principles of Biochemistry Instructor 2015
BIOL320 Molecular and Cell Biology Instructor 2008 - 2009
BIOL421 Professional Skills in Biotechnology Instructor 2008

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterising the neutrophil response to Group A Streptococcus	Williams, Jonathan
Doctor of Philosophy	Investigating the role of host and pathogen factors in group A streptococcal skin infection	McEwan, Tahnee
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter
Doctor of Philosophy	New generation multifunctional nanoceramics for melanoma prevention and therapy	Chaki Borras, Marcela
Doctor of Philosophy	Investigations of the Anti-cancer Potential of Bi and Ga Complexes of Nonsteroidal Anti-inflammatory Drugs and Flavonoids.	Crapis, Serafina
Doctor of Philosophy	Combination Therapies to Prevent Graft-versus-host Disease.	Sligar, Chloe
Doctor of Philosophy	Targeting P2X7 to Prevent Graft-versus-Host Disease Following Donor Stem Cell Transplantation	El Hage, Amal

Organizer Of Event

Professional Service Activities

School of Chemistry and Molecular Bioscience HDR Coordinator 2020 -
University of Wollongong Level E Promotion Mentor 2020 -
School of Chemistry and Molecular Bioscience Teaching Load Coordinator 2019 -
School of Chemistry and Molecular Bioscience Safety Committee Member 2019 -
Australian and New Zealand Purine Club Co-President 2018 -
University of Wollongong Accredited Peer Reviewer of Teaching 2018 -
Faculty of Science, Medicine and Health Member of Faculty Research Committee 2015 -
Faculty of Science, Medicne and Health Chair of Safe@Work Committee 2008 -
National Health and Medical Research Council (NHMRC) Grant Review Panel 2019
National Health and Medical Research Council (NHMRC) Assigners Academy 2018
School of Biological Sciences Teaching Load Coordinator 2012 - 2018
School of Biological Sciences Member of School Safety Committee 2008 - 2018
National Health and Medical Research Council (NHMRC) Grant Review Panel 2015 - 2017
Faculty of Science, Medicine and Health Member of the Faculty International Committee 2014 - 2016
Faculty of Science, Medicine and Health Member of Faculty Probations Committee 2010 - 2013

Education And Training

Ph.D. in Immunology, University of Sydney 1994 - 1999
B.A.S. in Biochemistry (Honours I), University of Technology, Sydney 1988 - 1991
Nepean Blue Mountains Local Health District, Department of Haematology 2000 - 2007
University of Sydney, Department of Pathology 1999

Credentials

Keywords

Blood cancers
Cellular immunology
Flow cytometry
Graft-versus-host disease
Motor neurone disease
Purinergic signalling
Skin and mucosal cancers

Full Name

Ronald Sluyter

Mailing Address

Room 32.306, IHMRI (Bldg 32)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Illawarra

Orcid Id

http://orcid.org/0000-0003-4909-686X (confirmed)

Web Of Science Researcher Id

B-5798-2009

Scopus Id

7003993053

Top Publications

Year	Title
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published in Pharmacological Reviews
2017	The P2X7 Receptor
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published in Clinical and Experimental Immunology
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published in Immunology and Cell Biology
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published in Clinical Science
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published in PeerJ
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published in Mediators of Inflammation
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published in Immunology and Cell Biology
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published in Physiological Genomics

Research Areas

Research Overview

Prof. Sluyter is Head of the Immunology and Cell Signalling Group. His group explores the roles P2X7 and other purinergic signalling molecules in human and veterinary health and disease including graft-versus-host disease, cancer immunology, motor neurone disease and inflammation.

Geographic Focus

Illawarra Shoalhaven region Geographic Region

Head Of

Illawarra Health and Medical Research Institute Head of Immunology and Cell Signalling Group 2008 -

Member Of

Molecular Horizons Member 2018 -
The Australian and New Zealand Purine Club Treasurer 2018 -
The Australian and New Zealand Purine Club Co-President 2018 -
The Centre for Oncology Education and Research Translation (CONCERT) Member 2017 -
The Australian Physiological Society Member 2009 -
The Australian and New Zealand Society for Immunology Member 1993 -
Centre for Medical and Molecular Bioscience Member 2008 - 2018

Selected Publications

Journal Article

Year	Title
2020	A new class of quadruplex DNA-binding nickel Schiff base complexes Published In Dalton Transactions
2020	A single-nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanized mouse model Published In Immunology and Cell Biology
2020	Association of a P2RX7 gene missense variant with brachycephalic dog breeds Published In Animal Genetics
2020	Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73 Published In Purinergic Signalling
2020	Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line Published In Journal of Materials Chemistry B
2020	Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease Published In Clinical Science
2020	Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy Published In American Journal of Physiology - Cell Physiology
2020	P2y2 and p2x4 receptors mediate ca²⁺ mobilization in dh82 canine macrophage cells Published In International Journal of Molecular Sciences
2020	Pharmacological and genetic characterisation of the canine P2X4 receptor Published In British Journal of Pharmacology
2020	The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1^G93A mice Published In Purinergic Signalling
2020	Use of Humanized Mouse Models to Investigate the Roles of Purinergic Signaling in Inflammation and Immunity Published In Frontiers in Pharmacology
2020	Y2O3 decorated TiO2 nanoparticles: Enhanced UV attenuation and suppressed photocatalytic activity with promise for cosmetic and sunscreen applications Published In Journal of Photochemistry and Photobiology B: Biology
2019	Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice Published In Purinergic Signalling
2019	Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels Published In Microfluidics and Nanofluidics
2019	Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice Published In Transplant Immunology
2019	Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease Published In Cellular Immunology
2019	Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union Published In Critical Reviews in Toxicology
2019	Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease Published In Immunology and Cell Biology
2019	The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease Published In International Immunopharmacology
2018	A portable, hand-powered microfluidic device for sorting of biological particles Published In Microfluidics and Nanofluidics
2018	Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice Published In Purinergic Signalling
2017	Effects of Gold Nanoparticles and Gold Anti-Arthritic Compounds on Inflammation Marker Expression in Macrophages Published In Australian Journal of Chemistry: an international journal for chemical science
2017	High-Throughput Separation of White Blood Cells From Whole Blood Using Inertial Microfluidics Published In IEEE Transactions on Biomedical Circuits and Systems
2017	On-Chip Microparticle and Cell Washing Using Coflow of Viscoelastic Fluid and Newtonian Fluid Published In Analytical Chemistry
2017	P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice Published In PeerJ
2017	P2X7 receptor antagonism in amyotrophic lateral sclerosis Published In Neural Regeneration Research
2017	Probenecid directly impairs activation of the canine P2X7 receptor Published In Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
2017	Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid Published In RSC Advances: an international journal to further the chemical sciences
2017	The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease Published In Clinical and Experimental Immunology
2017	The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice Published In Purinergic Signalling
2016	Continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays Published In Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
2016	Editorial: Roles of ion channels in immune cells Published In Frontiers in Immunology
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation
2016	P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes Published In World Journal of Hematology
2016	P2X7 receptor in skin biology and diseases Published In World Journal of Dermatology
2016	Roles of extracellular nucleotides and P2 receptors in ectodomain shedding Published In Cellular and Molecular Life Sciences
2015	Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells Published In Immunology and Cell Biology
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry
2015	P2X and P2Y receptor signaling in red blood cells Published In Frontiers in Molecular Biosciences
2015	Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging Published In Transfusion
2014	Extracellular adenosine 5'-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood Published In Veterinary Immunology and Immunopathology
2014	Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel Published In Scientific Reports
2014	Investigating the effects of purinergic receptor (P2X7R) blockade on the development of graft-versus-host-disease (gvhd) in humanised mice Published In Immunology and Cell Biology
2014	On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser Published In Scientific Reports
2014	P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells Published In Inflammation and Cell Signaling
2014	Polymorphic variants of the P2X7 receptor in the domestic dog Published In Jacobs Journal of Veterinary Science and Research
2014	Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism Published In PLoS One
2014	R270C polymorphism leads to loss of function of the canine P2X7 receptor Published In Physiological Genomics
2014	T Cells continue to play on the ATP circuit Published In Journal of Immune Research
2014	The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease Published In Pharmacological Reviews
2013	CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation Published In Purinergic Signalling
2013	Human P2X7 receptor activation induces ADAM10-mediated shedding of CD23 and CXCL16 (P4137) Published In Journal of Immunology
2013	Human P2X7 receptor activation induces the rapid shedding of CXCL16 Published In Biochemical and Biophysical Research Communications
2013	P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia Published In Mediators of Inflammation
2013	P2X7 receptor activation induces reactive oxygen species formation in erythroid cells Published In Purinergic Signalling
2012	Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes Published In Veterinary Immunology and Immunopathology
2012	Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells Published In Veterinary Immunology and Immunopathology
2012	P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells Published In Purinergic Signalling
2011	Significance of P2X7 receptor variants to human health and disease Published In Recent Patents on DNA and Gene Sequences
2011	The human P2X7 receptor and its role in innate immunity Published In Tissue Antigens: immune response genetics
2010	Functional significance of P2RX7 polymorphisms associated with affective mood disorders Published In Journal of Psychiatric Research
2010	Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors Published In Experimental Dermatology
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects
2010	P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells Published In BBA: Biomembranes
2010	TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS inleukemic THP-1 monocytes Published In Biochimica et Biophysica Acta: international journal of biochemistry and biophysics
2010	Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion Published In The FASEB Journal
2009	Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure Published In International Journal of Cardiology
2009	The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types Published In Purinergic Signalling
2008	"Host tissue damage" signal ATP impairs IL-12 and IFNy secretion in LPS stimulated whole human blood Published In Intensive Care Medicine
2008	Comparison of the P2X7 receptor in canine and human erythrocytes and mononuclear leukocytes Published In Purinergic Signalling
2008	Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist Published In Biochemical and Biophysical Research Communications
2007	A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis Published In American Journal of Respiratory and Critical Care Medicine
2007	A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry Published In Journal of Immunological Methods
2007	Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes Published In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
2007	P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes Published In Biochemical and Biophysical Research Communications
2007	Rottlerin inhibits P2X7 receptor-stimulated phospholipase D activity in chronic lumphocytic leukaemia B-lymphocytes Published In Immunology and Cell Biology

Chapter

Year	Title
2017	The P2X7 Receptor Published In Advances in Experimental Medicine and Biology: Protein Reviews Publisher Singapore
2007	The genetic control of susceptibility to Mycobacterium tuberculosis Published In Decoding the Genomic Control of Immune Reactions

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2017 - 2018	Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Molecular mechanisms in coagulation and thrombotic events in dogs and cats Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Role of P2X Receptors in Chronic Pain Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: OAK Project Grant
2011	Microprobe XFM and XAS of gold anti-arthritic agents in macrophages Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	NALP3 inflammasome activation in canine health and disease Awarded by: Canine Research Foundation Funding Scheme: Research Grant
2010	Understanding mechanisms involved in canine autoimmune and inflammatory disorders Awarded by: American Kennel Club Canine Health Foundation Funding Scheme: Research Grant
	Genetic variants of damage-associated molecular pattern receptor P2X7 in dogs: potential role in inflammatory and bone disorders, and in pain Awarded by: Australian Companion Animal Health Foundation Funding Scheme: Grant

Impact Story

Teaching Activities

SCIP200 Chemistry and Molecular Bioscience Studies Coordinator 2020 -
BIOL342 Biomedical Research Skills and Techniques Instructor 2019 -
BIOL341 Immunity and Infection Instructor 2018 -
BIOL214 Biochemistry of Energy and Metabolism Coordinator 2008 -
BIOL321 Infection and Immunity Instructor 2008 - 2017
BIOL213 Principles of Biochemistry Instructor 2015
BIOL320 Molecular and Cell Biology Instructor 2008 - 2009
BIOL421 Professional Skills in Biotechnology Instructor 2008

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterising the neutrophil response to Group A Streptococcus	Williams, Jonathan
Doctor of Philosophy	Investigating the role of host and pathogen factors in group A streptococcal skin infection	McEwan, Tahnee
Doctor of Philosophy	The P2X7 Receptor in Inflammation and Disease	Cuthbertson, Peter
Doctor of Philosophy	New generation multifunctional nanoceramics for melanoma prevention and therapy	Chaki Borras, Marcela
Doctor of Philosophy	Investigations of the Anti-cancer Potential of Bi and Ga Complexes of Nonsteroidal Anti-inflammatory Drugs and Flavonoids.	Crapis, Serafina
Doctor of Philosophy	Combination Therapies to Prevent Graft-versus-host Disease.	Sligar, Chloe
Doctor of Philosophy	Targeting P2X7 to Prevent Graft-versus-Host Disease Following Donor Stem Cell Transplantation	El Hage, Amal

Organizer Of Event

Professional Service Activities

School of Chemistry and Molecular Bioscience HDR Coordinator 2020 -
University of Wollongong Level E Promotion Mentor 2020 -
School of Chemistry and Molecular Bioscience Teaching Load Coordinator 2019 -
School of Chemistry and Molecular Bioscience Safety Committee Member 2019 -
Australian and New Zealand Purine Club Co-President 2018 -
University of Wollongong Accredited Peer Reviewer of Teaching 2018 -
Faculty of Science, Medicine and Health Member of Faculty Research Committee 2015 -
Faculty of Science, Medicne and Health Chair of Safe@Work Committee 2008 -
National Health and Medical Research Council (NHMRC) Grant Review Panel 2019
National Health and Medical Research Council (NHMRC) Assigners Academy 2018
School of Biological Sciences Teaching Load Coordinator 2012 - 2018
School of Biological Sciences Member of School Safety Committee 2008 - 2018
National Health and Medical Research Council (NHMRC) Grant Review Panel 2015 - 2017
Faculty of Science, Medicine and Health Member of the Faculty International Committee 2014 - 2016
Faculty of Science, Medicine and Health Member of Faculty Probations Committee 2010 - 2013

Education And Training

Ph.D. in Immunology, University of Sydney 1994 - 1999
B.A.S. in Biochemistry (Honours I), University of Technology, Sydney 1988 - 1991
Nepean Blue Mountains Local Health District, Department of Haematology 2000 - 2007
University of Sydney, Department of Pathology 1999

Credentials

Keywords

Blood cancers
Cellular immunology
Flow cytometry
Graft-versus-host disease
Motor neurone disease
Purinergic signalling
Skin and mucosal cancers

Full Name

Ronald Sluyter

Mailing Address

Room 32.306, IHMRI (Bldg 32)

University of Wollongong

Wollongong

NSW

2522

Australia

Geographic Location

Illawarra

Orcid Id

http://orcid.org/0000-0003-4909-686X (confirmed)

Web Of Science Researcher Id

B-5798-2009

Scopus Id

7003993053

Overview

Overview

Top Publications

Research Areas

Research Overview

Geographic Focus

Affiliation

Head Of

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Impact

Impact Story

Supervision

Teaching Activities

Advisees

Graduate Advising Relationship

Service

Organizer Of Event

Professional Service Activities

Background

Education And Training

Credentials

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Top Publications

Research Areas

Research Overview

Geographic Focus

Affiliation

Head Of

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Impact

Impact Story

Supervision

Teaching Activities

Advisees

Graduate Advising Relationship

Service

Organizer Of Event

Professional Service Activities

Background

Education And Training

Credentials

Keywords

Contact

Full Name

Mailing Address

Geographic Location

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas

Geographic Focus