In order to obtain good strength���plasticity synergy for a medium entropy alloy (MEA) CrCoNi, cold rolling, asymmetric rolling, cryorolling and asymmetric-cryorolling with subsequent annealing at different temperatures were conducted. The results showed that the asymmetric-cryorolled alloy achieved a high strength of over 1.6 GPa. After annealing at 1073 K, it retained a high strength of ~1 GPa while the elongation reached nearly 60%. After annealing, the heterogeneous characteristics were formed in asymmetric-cryorolled samples, which were found to be more distinct than those of the samples subjected to asymmetric rolling. This resulted in the generation of high strength and ductility.