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Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.

Journal Article


Abstract


  • Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.

Publication Date


  • 1994

Citation


  • Narayanan, M. N., Morgenstern, G. R., Chang, J. C., Harrison, C. J., Ranson, M., & Scarffe, J. H. (1994). Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.. British journal of haematology, 86(4), 867-869. doi:10.1111/j.1365-2141.1994.tb04844.x

Web Of Science Accession Number


Start Page


  • 867

End Page


  • 869

Volume


  • 86

Issue


  • 4

Abstract


  • Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.

Publication Date


  • 1994

Citation


  • Narayanan, M. N., Morgenstern, G. R., Chang, J. C., Harrison, C. J., Ranson, M., & Scarffe, J. H. (1994). Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.. British journal of haematology, 86(4), 867-869. doi:10.1111/j.1365-2141.1994.tb04844.x

Web Of Science Accession Number


Start Page


  • 867

End Page


  • 869

Volume


  • 86

Issue


  • 4