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VAD chemotherapy as remission induction for multiple myeloma.

Journal Article


Abstract


  • A total of 142 patients with multiple myeloma received VAD as remission induction therapy. Seventy-five were previously untreated and 67 had relapsed (31) or refractory disease (36). Vincristine (total dose 1.6 mg) was infused with doxorubicin 36 mg m-2 by continuous ambulatory pump over 4 days. In addition, oral dexamethasone 40 mg day-1 was given for 4 days. Intermittent dexamethasone was only given to 19 patients. Courses were repeated every 21 days. The overall response rate was 84% [27% complete response (CR)] in previously untreated patients and 61% (3% CR) in patients with relapsed and refractory disease. The median survival was 36 months for untreated patients and 10 months for those who had received prior therapy. VAD was well tolerated; however, despite prophylaxis, 54% patients received antibiotics at some time during therapy and 37% had dyspepsia. Twenty-three patients subsequently received a transplant (eight allografts, eight marrow autografts and seven peripheral blood stem cell transplants). Eight have died-four in the allogeneic group and four in the autologous group. The overall median survival of transplanted patients has not yet been reached. VAD is an effective, out-patient therapy for inducing remission in multiple myeloma. Post-remission therapy needs to be optimised, but it is likely that the needs of previously untreated patients may be different from those with relapsed and refractory disease.

UOW Authors


  •   Ranson, Marie (external author)

Publication Date


  • 1995

Citation


  • Anderson, H., Scarffe, J. H., Ranson, M., Young, R., Wieringa, G. S., Morgenstern, G. R., . . . Ryder, D. (1995). VAD chemotherapy as remission induction for multiple myeloma.. British journal of cancer, 71(2), 326-330. doi:10.1038/bjc.1995.65

Web Of Science Accession Number


Start Page


  • 326

End Page


  • 330

Volume


  • 71

Issue


  • 2

Abstract


  • A total of 142 patients with multiple myeloma received VAD as remission induction therapy. Seventy-five were previously untreated and 67 had relapsed (31) or refractory disease (36). Vincristine (total dose 1.6 mg) was infused with doxorubicin 36 mg m-2 by continuous ambulatory pump over 4 days. In addition, oral dexamethasone 40 mg day-1 was given for 4 days. Intermittent dexamethasone was only given to 19 patients. Courses were repeated every 21 days. The overall response rate was 84% [27% complete response (CR)] in previously untreated patients and 61% (3% CR) in patients with relapsed and refractory disease. The median survival was 36 months for untreated patients and 10 months for those who had received prior therapy. VAD was well tolerated; however, despite prophylaxis, 54% patients received antibiotics at some time during therapy and 37% had dyspepsia. Twenty-three patients subsequently received a transplant (eight allografts, eight marrow autografts and seven peripheral blood stem cell transplants). Eight have died-four in the allogeneic group and four in the autologous group. The overall median survival of transplanted patients has not yet been reached. VAD is an effective, out-patient therapy for inducing remission in multiple myeloma. Post-remission therapy needs to be optimised, but it is likely that the needs of previously untreated patients may be different from those with relapsed and refractory disease.

UOW Authors


  •   Ranson, Marie (external author)

Publication Date


  • 1995

Citation


  • Anderson, H., Scarffe, J. H., Ranson, M., Young, R., Wieringa, G. S., Morgenstern, G. R., . . . Ryder, D. (1995). VAD chemotherapy as remission induction for multiple myeloma.. British journal of cancer, 71(2), 326-330. doi:10.1038/bjc.1995.65

Web Of Science Accession Number


Start Page


  • 326

End Page


  • 330

Volume


  • 71

Issue


  • 2