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A controlled trial of adjuvant tamoxifen, with or without prednisolone, in post-menopausal women with operable breast cancer.

Journal Article


Abstract


  • A randomised clinical trial has been conducted to compare adjuvant tamoxifen, 20 mg daily, with tamoxifen and prednisolone, 7.5 mg daily, in post-menopausal women with operable breast cancer. There were 254 evaluable patients, of whom 128 were given tamoxifen alone and 126 received tamoxifen and prednisolone. After a median follow-up of 48 months there was no significant difference in relapse-free or overall survival of the two groups. Furthermore, with survival slightly favouring tamoxifen, confidence intervals on the hazard ratio established that a difference in favour of tamoxifen plus prednisolone of even 5% at 5 years was very unlikely (P < 0.02). Thus, despite the relatively small number of patients in this trial, the data clearly establish that prednisolone is not of value as an additional adjuvant agent.

Publication Date


  • 1994

Citation


  • Fentiman, I. S., Howell, A., Hamed, H., Lee, S. M., Ranson, M., Wall, J., . . . Sellwood, R. A. (1994). A controlled trial of adjuvant tamoxifen, with or without prednisolone, in post-menopausal women with operable breast cancer.. British journal of cancer, 70(4), 729-731. doi:10.1038/bjc.1994.384

Web Of Science Accession Number


Start Page


  • 729

End Page


  • 731

Volume


  • 70

Issue


  • 4

Abstract


  • A randomised clinical trial has been conducted to compare adjuvant tamoxifen, 20 mg daily, with tamoxifen and prednisolone, 7.5 mg daily, in post-menopausal women with operable breast cancer. There were 254 evaluable patients, of whom 128 were given tamoxifen alone and 126 received tamoxifen and prednisolone. After a median follow-up of 48 months there was no significant difference in relapse-free or overall survival of the two groups. Furthermore, with survival slightly favouring tamoxifen, confidence intervals on the hazard ratio established that a difference in favour of tamoxifen plus prednisolone of even 5% at 5 years was very unlikely (P < 0.02). Thus, despite the relatively small number of patients in this trial, the data clearly establish that prednisolone is not of value as an additional adjuvant agent.

Publication Date


  • 1994

Citation


  • Fentiman, I. S., Howell, A., Hamed, H., Lee, S. M., Ranson, M., Wall, J., . . . Sellwood, R. A. (1994). A controlled trial of adjuvant tamoxifen, with or without prednisolone, in post-menopausal women with operable breast cancer.. British journal of cancer, 70(4), 729-731. doi:10.1038/bjc.1994.384

Web Of Science Accession Number


Start Page


  • 729

End Page


  • 731

Volume


  • 70

Issue


  • 4