A novel and unexpected one pot synthesis of pyrrolo[1,2-a]quinolines

Citation

• Sansom, G. N., Semken, J., Kelso, M. J., & Richardson, C. (2022). A novel and unexpected one pot synthesis of pyrrolo[1,2-a]quinolines. Tetrahedron Letters. doi:10.1016/j.tetlet.2022.153794

Digital Object Identifier (doi)

• 10.1016/j.tetlet.2022.153794

Scopus Eid

• 2-s2.0-85130012431

Web Of Science Accession Number

Abstract

• A new low temperature route to pyrrolo[1,2-a]quinolines bearing ester groups in the 5-position is reported. The reaction mechanism was found to depend on the reaction temperature. At low temperatures it is proposed the reaction proceeds though an addition-intramolecular SNAr-elimination pathway. This method should find wider use as it avoids high boiling point solvents and affords compatibility with thermosensitive substrates.

UOW Authors

•   Kelso, Michael
•   Richardson, Christopher

Publication Date

• 2022

Publisher

• Elsevier BV 

Published In

• Tetrahedron Letters  Journal

Citation

• Sansom, G. N., Semken, J., Kelso, M. J., & Richardson, C. (2022). A novel and unexpected one pot synthesis of pyrrolo[1,2-a]quinolines. Tetrahedron Letters. doi:10.1016/j.tetlet.2022.153794

Digital Object Identifier (doi)

• 10.1016/j.tetlet.2022.153794

Scopus Eid

• 2-s2.0-85130012431

Web Of Science Accession Number