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Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Journal Article


Abstract


  • Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26���0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (���0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

UOW Authors


  •   Hardcastle, Nicholas (external author)

Publication Date


  • 2022

Citation


  • Li, Z., Le Roux, P. Y., Callahan, J., Hardcastle, N., Hofman, M. S., Siva, S., & Yamamoto, T. (2022). Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients. Physics and Imaging in Radiation Oncology, 22, 8-12. doi:10.1016/j.phro.2022.03.005

Scopus Eid


  • 2-s2.0-85127850006

Web Of Science Accession Number


Start Page


  • 8

End Page


  • 12

Volume


  • 22

Issue


Place Of Publication


Abstract


  • Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 (68Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (DLCO). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26���0.88). 68Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with DLCO (���0.59). Our findings suggested that 68Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

UOW Authors


  •   Hardcastle, Nicholas (external author)

Publication Date


  • 2022

Citation


  • Li, Z., Le Roux, P. Y., Callahan, J., Hardcastle, N., Hofman, M. S., Siva, S., & Yamamoto, T. (2022). Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients. Physics and Imaging in Radiation Oncology, 22, 8-12. doi:10.1016/j.phro.2022.03.005

Scopus Eid


  • 2-s2.0-85127850006

Web Of Science Accession Number


Start Page


  • 8

End Page


  • 12

Volume


  • 22

Issue


Place Of Publication