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Consensus-based standards for best supportive care in clinical trials in advanced cancer

Journal Article


Abstract


  • Best supportive care is poorly defined in clinical trials, and a standard framework for delivery of such care is needed, using best available evidence and allowing replication of studies. We convened a panel of 36 experts to develop consensus statements via the Delphi method. The first round included open-ended questions; subsequent rounds sought to develop consensus-based standards. Consensus was assessed by use of a 5-point Likert agreement scale; more than 70% of panellists had to give a score of 5 to meet a-priori levels of consensus. The panel identified four key domains of best supportive care in clinical trials: multidisciplinary care; supportive care documentation; symptom assessment; and symptom management. Consensus was reached on 11 statements within these four domains. For example, 24 (96%) panellists recommended that the intervals between symptom assessments should be identical for control and experimental groups. Availability of resources was cited as a challenge to implementation of best supportive care standards. �� 2012 Elsevier Ltd.

Publication Date


  • 2012

Citation


  • Zafar, S. Y., Currow, D. C., Cherny, N., Strasser, F., Fowler, R., & Abernethy, A. P. (2012). Consensus-based standards for best supportive care in clinical trials in advanced cancer. The Lancet Oncology, 13(2). doi:10.1016/S1470-2045(11)70215-7

Scopus Eid


  • 2-s2.0-84856438424

Volume


  • 13

Issue


  • 2

Place Of Publication


Abstract


  • Best supportive care is poorly defined in clinical trials, and a standard framework for delivery of such care is needed, using best available evidence and allowing replication of studies. We convened a panel of 36 experts to develop consensus statements via the Delphi method. The first round included open-ended questions; subsequent rounds sought to develop consensus-based standards. Consensus was assessed by use of a 5-point Likert agreement scale; more than 70% of panellists had to give a score of 5 to meet a-priori levels of consensus. The panel identified four key domains of best supportive care in clinical trials: multidisciplinary care; supportive care documentation; symptom assessment; and symptom management. Consensus was reached on 11 statements within these four domains. For example, 24 (96%) panellists recommended that the intervals between symptom assessments should be identical for control and experimental groups. Availability of resources was cited as a challenge to implementation of best supportive care standards. �� 2012 Elsevier Ltd.

Publication Date


  • 2012

Citation


  • Zafar, S. Y., Currow, D. C., Cherny, N., Strasser, F., Fowler, R., & Abernethy, A. P. (2012). Consensus-based standards for best supportive care in clinical trials in advanced cancer. The Lancet Oncology, 13(2). doi:10.1016/S1470-2045(11)70215-7

Scopus Eid


  • 2-s2.0-84856438424

Volume


  • 13

Issue


  • 2

Place Of Publication