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A Dyadic Growth Modeling Approach for Examining Associations between Weight Gain and Lung Function Decline

Journal Article


Abstract


  • The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ���3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year,-25.50 mL/year,-21.99 mL/year, and-0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r =-0.16) and FVC (r =-0.26) and slower declines in FEV1:FVC ratio (r = 0.11) (all P values < 0.0001). Results were similar in subgroup analyses. Residual correlations were negative (P < 0.0001), suggesting additional interdependence between BMI and lung function. Results show that greater rates of weight gain are associated with greater rates of lung function loss.

Publication Date


  • 2020

Citation


  • Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., . . . Oelsner, E. C. (2020). A Dyadic Growth Modeling Approach for Examining Associations between Weight Gain and Lung Function Decline. American Journal of Epidemiology, 189(10), 1173-1184. doi:10.1093/aje/kwaa059

Scopus Eid


  • 2-s2.0-85092679961

Start Page


  • 1173

End Page


  • 1184

Volume


  • 189

Issue


  • 10

Place Of Publication


Abstract


  • The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ���3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year,-25.50 mL/year,-21.99 mL/year, and-0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r =-0.16) and FVC (r =-0.26) and slower declines in FEV1:FVC ratio (r = 0.11) (all P values < 0.0001). Results were similar in subgroup analyses. Residual correlations were negative (P < 0.0001), suggesting additional interdependence between BMI and lung function. Results show that greater rates of weight gain are associated with greater rates of lung function loss.

Publication Date


  • 2020

Citation


  • Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., . . . Oelsner, E. C. (2020). A Dyadic Growth Modeling Approach for Examining Associations between Weight Gain and Lung Function Decline. American Journal of Epidemiology, 189(10), 1173-1184. doi:10.1093/aje/kwaa059

Scopus Eid


  • 2-s2.0-85092679961

Start Page


  • 1173

End Page


  • 1184

Volume


  • 189

Issue


  • 10

Place Of Publication