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Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease a systematic review

Journal Article


Abstract


  • Rationale: Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from breathlessness, deconditioning, and reduced health-related quality of life (HRQL) despite best medical management. Opioids may relieve breathlessness at rest and on exertion in COPD. Objectives: We aimed to estimate the efficacy and safety of opioids on refractory breathlessness, exercise capacity, and HRQL in COPD. Methods: This was a systematic review and metaanalysis using Cochrane methodology. We searched Cochrane Central Register of Controlled Trials, MEDLINE, and Embase up to 8 September, 2014 for randomized, double-blind, placebo-controlled trials of any opioid for breathlessness, exercise capacity, or HRQL that included at least one participant with COPD. Effects were analyzed as standardized mean differences (SMDs) with 95% confidence intervals (CIs) using random effect models. Measurements and Main Results: A total of 16 studies (15 crossover trials and 1 parallel-group study, 271 participants, 95% with severe COPD) were included. There were no serious adverse effects. Breathlessness was reduced by opioids overall: SMD, 20.35 (95% CI, 20.53 to 20.17; I2, 48.9%), by systemic opioids (eight studies, 118 participants): SMD, 20.34 (95% CI, 20.58 to 20.10; I2, 0%), and less consistently by nebulized opioids (four studies, 82 participants): SMD, 20.39 (95% CI, 20.71 to 20.07; I2, 78.9%). The quality of evidence was moderate for systemic opioids and low for nebulized opioids on breathlessness.Opioids did not affect exercise capacity (13 studies, 149 participants): SMD, 0.06 (95% CI, 20.15 to 0.28; I2, 70.7%). HRQL couldnot be analyzed. Findingswere robust in sensitivity analyses.Risk of study bias was low or unclear. Conclusions: Opioids improved breathlessness but not exercise capacity in severe COPD.

Publication Date


  • 2015

Citation


  • Ekstr��m, M., Nilsson, F., Abernethy, A. A., & Currow, D. C. (2015). Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease a systematic review. Annals of the American Thoracic Society, 12(7), 1079-1092. doi:10.1513/AnnalsATS.201501-034OC

Scopus Eid


  • 2-s2.0-84942246802

Start Page


  • 1079

End Page


  • 1092

Volume


  • 12

Issue


  • 7

Place Of Publication


Abstract


  • Rationale: Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from breathlessness, deconditioning, and reduced health-related quality of life (HRQL) despite best medical management. Opioids may relieve breathlessness at rest and on exertion in COPD. Objectives: We aimed to estimate the efficacy and safety of opioids on refractory breathlessness, exercise capacity, and HRQL in COPD. Methods: This was a systematic review and metaanalysis using Cochrane methodology. We searched Cochrane Central Register of Controlled Trials, MEDLINE, and Embase up to 8 September, 2014 for randomized, double-blind, placebo-controlled trials of any opioid for breathlessness, exercise capacity, or HRQL that included at least one participant with COPD. Effects were analyzed as standardized mean differences (SMDs) with 95% confidence intervals (CIs) using random effect models. Measurements and Main Results: A total of 16 studies (15 crossover trials and 1 parallel-group study, 271 participants, 95% with severe COPD) were included. There were no serious adverse effects. Breathlessness was reduced by opioids overall: SMD, 20.35 (95% CI, 20.53 to 20.17; I2, 48.9%), by systemic opioids (eight studies, 118 participants): SMD, 20.34 (95% CI, 20.58 to 20.10; I2, 0%), and less consistently by nebulized opioids (four studies, 82 participants): SMD, 20.39 (95% CI, 20.71 to 20.07; I2, 78.9%). The quality of evidence was moderate for systemic opioids and low for nebulized opioids on breathlessness.Opioids did not affect exercise capacity (13 studies, 149 participants): SMD, 0.06 (95% CI, 20.15 to 0.28; I2, 70.7%). HRQL couldnot be analyzed. Findingswere robust in sensitivity analyses.Risk of study bias was low or unclear. Conclusions: Opioids improved breathlessness but not exercise capacity in severe COPD.

Publication Date


  • 2015

Citation


  • Ekstr��m, M., Nilsson, F., Abernethy, A. A., & Currow, D. C. (2015). Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease a systematic review. Annals of the American Thoracic Society, 12(7), 1079-1092. doi:10.1513/AnnalsATS.201501-034OC

Scopus Eid


  • 2-s2.0-84942246802

Start Page


  • 1079

End Page


  • 1092

Volume


  • 12

Issue


  • 7

Place Of Publication