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Olanzapine Induced Obesity via Multiple-site Activation of H1R-AMPK Signaling

Journal Article


Abstract


  • This project investigated the common pathways of olanzapine induced obesity in multiple brain regions. Western blot analysis was used to investigate the effect of acute and short-term olanzapine treatment on histamine H1 receptor- AMPK activated protein kinase (H1R-AMPK) signaling in the medial base hypothalamus (MBH), paraventricular hypothalamus and brainstem dorsal vagal complex (DVC) in an olanzapine-induced obese rat model. A single injection of olanzapine did not induce hyperphagia but activated the H1R-AMPK signaling in MBH and DVC. 3-day olanzapine injection induce hyperphagia and weight gain, accompanied by activated H1R-AMPK signaling. Phosphor-AMPK was significantly correlated with weight gain. Olanzapine activated H1R-AMPK signaling in multiple-sites and these effects occurred earlier than weight gain onset. Multi-target inhibition of this pathway is of great significance for the treatment of obesity caused by olanzapine.

Publication Date


  • 2020

Citation


  • Zhang, Y., Li, W. T., Huang, X. F., Qian, K., He, M., & Sun, T. L. (2020). Olanzapine Induced Obesity via Multiple-site Activation of H1R-AMPK Signaling. Wuhan Ligong Daxue Xuebao/Journal of Wuhan University of Technology, 42(4). doi:10.3963/j.issn.1671-4431.2020.04.004

Scopus Eid


  • 2-s2.0-85119452874

Web Of Science Accession Number


Volume


  • 42

Issue


  • 4

Abstract


  • This project investigated the common pathways of olanzapine induced obesity in multiple brain regions. Western blot analysis was used to investigate the effect of acute and short-term olanzapine treatment on histamine H1 receptor- AMPK activated protein kinase (H1R-AMPK) signaling in the medial base hypothalamus (MBH), paraventricular hypothalamus and brainstem dorsal vagal complex (DVC) in an olanzapine-induced obese rat model. A single injection of olanzapine did not induce hyperphagia but activated the H1R-AMPK signaling in MBH and DVC. 3-day olanzapine injection induce hyperphagia and weight gain, accompanied by activated H1R-AMPK signaling. Phosphor-AMPK was significantly correlated with weight gain. Olanzapine activated H1R-AMPK signaling in multiple-sites and these effects occurred earlier than weight gain onset. Multi-target inhibition of this pathway is of great significance for the treatment of obesity caused by olanzapine.

Publication Date


  • 2020

Citation


  • Zhang, Y., Li, W. T., Huang, X. F., Qian, K., He, M., & Sun, T. L. (2020). Olanzapine Induced Obesity via Multiple-site Activation of H1R-AMPK Signaling. Wuhan Ligong Daxue Xuebao/Journal of Wuhan University of Technology, 42(4). doi:10.3963/j.issn.1671-4431.2020.04.004

Scopus Eid


  • 2-s2.0-85119452874

Web Of Science Accession Number


Volume


  • 42

Issue


  • 4