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Susceptibility locus for schizophrenia on 10p: Searching for a candidate

Journal Article


Abstract


  • A genome wide survey has been performed in a sample of 71 families using 486 microsatellite markers. Multipoint affected sib pair linkage analysis revealed suggestive evidence for a potential candidate region on chromosome 10p. Further support has been obtained in the family sample but also in an independent sample of 97 simplex families by studying linkage disequilibrium with marker D10S211 using the transmission disequilibrium test (TDT). In order to dissect this region overlapping BAC clones were isolated. A potential candidate gene is in this region, the gene for a phosphatidylinositol phosphate kinase. This enzyme is part of the phosphatidylinositol cycle which is coupled to G proteins and involved in signal transduction for neurotransmitter receptors like the serotonergic receptors 5HT1c, and 5HT2. The exon/intron structure of the gene was determined by BAC-sequencing. Two single nucleotide polymorphisms and one short tandem repeat located in introns close to the boundaries were detected by SSCP analysis and identified by sequencing. All three polymorphisms revealed evidence for association/linkage disequilibrium with schizophrenia in the family sample. Although the gene can be considered as an excellent candidate, the possibility still remains that the novel polymorphisms indicate linkage disequilibrium with another gene in the neighborhood, (supported by Deutsche Forschungsgemeinschaft and a grant from the German-Israeli Foundation).

Publication Date


  • 2000

Citation


  • Schwab, S. G., Eckstein, G. N., Gabel, S., Hallmayer, J., Lerer, B., Albus, M., . . . Wildenauer, D. B. (2000). Susceptibility locus for schizophrenia on 10p: Searching for a candidate. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(4), 461.

Scopus Eid


  • 2-s2.0-0008896937

Web Of Science Accession Number


Start Page


  • 461

Volume


  • 96

Issue


  • 4

Abstract


  • A genome wide survey has been performed in a sample of 71 families using 486 microsatellite markers. Multipoint affected sib pair linkage analysis revealed suggestive evidence for a potential candidate region on chromosome 10p. Further support has been obtained in the family sample but also in an independent sample of 97 simplex families by studying linkage disequilibrium with marker D10S211 using the transmission disequilibrium test (TDT). In order to dissect this region overlapping BAC clones were isolated. A potential candidate gene is in this region, the gene for a phosphatidylinositol phosphate kinase. This enzyme is part of the phosphatidylinositol cycle which is coupled to G proteins and involved in signal transduction for neurotransmitter receptors like the serotonergic receptors 5HT1c, and 5HT2. The exon/intron structure of the gene was determined by BAC-sequencing. Two single nucleotide polymorphisms and one short tandem repeat located in introns close to the boundaries were detected by SSCP analysis and identified by sequencing. All three polymorphisms revealed evidence for association/linkage disequilibrium with schizophrenia in the family sample. Although the gene can be considered as an excellent candidate, the possibility still remains that the novel polymorphisms indicate linkage disequilibrium with another gene in the neighborhood, (supported by Deutsche Forschungsgemeinschaft and a grant from the German-Israeli Foundation).

Publication Date


  • 2000

Citation


  • Schwab, S. G., Eckstein, G. N., Gabel, S., Hallmayer, J., Lerer, B., Albus, M., . . . Wildenauer, D. B. (2000). Susceptibility locus for schizophrenia on 10p: Searching for a candidate. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(4), 461.

Scopus Eid


  • 2-s2.0-0008896937

Web Of Science Accession Number


Start Page


  • 461

Volume


  • 96

Issue


  • 4