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Association studies of HLA genes in families with linkage to chromosome 6p

Journal Article


Abstract


  • Evidence for a potential susceptibility locus for schizophrenia on chromosome 6p has been reported by several groups including our own. In our family sample, the region with possibly linked markers included the microsatellite marker CAR (P = 0.007 for allele sharing in affected sibpairs) which is in linkage disequilibrium with HLA-DQ. There were also reports on a negative association of the DRB1*04 gene locus with schizophrenia [Wright et al., Am J Psych 12:153, 1996]. We analysed the DRB1 locus in a sample of 72 families with linkage to chromosome 6 by affected sib-pair analysis and TDT. Sib-pair analysis revealed Χ2 = 6.43, P = 0.012. No association was detectable for the DRB1*04 allele by TDT (considering both affected siblings: 34 transmitted, 29 nontransmitted). However, a. statistically significant TDT was detected for the DRB1*11 alleles (14 transmitted, 41 nontransmitted, TDT = 13.25; P = 0.00027). In order to test for an association in the presence of linkage, the sample was reduced to only one offspring per family. Despite of the decrease in power, the difference in transmission of DRB1*11 alleles remained statistically significant on a 4% level (not significant upon Bonferroni correction). In conclusion, our data are compatible with the existence of a gene (genes) within or close by to the HLA region on chromosome 6p conferring susceptibility to schizoprenia.

Publication Date


  • 1998

Citation


  • Freymann, J., Schwab, S. G., Knapp, M., Albus, M., Lerer, B., Hallmayer, J., . . . Wildenauer, D. B. (1998). Association studies of HLA genes in families with linkage to chromosome 6p. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 517.

Scopus Eid


  • 2-s2.0-0004558913

Web Of Science Accession Number


Start Page


  • 517

Volume


  • 81

Issue


  • 6

Abstract


  • Evidence for a potential susceptibility locus for schizophrenia on chromosome 6p has been reported by several groups including our own. In our family sample, the region with possibly linked markers included the microsatellite marker CAR (P = 0.007 for allele sharing in affected sibpairs) which is in linkage disequilibrium with HLA-DQ. There were also reports on a negative association of the DRB1*04 gene locus with schizophrenia [Wright et al., Am J Psych 12:153, 1996]. We analysed the DRB1 locus in a sample of 72 families with linkage to chromosome 6 by affected sib-pair analysis and TDT. Sib-pair analysis revealed Χ2 = 6.43, P = 0.012. No association was detectable for the DRB1*04 allele by TDT (considering both affected siblings: 34 transmitted, 29 nontransmitted). However, a. statistically significant TDT was detected for the DRB1*11 alleles (14 transmitted, 41 nontransmitted, TDT = 13.25; P = 0.00027). In order to test for an association in the presence of linkage, the sample was reduced to only one offspring per family. Despite of the decrease in power, the difference in transmission of DRB1*11 alleles remained statistically significant on a 4% level (not significant upon Bonferroni correction). In conclusion, our data are compatible with the existence of a gene (genes) within or close by to the HLA region on chromosome 6p conferring susceptibility to schizoprenia.

Publication Date


  • 1998

Citation


  • Freymann, J., Schwab, S. G., Knapp, M., Albus, M., Lerer, B., Hallmayer, J., . . . Wildenauer, D. B. (1998). Association studies of HLA genes in families with linkage to chromosome 6p. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 517.

Scopus Eid


  • 2-s2.0-0004558913

Web Of Science Accession Number


Start Page


  • 517

Volume


  • 81

Issue


  • 6