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Allelic association between the D10S1423 marker and Alzheimer's disease in a German population

Journal Article


Abstract


  • Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). In this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy subjects and 149 depressed patients. The 234-bp allele of the D10S1423 marker showed a significant association with AD (P = 0.033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10. (C) 2000 Elsevier Science Ireland Ltd.

Publication Date


  • 2000

Citation


  • Majores, M., Bagli, M., Papassotiropoulos, A., Schwab, S. G., Jessen, F., Rao, M. L., . . . Heun, R. (2000). Allelic association between the D10S1423 marker and Alzheimer's disease in a German population. Neuroscience Letters, 289(3), 224-226. doi:10.1016/S0304-3940(00)01283-0

Scopus Eid


  • 2-s2.0-0034637042

Web Of Science Accession Number


Start Page


  • 224

End Page


  • 226

Volume


  • 289

Issue


  • 3

Place Of Publication


Abstract


  • Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). In this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy subjects and 149 depressed patients. The 234-bp allele of the D10S1423 marker showed a significant association with AD (P = 0.033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10. (C) 2000 Elsevier Science Ireland Ltd.

Publication Date


  • 2000

Citation


  • Majores, M., Bagli, M., Papassotiropoulos, A., Schwab, S. G., Jessen, F., Rao, M. L., . . . Heun, R. (2000). Allelic association between the D10S1423 marker and Alzheimer's disease in a German population. Neuroscience Letters, 289(3), 224-226. doi:10.1016/S0304-3940(00)01283-0

Scopus Eid


  • 2-s2.0-0034637042

Web Of Science Accession Number


Start Page


  • 224

End Page


  • 226

Volume


  • 289

Issue


  • 3

Place Of Publication