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Association of SNPs with schizophrenia on chromosome 10p, a region with previously detected linkage

Journal Article


Abstract


  • A genome-wide survey of 71 sib-pair families for linkage with schizophrenia revealed evidence for a susceptibility locus on chromosome 10p supported by other groups. Availability of parents facilitated investigation of association/linkage disequilibrium by the transmission disequilibrium test (TDT). A candidate region of 2-3 Mb has been screened for polymorphisms associated with the trait. Four novel polymorphisms within the genomic sequence of a candidate gene, phosphatidylinositol-4-phosphate-5-kinase (PIP5K2A) have been discovered, four exhibiting P values <.02. One of the SNPs (G/A, P =.0022) was found to be located in exon 7 causing a substitution of asparagine with serine. MALDI TOP mass spectroscopy was used to evaluate additional SNPs available from the SNP Consortium TSC data base. Several SNPs close to the PIP5K2A gene produced nominally significant P values. In addition, two SNPs located appr. 500 kb downstream of the PIPK2A gene yielded P values: of.00056, and P =.017. The positive regions are being further evaluated using all available SNPs and high throughput SNP genotyping using MALDI TOP mass spectroscopy.

Publication Date


  • 2001

Citation


  • Schwab, S. G., Sklar, P., Hallmayer, J., Albus, M., Rietschel, M., Lerer, B., & Wildenauer, D. B. (2001). Association of SNPs with schizophrenia on chromosome 10p, a region with previously detected linkage. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(7), 562.

Scopus Eid


  • 2-s2.0-0142202282

Web Of Science Accession Number


Start Page


  • 562

Volume


  • 105

Issue


  • 7

Abstract


  • A genome-wide survey of 71 sib-pair families for linkage with schizophrenia revealed evidence for a susceptibility locus on chromosome 10p supported by other groups. Availability of parents facilitated investigation of association/linkage disequilibrium by the transmission disequilibrium test (TDT). A candidate region of 2-3 Mb has been screened for polymorphisms associated with the trait. Four novel polymorphisms within the genomic sequence of a candidate gene, phosphatidylinositol-4-phosphate-5-kinase (PIP5K2A) have been discovered, four exhibiting P values <.02. One of the SNPs (G/A, P =.0022) was found to be located in exon 7 causing a substitution of asparagine with serine. MALDI TOP mass spectroscopy was used to evaluate additional SNPs available from the SNP Consortium TSC data base. Several SNPs close to the PIP5K2A gene produced nominally significant P values. In addition, two SNPs located appr. 500 kb downstream of the PIPK2A gene yielded P values: of.00056, and P =.017. The positive regions are being further evaluated using all available SNPs and high throughput SNP genotyping using MALDI TOP mass spectroscopy.

Publication Date


  • 2001

Citation


  • Schwab, S. G., Sklar, P., Hallmayer, J., Albus, M., Rietschel, M., Lerer, B., & Wildenauer, D. B. (2001). Association of SNPs with schizophrenia on chromosome 10p, a region with previously detected linkage. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(7), 562.

Scopus Eid


  • 2-s2.0-0142202282

Web Of Science Accession Number


Start Page


  • 562

Volume


  • 105

Issue


  • 7