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A potential susceptibility locus for schizophrenia on 22q12,13: Re-evaluation in 72 families

Journal Article


Abstract


  • A potential susceptibility locus for schizophrenia on chromosome 22q was first reported by Pulver and colleagues [Am J Med Genet (Neuropsychiatr Genet) 54:36-43, 1994] and later followed up by several groups reporting positive but also negative linkage results for this region. We presented further evidence for a locus by nonparametric analysis in a sample of 54 families with affected sib-pairs (maximum lod score by multipoint analysis 1.9 for marker D22S422) at the last congress. An area of 60 cM was re-evaluated in 74 families (107 all possible sib-pair combinations, 87 independent pairs). A maximum NPL 0.376 was obtained near marker D22S925, a marker that is close to the region of D22S422, where maximum values were obtained in the sample of 54 families. We conclude that a possible locus on chromosome 22 might play a minor role in the development of schizophrenia in our family sample.

Publication Date


  • 1998

Citation


  • Hallmayer, J., Schwab, S. G., Albus, M., Lerer, B., Zill, P., Hanses, C., . . . Wildenauer, D. B. (1998). A potential susceptibility locus for schizophrenia on 22q12,13: Re-evaluation in 72 families. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 529.

Scopus Eid


  • 2-s2.0-0004885812

Web Of Science Accession Number


Start Page


  • 529

Volume


  • 81

Issue


  • 6

Abstract


  • A potential susceptibility locus for schizophrenia on chromosome 22q was first reported by Pulver and colleagues [Am J Med Genet (Neuropsychiatr Genet) 54:36-43, 1994] and later followed up by several groups reporting positive but also negative linkage results for this region. We presented further evidence for a locus by nonparametric analysis in a sample of 54 families with affected sib-pairs (maximum lod score by multipoint analysis 1.9 for marker D22S422) at the last congress. An area of 60 cM was re-evaluated in 74 families (107 all possible sib-pair combinations, 87 independent pairs). A maximum NPL 0.376 was obtained near marker D22S925, a marker that is close to the region of D22S422, where maximum values were obtained in the sample of 54 families. We conclude that a possible locus on chromosome 22 might play a minor role in the development of schizophrenia in our family sample.

Publication Date


  • 1998

Citation


  • Hallmayer, J., Schwab, S. G., Albus, M., Lerer, B., Zill, P., Hanses, C., . . . Wildenauer, D. B. (1998). A potential susceptibility locus for schizophrenia on 22q12,13: Re-evaluation in 72 families. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 529.

Scopus Eid


  • 2-s2.0-0004885812

Web Of Science Accession Number


Start Page


  • 529

Volume


  • 81

Issue


  • 6