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A potential susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia

Journal Article


Abstract


  • Potential linkage to a susceptibility locus for schizophrenia has been recently reported by the NIMH Genetics Initiative Millenium Schizophrenia Consortium [Faraone et al., Am J Med Genet, in press] and by Straub and colleagues from the Medical College of Virginia [Am J Med Genet, in press]. We have scanned initially chromosome 10 with 20 markers in an average distance of 9 cM in 72 families with schizophrenic index patients consisting of at least two affected siblings and their parents. Markers D10S582 (P = 0.0058) and D10S1423 (P = 0.029) revealed highest allele sharing in affected sib-pair analysis. The positive region was further evaluated by typing nine additional markers in an average distance of 2 cM. Multipoint affected sib-pair linkage analysis (ASPEX) revealed a maximum lod score of 2.13 around marker D10S1714. A maximum NPL of 3.2 (P = 0.0007) was obtained for marker D10S1714 using the Genehunter program. Our results support the existence of a gene conferring risk for schizophrenia in 10p.

Publication Date


  • 1998

Citation


  • Schwab, S. G., Hallmayer, J., Albus, M., Lerer, B., Hanses, C., Kanyas, K., . . . Wildenauer, D. B. (1998). A potential susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 528-529.

Scopus Eid


  • 2-s2.0-0000422514

Web Of Science Accession Number


Start Page


  • 528

End Page


  • 529

Volume


  • 81

Issue


  • 6

Abstract


  • Potential linkage to a susceptibility locus for schizophrenia has been recently reported by the NIMH Genetics Initiative Millenium Schizophrenia Consortium [Faraone et al., Am J Med Genet, in press] and by Straub and colleagues from the Medical College of Virginia [Am J Med Genet, in press]. We have scanned initially chromosome 10 with 20 markers in an average distance of 9 cM in 72 families with schizophrenic index patients consisting of at least two affected siblings and their parents. Markers D10S582 (P = 0.0058) and D10S1423 (P = 0.029) revealed highest allele sharing in affected sib-pair analysis. The positive region was further evaluated by typing nine additional markers in an average distance of 2 cM. Multipoint affected sib-pair linkage analysis (ASPEX) revealed a maximum lod score of 2.13 around marker D10S1714. A maximum NPL of 3.2 (P = 0.0007) was obtained for marker D10S1714 using the Genehunter program. Our results support the existence of a gene conferring risk for schizophrenia in 10p.

Publication Date


  • 1998

Citation


  • Schwab, S. G., Hallmayer, J., Albus, M., Lerer, B., Hanses, C., Kanyas, K., . . . Wildenauer, D. B. (1998). A potential susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 528-529.

Scopus Eid


  • 2-s2.0-0000422514

Web Of Science Accession Number


Start Page


  • 528

End Page


  • 529

Volume


  • 81

Issue


  • 6