Abstract
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Potential linkage to a susceptibility locus for schizophrenia has been recently reported by the NIMH Genetics Initiative Millenium Schizophrenia Consortium [Faraone et al., Am J Med Genet, in press] and by Straub and colleagues from the Medical College of Virginia [Am J Med Genet, in press]. We have scanned initially chromosome 10 with 20 markers in an average distance of 9 cM in 72 families with schizophrenic index patients consisting of at least two affected siblings and their parents. Markers D10S582 (P = 0.0058) and D10S1423 (P = 0.029) revealed highest allele sharing in affected sib-pair analysis. The positive region was further evaluated by typing nine additional markers in an average distance of 2 cM. Multipoint affected sib-pair linkage analysis (ASPEX) revealed a maximum lod score of 2.13 around marker D10S1714. A maximum NPL of 3.2 (P = 0.0007) was obtained for marker D10S1714 using the Genehunter program. Our results support the existence of a gene conferring risk for schizophrenia in 10p.