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Investigation of complement C4B deficiency in schizophrenia

Journal Article


Abstract


  • Several lines of evidence suggest that autoimmune mechanisms might contribute to the development of schizophrenia. Important factors involved in immune responses in man include the human leukocyte antigens and components of the complement system. In the present study we attempted to confirm a positive association between a homozygous deficiency in complement factor C4B and schizophrenia as previously reported. We also determined parental genotypes in a subset of our schizophrenic patients to test the hypothesis of a genetic mechanism depending on the mother���s genotype. C4B deficiency was found in similar frequency among patients (n = 176) and controls (n = 145). There was also no increased frequency of C4B deficiency in the mothers of schizophrenic patients. Our study does not support a widespread or consistent association between a deficiency in complement component C4B and schizophrenia. �� 1997 S. Karger AG, Basel.

Publication Date


  • 1997

Citation


  • Schroers, R., N��then, M. M., Rietschel, M., Albus, M., Maier, W., Schwab, S., . . . Dewald, G. (1997). Investigation of complement C4B deficiency in schizophrenia. Human Heredity, 47(5), 279-282. doi:10.1159/000154424

Scopus Eid


  • 2-s2.0-1842332674

Web Of Science Accession Number


Start Page


  • 279

End Page


  • 282

Volume


  • 47

Issue


  • 5

Place Of Publication


Abstract


  • Several lines of evidence suggest that autoimmune mechanisms might contribute to the development of schizophrenia. Important factors involved in immune responses in man include the human leukocyte antigens and components of the complement system. In the present study we attempted to confirm a positive association between a homozygous deficiency in complement factor C4B and schizophrenia as previously reported. We also determined parental genotypes in a subset of our schizophrenic patients to test the hypothesis of a genetic mechanism depending on the mother���s genotype. C4B deficiency was found in similar frequency among patients (n = 176) and controls (n = 145). There was also no increased frequency of C4B deficiency in the mothers of schizophrenic patients. Our study does not support a widespread or consistent association between a deficiency in complement component C4B and schizophrenia. �� 1997 S. Karger AG, Basel.

Publication Date


  • 1997

Citation


  • Schroers, R., N��then, M. M., Rietschel, M., Albus, M., Maier, W., Schwab, S., . . . Dewald, G. (1997). Investigation of complement C4B deficiency in schizophrenia. Human Heredity, 47(5), 279-282. doi:10.1159/000154424

Scopus Eid


  • 2-s2.0-1842332674

Web Of Science Accession Number


Start Page


  • 279

End Page


  • 282

Volume


  • 47

Issue


  • 5

Place Of Publication