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No association or linkage between polymorphisms at the porphobilinogen deaminase gene locus and schizophrenia

Journal Article


Abstract


  • An association between a polymorphic ApaLI site within the porphobilinogen deaminase (PBGD) gene and schizophrenia has been reported recently. In order to replicate this finding we examined the ApaLI RFLP, which is located in intron 1 of the PBGD gene, in 93 unrelated patients who met the DSM-III-R criteria for schizophrenia versus 74 unrelated controls. There were no significant differences between the groups in allele frequencies or genotype counts. Furthermore, a linkage study was performed in 14 families of patients with schizophrenia. No evidence for linkage was obtained for the ApaLI polymorphism. In addition, using multipoint linkage analysis with two flanking CA repeats, we were able to exclude linkage for a region of about 20 cM surrounding the PBGD locus. Our data from both the association and the linkage study do not support a widespread or consistent involvement of the PBGD gene in the etiology of schizophrenia. �� 1993 Rapid Communications of Oxford Ltd.

Publication Date


  • 1993

Citation


  • N��then, M. M., Wildenauer, D., Cichon, S., Schwab, S., Kramer, R., Hallmayer, J., . . . Propping, P. (1993). No association or linkage between polymorphisms at the porphobilinogen deaminase gene locus and schizophrenia. Psychiatric Genetics, 3(2), 101-106. doi:10.1097/00041444-199322000-00006

Scopus Eid


  • 2-s2.0-0027265389

Web Of Science Accession Number


Start Page


  • 101

End Page


  • 106

Volume


  • 3

Issue


  • 2

Place Of Publication


Abstract


  • An association between a polymorphic ApaLI site within the porphobilinogen deaminase (PBGD) gene and schizophrenia has been reported recently. In order to replicate this finding we examined the ApaLI RFLP, which is located in intron 1 of the PBGD gene, in 93 unrelated patients who met the DSM-III-R criteria for schizophrenia versus 74 unrelated controls. There were no significant differences between the groups in allele frequencies or genotype counts. Furthermore, a linkage study was performed in 14 families of patients with schizophrenia. No evidence for linkage was obtained for the ApaLI polymorphism. In addition, using multipoint linkage analysis with two flanking CA repeats, we were able to exclude linkage for a region of about 20 cM surrounding the PBGD locus. Our data from both the association and the linkage study do not support a widespread or consistent involvement of the PBGD gene in the etiology of schizophrenia. �� 1993 Rapid Communications of Oxford Ltd.

Publication Date


  • 1993

Citation


  • N��then, M. M., Wildenauer, D., Cichon, S., Schwab, S., Kramer, R., Hallmayer, J., . . . Propping, P. (1993). No association or linkage between polymorphisms at the porphobilinogen deaminase gene locus and schizophrenia. Psychiatric Genetics, 3(2), 101-106. doi:10.1097/00041444-199322000-00006

Scopus Eid


  • 2-s2.0-0027265389

Web Of Science Accession Number


Start Page


  • 101

End Page


  • 106

Volume


  • 3

Issue


  • 2

Place Of Publication