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Effect of omega-3 supplementation on self-regulation in typically developing preschool-aged children: Results of the omega kid pilot study¿a randomised, double-blind, placebo-controlled trial

Journal Article


Abstract


  • Supplementation of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) may enhance self-regulation (SR) and executive functioning (EF) in children of preschool age. The aim of the Omega Kid Study was to investigate the effect of n-3 LCPUFA supplementation on SR and EF in typically developing preschool-aged children. A double-blind placebo-controlled pilot trial was undertaken, the intervention was 12 weeks and consisted of 1.6 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day compared to placebo. The HS-Omega-3 Index® was assessed by capillary blood samples at baseline and post-intervention. Seventy-eight children were enrolled and randomised to either the n-3 LCPUFA treatment (n = 39) or placebo (n = 39) group. Post intervention, there was a significant three-fold increase in the HS-Omega-3 Index® in the n-3 LCPUFA group (p < 0.001). There were no improvements in SR or EF outcome variables for the n-3 LCPUFA group post intervention compared to the placebo group determined by linear mixed models. At baseline, there were significant modest positive Spearman correlations found between the HS-Omega-3 index® and both behavioural self-regulation and cognitive self-regulation (r = 0.287, p = 0.015 and r = 0.242, p = 0.015 respectively). Although no treatment effects were found in typically developing children, further research is required to target children with sub-optimal self-regulation who may benefit most from n-3 LCPUFA supplementation.

Publication Date


  • 2021

Citation


  • Roach, L. A., Byrne, M. K., Howard, S. J., Johnstone, S. J., Batterham, M., Wright, I. M. R., . . . Meyer, B. J. (2021). Effect of omega-3 supplementation on self-regulation in typically developing preschool-aged children: Results of the omega kid pilot study¿a randomised, double-blind, placebo-controlled trial. Nutrients, 13(10). doi:10.3390/nu13103561

Scopus Eid


  • 2-s2.0-85116724898

Volume


  • 13

Issue


  • 10

Abstract


  • Supplementation of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) may enhance self-regulation (SR) and executive functioning (EF) in children of preschool age. The aim of the Omega Kid Study was to investigate the effect of n-3 LCPUFA supplementation on SR and EF in typically developing preschool-aged children. A double-blind placebo-controlled pilot trial was undertaken, the intervention was 12 weeks and consisted of 1.6 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day compared to placebo. The HS-Omega-3 Index® was assessed by capillary blood samples at baseline and post-intervention. Seventy-eight children were enrolled and randomised to either the n-3 LCPUFA treatment (n = 39) or placebo (n = 39) group. Post intervention, there was a significant three-fold increase in the HS-Omega-3 Index® in the n-3 LCPUFA group (p < 0.001). There were no improvements in SR or EF outcome variables for the n-3 LCPUFA group post intervention compared to the placebo group determined by linear mixed models. At baseline, there were significant modest positive Spearman correlations found between the HS-Omega-3 index® and both behavioural self-regulation and cognitive self-regulation (r = 0.287, p = 0.015 and r = 0.242, p = 0.015 respectively). Although no treatment effects were found in typically developing children, further research is required to target children with sub-optimal self-regulation who may benefit most from n-3 LCPUFA supplementation.

Publication Date


  • 2021

Citation


  • Roach, L. A., Byrne, M. K., Howard, S. J., Johnstone, S. J., Batterham, M., Wright, I. M. R., . . . Meyer, B. J. (2021). Effect of omega-3 supplementation on self-regulation in typically developing preschool-aged children: Results of the omega kid pilot study¿a randomised, double-blind, placebo-controlled trial. Nutrients, 13(10). doi:10.3390/nu13103561

Scopus Eid


  • 2-s2.0-85116724898

Volume


  • 13

Issue


  • 10