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Identification of relaxin immunoreactivity in human follicular fluid

Journal Article


Abstract


  • Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested. © 1986 IRL Press Limited.

Publication Date


  • 1986

Citation


  • Wathes, D. C., Wardle, P. G., Rees, J. M., Mitchell, J. D., Mclaughlin, E. A., Hull, M. G. R., & Porter, D. G. (1986). Identification of relaxin immunoreactivity in human follicular fluid. Human Reproduction, 1(8), 515-517. doi:10.1093/oxfordjournals.humrep.a136465

Scopus Eid


  • 2-s2.0-0022979349

Start Page


  • 515

End Page


  • 517

Volume


  • 1

Issue


  • 8

Abstract


  • Relaxin immunoreactivity has been found in samples of human follicular fluid collected from artificially stimulated pre-ovulatory follicles. The crude extract caused a reduction in the height of the contractions in a rat uterine strip bioassay. The reactive material eluted from Sephadex G50 in two major peaks. The first contained ̃ 60% of the immunoreactivity and had an elution position corresponding to that of porcine relaxin, indicating a mol. wt of ̃ 6000 daltons. The second peak was of a lower mol. wt, but its exact size and significance are unknown. A possible role for relaxin in the process of follicular rupture is suggested. © 1986 IRL Press Limited.

Publication Date


  • 1986

Citation


  • Wathes, D. C., Wardle, P. G., Rees, J. M., Mitchell, J. D., Mclaughlin, E. A., Hull, M. G. R., & Porter, D. G. (1986). Identification of relaxin immunoreactivity in human follicular fluid. Human Reproduction, 1(8), 515-517. doi:10.1093/oxfordjournals.humrep.a136465

Scopus Eid


  • 2-s2.0-0022979349

Start Page


  • 515

End Page


  • 517

Volume


  • 1

Issue


  • 8