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ENDOMETRIOSIS AND OVULATORY DISORDER: REDUCED FERTILISATION IN VITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY

Journal Article


Abstract


  • In-vitro fertilisation (IVF) was carried out once for each of 104 couples who had a single cause of infertility. The group with tubal damage was used as the reference for normal fertilising capacity of both oocytes and sperms: the IVF rates were 68% (71/105) per mature oocyte and 88% (37/42) for couples from whom mature oocytes were recovered. Couples with poor sperm/mucus penetration had reduced IVF rates: 32% (12/38) per oocyte and 60% (9/15) per couple. Sperm function, which was judged normal by means of standard seminal analysis and mucus penetration, was confirmed by normal IVF in unexplained infertility: 63% (37/59) per oocyte and 90% (18/20) per couple. Despite favourable sperm function in their partners, women with endometriosis (without tubal damage) had reduced IVF rates: 33% (19/58) per oocyte and 60% (9/15) per couple. These findings indicate that ovulatory disorder is present in endometriosis and suggest that it causes the associated infertility. �� 1985.

Publication Date


  • 1985

Citation


  • Wardle, P. G., Mclaughlin, E. A., Mcdermott, A., Mitchell, J. D., Ray, B. D., & Hull, M. G. R. (1985). ENDOMETRIOSIS AND OVULATORY DISORDER: REDUCED FERTILISATION IN VITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY. The Lancet, 326(8449), 236-239. doi:10.1016/S0140-6736(85)90289-2

Scopus Eid


  • 2-s2.0-0021872975

Start Page


  • 236

End Page


  • 239

Volume


  • 326

Issue


  • 8449

Place Of Publication


Abstract


  • In-vitro fertilisation (IVF) was carried out once for each of 104 couples who had a single cause of infertility. The group with tubal damage was used as the reference for normal fertilising capacity of both oocytes and sperms: the IVF rates were 68% (71/105) per mature oocyte and 88% (37/42) for couples from whom mature oocytes were recovered. Couples with poor sperm/mucus penetration had reduced IVF rates: 32% (12/38) per oocyte and 60% (9/15) per couple. Sperm function, which was judged normal by means of standard seminal analysis and mucus penetration, was confirmed by normal IVF in unexplained infertility: 63% (37/59) per oocyte and 90% (18/20) per couple. Despite favourable sperm function in their partners, women with endometriosis (without tubal damage) had reduced IVF rates: 33% (19/58) per oocyte and 60% (9/15) per couple. These findings indicate that ovulatory disorder is present in endometriosis and suggest that it causes the associated infertility. �� 1985.

Publication Date


  • 1985

Citation


  • Wardle, P. G., Mclaughlin, E. A., Mcdermott, A., Mitchell, J. D., Ray, B. D., & Hull, M. G. R. (1985). ENDOMETRIOSIS AND OVULATORY DISORDER: REDUCED FERTILISATION IN VITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY. The Lancet, 326(8449), 236-239. doi:10.1016/S0140-6736(85)90289-2

Scopus Eid


  • 2-s2.0-0021872975

Start Page


  • 236

End Page


  • 239

Volume


  • 326

Issue


  • 8449

Place Of Publication