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Sol-gel encapsulation of biomolecules and cells for medicinal applications.

Journal Article


Abstract


  • The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.

Publication Date


  • 2015

Citation


  • Wang, X., Ahmed, N. B., Alvarez, G. S., Tuttolomondo, M. V., Hélary, C., Desimone, M. F., & Coradin, T. (2015). Sol-gel encapsulation of biomolecules and cells for medicinal applications.. Current topics in medicinal chemistry, 15(3), 223-244. doi:10.2174/1568026614666141229112734

Web Of Science Accession Number


Start Page


  • 223

End Page


  • 244

Volume


  • 15

Issue


  • 3

Abstract


  • The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.

Publication Date


  • 2015

Citation


  • Wang, X., Ahmed, N. B., Alvarez, G. S., Tuttolomondo, M. V., Hélary, C., Desimone, M. F., & Coradin, T. (2015). Sol-gel encapsulation of biomolecules and cells for medicinal applications.. Current topics in medicinal chemistry, 15(3), 223-244. doi:10.2174/1568026614666141229112734

Web Of Science Accession Number


Start Page


  • 223

End Page


  • 244

Volume


  • 15

Issue


  • 3