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RNA polymerases from low G+C gram-positive bacteria

Journal Article


Abstract


  • The low G + C Gram-positive bacteria represent some of the most medically and industrially important microorganisms. They are relied on for the production of food and dietary supplements, enzymes and antibiotics, as well as being responsible for the majority of nosocomial infections and serving as a reservoir for antibiotic resistance. Control of gene expression in this group is more highly studied than in any bacteria other than the Gram-negative model  Escherichia coli, yet until recently no structural information on RNA polymerase (RNAP) from this group was available. This review will summarize recent reports on the high-resolution structure of RNAP from the model low G + C representative  Bacillus subtilis, including the role of auxiliary subunits δ and ε, and outline approaches for the development of antimicrobials to target RNAP from this group.

Publication Date


  • 2021

Citation


  • Miller, M., Oakley, A. J., & Lewis, P. J. (2021). RNA polymerases from low G+C gram-positive bacteria. Transcription, 12(4), 92-102. doi:10.1080/21541264.2021.1964328

Scopus Eid


  • 2-s2.0-85112710371

Start Page


  • 92

End Page


  • 102

Volume


  • 12

Issue


  • 4

Abstract


  • The low G + C Gram-positive bacteria represent some of the most medically and industrially important microorganisms. They are relied on for the production of food and dietary supplements, enzymes and antibiotics, as well as being responsible for the majority of nosocomial infections and serving as a reservoir for antibiotic resistance. Control of gene expression in this group is more highly studied than in any bacteria other than the Gram-negative model  Escherichia coli, yet until recently no structural information on RNA polymerase (RNAP) from this group was available. This review will summarize recent reports on the high-resolution structure of RNAP from the model low G + C representative  Bacillus subtilis, including the role of auxiliary subunits δ and ε, and outline approaches for the development of antimicrobials to target RNAP from this group.

Publication Date


  • 2021

Citation


  • Miller, M., Oakley, A. J., & Lewis, P. J. (2021). RNA polymerases from low G+C gram-positive bacteria. Transcription, 12(4), 92-102. doi:10.1080/21541264.2021.1964328

Scopus Eid


  • 2-s2.0-85112710371

Start Page


  • 92

End Page


  • 102

Volume


  • 12

Issue


  • 4