The vibration suppression of the proposed pitch-resistant hydraulically interconnected suspension system for the tri-axle straight truck is investigated, and the vibration isolation performances are parametrically designed to achieve smaller body vibration and tire dynamic load using increased pitch stiffness and optimized pressure loss coefficient. For the hydraulic subsystem, the transfer impedance matrix method is applied to derive the impedance matrix. These hydraulic forces are incorporated into the motion equations of mechanical subsystem as external forces according to relationships between boundary flow and mechanical state vectors. In terms of the additional mode stiffness/damping and suspension performance requirements, the cylinder surface area, accumulator pressure, and damper valve’s pressure loss coefficient are comprehensively tuned with parametric design technique and modal analysis method. It is found the isolation capacity is heavily dependent on installation scheme and fluid physical parameters. Especially, the surface area can be designed for the oppositional installation to separately raise pitch stiffness without increasing bounce stiffness. The pressure loss coefficients are tuned with design of experiment approach and evaluated using all conflict indexes with normalized dimensionless evaluation factors. The obtained numerical results indicate that the proposed pitch-resistant hydraulically interconnected suspension system can significantly inhibit both the body and tire vibrations with decreased suspension deformation, and the tire dynamic load distribution among wheel stations is also improved.