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Theranostic two-dimensional superparamagnetic maghemite quantum structures for ROS-mediated cancer therapy

Journal Article


Abstract


  • In this work, size- and shape-controlled two-dimensional (2D) superparamagnetic maghemite (γ-Fe2O3) quantum flakes (MQFs) with high surface area and mesoporosity were prepared by facile hydrothermal synthesis for biological applications. These quantum flakes exhibited superparamagnetic behaviours over a wide temperature range of 75-950 K with high saturation magnetization ofMs- 23 emu g−1and a lower coercivity ofHc- 6.1 Oe. MQFs also demonstrated a good colloidal stability and a positively charged flake surface. Selective toxicity dependent upon selective ROS scavenging/generation and cellular MQF uptake towards non-malignant human keratinocyte (HaCaT) and malignant melanoma (A357) and human breast cancer (MDA-MB 231) cell lines were witnessed. An increased ROS concentration resulted due to the peroxidase-like activity of MQFs in malignant cells. In contrast, ROS scavenging was observed in non-malignant cells due to dominant catalase-like activity.In vitrofluorescence properties added the diagnostic ability to the ambit of MQFs. Furthermore, the therapeutic efficiency could be significantly enhanced by the hyperthermic (25-47 °C) ability of MQF in cancerous cells. Our findings reveal the novel theranostic MQF structure with immense cancer therapeutic potentialviaaugmentation of ROS generation by hyperthermia in a selective microenvironment.

Publication Date


  • 2021

Citation


  • Rehman, Y., Cheng, Z., Wang, X., Huang, X. F., & Konstantinov, K. (2021). Theranostic two-dimensional superparamagnetic maghemite quantum structures for ROS-mediated cancer therapy. Journal of Materials Chemistry B, 9(29), 5805-5817. doi:10.1039/d1tb01036k

Scopus Eid


  • 2-s2.0-85111430378

Start Page


  • 5805

End Page


  • 5817

Volume


  • 9

Issue


  • 29

Abstract


  • In this work, size- and shape-controlled two-dimensional (2D) superparamagnetic maghemite (γ-Fe2O3) quantum flakes (MQFs) with high surface area and mesoporosity were prepared by facile hydrothermal synthesis for biological applications. These quantum flakes exhibited superparamagnetic behaviours over a wide temperature range of 75-950 K with high saturation magnetization ofMs- 23 emu g−1and a lower coercivity ofHc- 6.1 Oe. MQFs also demonstrated a good colloidal stability and a positively charged flake surface. Selective toxicity dependent upon selective ROS scavenging/generation and cellular MQF uptake towards non-malignant human keratinocyte (HaCaT) and malignant melanoma (A357) and human breast cancer (MDA-MB 231) cell lines were witnessed. An increased ROS concentration resulted due to the peroxidase-like activity of MQFs in malignant cells. In contrast, ROS scavenging was observed in non-malignant cells due to dominant catalase-like activity.In vitrofluorescence properties added the diagnostic ability to the ambit of MQFs. Furthermore, the therapeutic efficiency could be significantly enhanced by the hyperthermic (25-47 °C) ability of MQF in cancerous cells. Our findings reveal the novel theranostic MQF structure with immense cancer therapeutic potentialviaaugmentation of ROS generation by hyperthermia in a selective microenvironment.

Publication Date


  • 2021

Citation


  • Rehman, Y., Cheng, Z., Wang, X., Huang, X. F., & Konstantinov, K. (2021). Theranostic two-dimensional superparamagnetic maghemite quantum structures for ROS-mediated cancer therapy. Journal of Materials Chemistry B, 9(29), 5805-5817. doi:10.1039/d1tb01036k

Scopus Eid


  • 2-s2.0-85111430378

Start Page


  • 5805

End Page


  • 5817

Volume


  • 9

Issue


  • 29