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Cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus curvularia sp

Journal Article


Abstract


  • Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their struc-tures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circu-lar dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activ-ity with IC50 values of 53.7, 32.8, and 12.8 μM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 μM.

Publication Date


  • 2021

Citation


  • Suthiphasilp, V., Raksat, A., Maneerat, T., Hadsadee, S., Jungsuttiwong, S., Pyne, S. G., . . . Laphookhieo, S. (2021). Cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus curvularia sp. Journal of Fungi, 7(6). doi:10.3390/jof7060408

Scopus Eid


  • 2-s2.0-85107111112

Web Of Science Accession Number


Volume


  • 7

Issue


  • 6

Abstract


  • Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their struc-tures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circu-lar dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activ-ity with IC50 values of 53.7, 32.8, and 12.8 μM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 μM.

Publication Date


  • 2021

Citation


  • Suthiphasilp, V., Raksat, A., Maneerat, T., Hadsadee, S., Jungsuttiwong, S., Pyne, S. G., . . . Laphookhieo, S. (2021). Cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus curvularia sp. Journal of Fungi, 7(6). doi:10.3390/jof7060408

Scopus Eid


  • 2-s2.0-85107111112

Web Of Science Accession Number


Volume


  • 7

Issue


  • 6