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EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS

Journal Article


Abstract


  • In 122 diabetic patients there was a significant inverse correlation between plasma-high-density-lipoprotein (H.D.L.)-cholesterol concentrations and glycosylated hæmoglobin concentrations. In an insulin-treated subgroup improvement in diabetic control, confirmed by a decrease in glycosylated hæmoglobin concentrations, was accompanied by a significant rise in plasma-H.D.L.-cholesterol concentration. This result suggests that improved diabetic control may diminish the risk of premature ischæmic heart-disease. When three groups of patients on different treatments were matched for age, sex, weight, and diabetic control, diabetic patients receiving sulphonylureas had significantly lower plasma-H.D.L.-cholesterol concentrations than those receiving insulin or on diet alone, or non-diabetic controls. This association suggests that sulphonylurea administration may constitute a positive risk factor for ischæmic heart-disease in diabetic patients. © 1978.

UOW Authors


  •   Calvert, Dennis D. (external author)

Publication Date


  • 1978

Citation


  • Calvert, G. D., Mannik, T., Graham, J. J., Wise, P. H., & Yeates, R. A. (1978). EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS. The Lancet, 312(8080), 66-68. doi:10.1016/S0140-6736(78)91380-6

Scopus Eid


  • 2-s2.0-0018146744

Web Of Science Accession Number


Start Page


  • 66

End Page


  • 68

Volume


  • 312

Issue


  • 8080

Abstract


  • In 122 diabetic patients there was a significant inverse correlation between plasma-high-density-lipoprotein (H.D.L.)-cholesterol concentrations and glycosylated hæmoglobin concentrations. In an insulin-treated subgroup improvement in diabetic control, confirmed by a decrease in glycosylated hæmoglobin concentrations, was accompanied by a significant rise in plasma-H.D.L.-cholesterol concentration. This result suggests that improved diabetic control may diminish the risk of premature ischæmic heart-disease. When three groups of patients on different treatments were matched for age, sex, weight, and diabetic control, diabetic patients receiving sulphonylureas had significantly lower plasma-H.D.L.-cholesterol concentrations than those receiving insulin or on diet alone, or non-diabetic controls. This association suggests that sulphonylurea administration may constitute a positive risk factor for ischæmic heart-disease in diabetic patients. © 1978.

UOW Authors


  •   Calvert, Dennis D. (external author)

Publication Date


  • 1978

Citation


  • Calvert, G. D., Mannik, T., Graham, J. J., Wise, P. H., & Yeates, R. A. (1978). EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS. The Lancet, 312(8080), 66-68. doi:10.1016/S0140-6736(78)91380-6

Scopus Eid


  • 2-s2.0-0018146744

Web Of Science Accession Number


Start Page


  • 66

End Page


  • 68

Volume


  • 312

Issue


  • 8080