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Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids, and lipoprotein turnover in the pig

Journal Article


Abstract


  • Four young mature male pigs, 110 to 120 kg of body weight, were maintained on a low (0.01%) cholesterol diet. A double changeover design was used so that at any time two pigs received additionally 20 g/day of saponins as a 0.33% solution in drinking water. Saponins raised concentrations of fecal bile acids and neutral sterols and increased the contribution of primary acids to excretion. Neither the concentration of total plasma cholesterol nor low-density and high-density lipoprotein cholesterol were affected by saponins. There was also no change in either absolute or fractional catabolic rate of low-density or high-density lipoprotein apoproteins. The data are discussed in relation to the effects of cholestyramine on plasma cholesterol and bile acid excretion in the pig and to the possible role of saponin-containing foods in the control of plasma cholesterol in man.

UOW Authors


  •   Calvert, Dennis D. (external author)

Publication Date


  • 1980

Citation


  • Topping, D. L., Storer, G. B., Calvert, G. D., Illman, R. J., Oakenfull, D. G., & Weller, R. A. (1980). Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids, and lipoprotein turnover in the pig. American Journal of Clinical Nutrition, 33(4), 783-786. doi:10.1093/ajcn/33.4.783

Scopus Eid


  • 2-s2.0-0019153929

Web Of Science Accession Number


Start Page


  • 783

End Page


  • 786

Volume


  • 33

Issue


  • 4

Abstract


  • Four young mature male pigs, 110 to 120 kg of body weight, were maintained on a low (0.01%) cholesterol diet. A double changeover design was used so that at any time two pigs received additionally 20 g/day of saponins as a 0.33% solution in drinking water. Saponins raised concentrations of fecal bile acids and neutral sterols and increased the contribution of primary acids to excretion. Neither the concentration of total plasma cholesterol nor low-density and high-density lipoprotein cholesterol were affected by saponins. There was also no change in either absolute or fractional catabolic rate of low-density or high-density lipoprotein apoproteins. The data are discussed in relation to the effects of cholestyramine on plasma cholesterol and bile acid excretion in the pig and to the possible role of saponin-containing foods in the control of plasma cholesterol in man.

UOW Authors


  •   Calvert, Dennis D. (external author)

Publication Date


  • 1980

Citation


  • Topping, D. L., Storer, G. B., Calvert, G. D., Illman, R. J., Oakenfull, D. G., & Weller, R. A. (1980). Effects of dietary saponins on fecal bile acids and neutral sterols, plasma lipids, and lipoprotein turnover in the pig. American Journal of Clinical Nutrition, 33(4), 783-786. doi:10.1093/ajcn/33.4.783

Scopus Eid


  • 2-s2.0-0019153929

Web Of Science Accession Number


Start Page


  • 783

End Page


  • 786

Volume


  • 33

Issue


  • 4