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Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population

Journal Article


Abstract


  • The A allele of a common A-T polymorphism in the signal peptide of ��1-antichymotrypsin gene (ACT) has been reported to contribute a two- to threefold increased risk to Alzheimer's disease (AD) patients who carry the apolipoprotein E ��4 (APOE ��4) genotype. Since the ACT expression in AD brains is enhanced in particular in areas that develop amyloid plaques, the ACT polymorphism is considered to be a good candidate gene. We have analyzed this polymorphism in 102 AD patients and 191 matched controls, all originating from Western Germany. No statistically significant differences in allele frequencies and in genotype distribution of ACT could be shown between AD patients and controls. When we analyzed the polymorphism in APOE ��4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers.

Publication Date


  • 1999

Citation


  • Schwab, S. G., Bagli, M., Papassotiropoulos, A., Jessen, F., Maier, W., Rao, M. L., & Heun, R. (1999). Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population. Dementia and Geriatric Cognitive Disorders, 10(6), 469-472. doi:10.1159/000017191

Scopus Eid


  • 2-s2.0-0032711413

Web Of Science Accession Number


Start Page


  • 469

End Page


  • 472

Volume


  • 10

Issue


  • 6

Place Of Publication


Abstract


  • The A allele of a common A-T polymorphism in the signal peptide of ��1-antichymotrypsin gene (ACT) has been reported to contribute a two- to threefold increased risk to Alzheimer's disease (AD) patients who carry the apolipoprotein E ��4 (APOE ��4) genotype. Since the ACT expression in AD brains is enhanced in particular in areas that develop amyloid plaques, the ACT polymorphism is considered to be a good candidate gene. We have analyzed this polymorphism in 102 AD patients and 191 matched controls, all originating from Western Germany. No statistically significant differences in allele frequencies and in genotype distribution of ACT could be shown between AD patients and controls. When we analyzed the polymorphism in APOE ��4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers.

Publication Date


  • 1999

Citation


  • Schwab, S. G., Bagli, M., Papassotiropoulos, A., Jessen, F., Maier, W., Rao, M. L., & Heun, R. (1999). Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population. Dementia and Geriatric Cognitive Disorders, 10(6), 469-472. doi:10.1159/000017191

Scopus Eid


  • 2-s2.0-0032711413

Web Of Science Accession Number


Start Page


  • 469

End Page


  • 472

Volume


  • 10

Issue


  • 6

Place Of Publication