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Daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a ¿-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745

Journal Article


Abstract


  • Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC50 values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC50 = 0.16 mM).

Publication Date


  • 2021

Citation


  • Wutthiwong, N., Suthiphasilp, V., Pintatum, A., Suwannarach, N., Kumla, J., Lumyong, S., . . . Laphookhieo, S. (2021). Daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a ¿-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745. Journal of Fungi, 7(5). doi:10.3390/jof7050358

Scopus Eid


  • 2-s2.0-85106163446

Web Of Science Accession Number


Volume


  • 7

Issue


  • 5

Abstract


  • Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC50 values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC50 = 0.16 mM).

Publication Date


  • 2021

Citation


  • Wutthiwong, N., Suthiphasilp, V., Pintatum, A., Suwannarach, N., Kumla, J., Lumyong, S., . . . Laphookhieo, S. (2021). Daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a ¿-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745. Journal of Fungi, 7(5). doi:10.3390/jof7050358

Scopus Eid


  • 2-s2.0-85106163446

Web Of Science Accession Number


Volume


  • 7

Issue


  • 5