Abstract
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Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a ��-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3���5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed ��-glucosidase inhibitory activity with IC50 values ranging from 0.16���0.85 mM and compound 1 was the best ��-glucosidase inhibitory activity (IC50 = 0.16 mM).