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Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism

Journal Article


Abstract


  • Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.

Publication Date


  • 2015

Citation


  • Zanotti, I., Dall'Asta, M., Mena, P., Mele, L., Bruni, R., Ray, S., & Del Rio, D. (2015). Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism. Food and Function, 6(1), 13-31. doi:10.1039/c4fo00670d

Scopus Eid


  • 2-s2.0-84922976178

Web Of Science Accession Number


Start Page


  • 13

End Page


  • 31

Volume


  • 6

Issue


  • 1

Abstract


  • Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.

Publication Date


  • 2015

Citation


  • Zanotti, I., Dall'Asta, M., Mena, P., Mele, L., Bruni, R., Ray, S., & Del Rio, D. (2015). Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism. Food and Function, 6(1), 13-31. doi:10.1039/c4fo00670d

Scopus Eid


  • 2-s2.0-84922976178

Web Of Science Accession Number


Start Page


  • 13

End Page


  • 31

Volume


  • 6

Issue


  • 1