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Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis (Lour.) Corner

Journal Article


Abstract


  • The phytochemical investigation of the fruit and leaf extracts of Maclura cochinchinensis (Lour.) Corner (Moraceae) resulted in the isolation and identification of four undescribed isoflavones (macluracochinones A-D) and one undescribed flavone (macluracochinone E), together with 24 known compounds. The structures of the undescribed compounds were elucidated using nuclear magnetic resonance (NMR) and high-resolution electrospray ionization time-of-flight mass spectrometry (HRESITOFMS) experiments. Gancaonin M, lupiwighteone, lupalbigenin, warangalone, auriculatin, and millexatin F displayed good antibacterial activities against Gram-positive bacteria with MIC values in the range of 1–8 μg/mL. Lupalbigenin showed strong activities against methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus with the same MIC value of 1 μg/mL.

Publication Date


  • 2021

Citation


  • Polbuppha, I., Suthiphasilp, V., Maneerat, T., Charoensup, R., Limtharakul, T., Cheenpracha, S., . . . Laphookhieo, S. (2021). Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis (Lour.) Corner. Phytochemistry, 187. doi:10.1016/j.phytochem.2021.112773

Scopus Eid


  • 2-s2.0-85104070643

Web Of Science Accession Number


Volume


  • 187

Abstract


  • The phytochemical investigation of the fruit and leaf extracts of Maclura cochinchinensis (Lour.) Corner (Moraceae) resulted in the isolation and identification of four undescribed isoflavones (macluracochinones A-D) and one undescribed flavone (macluracochinone E), together with 24 known compounds. The structures of the undescribed compounds were elucidated using nuclear magnetic resonance (NMR) and high-resolution electrospray ionization time-of-flight mass spectrometry (HRESITOFMS) experiments. Gancaonin M, lupiwighteone, lupalbigenin, warangalone, auriculatin, and millexatin F displayed good antibacterial activities against Gram-positive bacteria with MIC values in the range of 1–8 μg/mL. Lupalbigenin showed strong activities against methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus with the same MIC value of 1 μg/mL.

Publication Date


  • 2021

Citation


  • Polbuppha, I., Suthiphasilp, V., Maneerat, T., Charoensup, R., Limtharakul, T., Cheenpracha, S., . . . Laphookhieo, S. (2021). Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis (Lour.) Corner. Phytochemistry, 187. doi:10.1016/j.phytochem.2021.112773

Scopus Eid


  • 2-s2.0-85104070643

Web Of Science Accession Number


Volume


  • 187