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Neocortical neurogenesis in humans is restricted to development

Journal Article


Abstract


  • Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of 14C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally. © 2006 by The National Academy of Sciences of the USA.

UOW Authors


  •   Fink, David (external author)

Publication Date


  • 2006

Citation


  • Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., . . . Frisén, J. (2006). Neocortical neurogenesis in humans is restricted to development. Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12564-12568. doi:10.1073/pnas.0605177103

Scopus Eid


  • 2-s2.0-33747605325

Start Page


  • 12564

End Page


  • 12568

Volume


  • 103

Issue


  • 33

Abstract


  • Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of 14C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally. © 2006 by The National Academy of Sciences of the USA.

UOW Authors


  •   Fink, David (external author)

Publication Date


  • 2006

Citation


  • Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., . . . Frisén, J. (2006). Neocortical neurogenesis in humans is restricted to development. Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12564-12568. doi:10.1073/pnas.0605177103

Scopus Eid


  • 2-s2.0-33747605325

Start Page


  • 12564

End Page


  • 12568

Volume


  • 103

Issue


  • 33