Skip to main content
placeholder image

The effect of perioperative vitamin c on postoperative analgesic consumption: A meta-analysis of randomized controlled trials

Journal Article


Abstract


  • Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = −0.68, 95% CI: −1.01 to −0.36, p < 0.0001; I2 = 57%) and a lower morphine consumption (weighted mean difference (WMD) = −2.44 mg, 95% CI: −4.03 to −0.86, p = 0.003; I2 = 52%) in the vitamin group than that in the placebo group within postoperative 1–2 h. At postoperative 24 h, a lower pain score (SMD = −0.65, 95% CI: −1.11 to −0.19, p = 0.005; I2 = 81%) and lower morphine consumption (WMD = −6.74 mg, 95% CI: −9.63 to −3.84, p < 0.00001; I2 = 85%) were also noted in the vitamin group. Subgroup analyses demonstrated significant reductions in pain severity and morphine requirement immediately (1–2 h) and 24 h after surgery for patients receiving intravenous vitamin C but not in the oral subgroup. These findings showed significant reductions in pain score and opioid requirement up to postoperative 24 h, respectively, suggesting the effectiveness of perioperative vitamin C use. Further large-scale trials are warranted to elucidate its optimal intravenous dosage and effectiveness against chronic pain in the postoperative pain control setting.

UOW Authors


  •   Chen, Kee-Hsin (external author)

Publication Date


  • 2020

Citation


  • Hung, K. C., Lin, Y. T., Chen, K. H., Wang, L. K., Chen, J. Y., Chang, Y. J., . . . Sun, C. K. (2020). The effect of perioperative vitamin c on postoperative analgesic consumption: A meta-analysis of randomized controlled trials. Nutrients, 12(10), 1-17. doi:10.3390/nu12103109

Scopus Eid


  • 2-s2.0-85092459375

Start Page


  • 1

End Page


  • 17

Volume


  • 12

Issue


  • 10

Abstract


  • Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = −0.68, 95% CI: −1.01 to −0.36, p < 0.0001; I2 = 57%) and a lower morphine consumption (weighted mean difference (WMD) = −2.44 mg, 95% CI: −4.03 to −0.86, p = 0.003; I2 = 52%) in the vitamin group than that in the placebo group within postoperative 1–2 h. At postoperative 24 h, a lower pain score (SMD = −0.65, 95% CI: −1.11 to −0.19, p = 0.005; I2 = 81%) and lower morphine consumption (WMD = −6.74 mg, 95% CI: −9.63 to −3.84, p < 0.00001; I2 = 85%) were also noted in the vitamin group. Subgroup analyses demonstrated significant reductions in pain severity and morphine requirement immediately (1–2 h) and 24 h after surgery for patients receiving intravenous vitamin C but not in the oral subgroup. These findings showed significant reductions in pain score and opioid requirement up to postoperative 24 h, respectively, suggesting the effectiveness of perioperative vitamin C use. Further large-scale trials are warranted to elucidate its optimal intravenous dosage and effectiveness against chronic pain in the postoperative pain control setting.

UOW Authors


  •   Chen, Kee-Hsin (external author)

Publication Date


  • 2020

Citation


  • Hung, K. C., Lin, Y. T., Chen, K. H., Wang, L. K., Chen, J. Y., Chang, Y. J., . . . Sun, C. K. (2020). The effect of perioperative vitamin c on postoperative analgesic consumption: A meta-analysis of randomized controlled trials. Nutrients, 12(10), 1-17. doi:10.3390/nu12103109

Scopus Eid


  • 2-s2.0-85092459375

Start Page


  • 1

End Page


  • 17

Volume


  • 12

Issue


  • 10