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Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Journal Article


Abstract


  • An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © 2011 Royal Society of Chemistry.

Publication Date


  • 2011

Citation


  • Zhang, Y., Wee Kee, C., Lee, R., Fu, X., Ying-Teck Soh, J., Foong Loh, E. M., . . . Tan, C. H. (2011). Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines. Chemical Communications, 47(13), 3897-3899. doi:10.1039/c0cc05840h

Scopus Eid


  • 2-s2.0-79952640759

Start Page


  • 3897

End Page


  • 3899

Volume


  • 47

Issue


  • 13

Abstract


  • An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © 2011 Royal Society of Chemistry.

Publication Date


  • 2011

Citation


  • Zhang, Y., Wee Kee, C., Lee, R., Fu, X., Ying-Teck Soh, J., Foong Loh, E. M., . . . Tan, C. H. (2011). Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines. Chemical Communications, 47(13), 3897-3899. doi:10.1039/c0cc05840h

Scopus Eid


  • 2-s2.0-79952640759

Start Page


  • 3897

End Page


  • 3899

Volume


  • 47

Issue


  • 13