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Interferon response to dipyridamole in lupus erythematosus patients.

Journal Article


Abstract


  • Studies in patients with autoimmune disorders strongly support a role for interferon (IFN) in the disease process. In the present study we investigated the in vivo production of alpha-IFN in lupus erythematosus patients after stimulation with dipyridamole, recently characterized as an alpha-IFN inducer in mice and humans. Levels of IFN were measured in serum samples from 22 patients with systemic lupus erythematosus (SLE) and 12 patients with discoid lupus erythematosus (DLE) before and 24 h after dipyridamole administration. IFN activity was assayed on human and bovine cells in parallel. Initial serum concentrations of alpha-IFN in SLE patients were markedly elevated. The percentage of DLE positive responders to dipyridamole induction was about twice as high as that found for SLE. Studies of factors responsible for IFN production in lupus erythematosus might result in better understanding of the relationship between DLE and SLE.

Publication Date


  • 1989

Citation


  • Konstantinov, K., Galabov, A., & Mastikova, M. (1989). Interferon response to dipyridamole in lupus erythematosus patients.. The British journal of dermatology, 121(1), 59-63. doi:10.1111/j.1365-2133.1989.tb01400.x

Web Of Science Accession Number


Start Page


  • 59

End Page


  • 63

Volume


  • 121

Issue


  • 1

Abstract


  • Studies in patients with autoimmune disorders strongly support a role for interferon (IFN) in the disease process. In the present study we investigated the in vivo production of alpha-IFN in lupus erythematosus patients after stimulation with dipyridamole, recently characterized as an alpha-IFN inducer in mice and humans. Levels of IFN were measured in serum samples from 22 patients with systemic lupus erythematosus (SLE) and 12 patients with discoid lupus erythematosus (DLE) before and 24 h after dipyridamole administration. IFN activity was assayed on human and bovine cells in parallel. Initial serum concentrations of alpha-IFN in SLE patients were markedly elevated. The percentage of DLE positive responders to dipyridamole induction was about twice as high as that found for SLE. Studies of factors responsible for IFN production in lupus erythematosus might result in better understanding of the relationship between DLE and SLE.

Publication Date


  • 1989

Citation


  • Konstantinov, K., Galabov, A., & Mastikova, M. (1989). Interferon response to dipyridamole in lupus erythematosus patients.. The British journal of dermatology, 121(1), 59-63. doi:10.1111/j.1365-2133.1989.tb01400.x

Web Of Science Accession Number


Start Page


  • 59

End Page


  • 63

Volume


  • 121

Issue


  • 1