Skip to main content
placeholder image

Clinical manifestations in patients with autoantibodies specific for nuclear lamin proteins.

Journal Article


Abstract


  • IgG antibodies to nuclear lamin proteins have been found in serum samples from 31 patients using immunofluorescence on HEp-2 cells, Western blotting, and enzyme-linked immunosorbent assay, performed against a nuclear lamina preparation from Ehrlich ascites tumor cells. Antilamin antibodies were most prevalent among patients with nonerosive, seronegative polyarthritis, or patients showing serum antiphospholipid reactivity as well. It is possible that anti-lamin antibodies may thus be a marker for a subgroup of polyarthritis patients who have a different prognosis from that of those with seropositive rheumatoid arthritis. The mechanism for the combined occurrence of anti-lamin and antiphospholipid autoantibodies is obscure. Future studies will answer whether these two antibodies represent a distinct antibody profile in patients with antiphospholipid antibody syndrome.

Publication Date


  • 1992

Citation


  • Konstantinov, K., Halberg, P., Wiik, A., Høier-Madsen, M., Wantzin, P., Ullman, S., & Galcheva-Gargova, Z. (1992). Clinical manifestations in patients with autoantibodies specific for nuclear lamin proteins.. Clinical immunology and immunopathology, 62(1 Pt 1), 112-118. doi:10.1016/0090-1229(92)90030-r

Web Of Science Accession Number


Start Page


  • 112

End Page


  • 118

Volume


  • 62

Issue


  • 1 Pt 1

Abstract


  • IgG antibodies to nuclear lamin proteins have been found in serum samples from 31 patients using immunofluorescence on HEp-2 cells, Western blotting, and enzyme-linked immunosorbent assay, performed against a nuclear lamina preparation from Ehrlich ascites tumor cells. Antilamin antibodies were most prevalent among patients with nonerosive, seronegative polyarthritis, or patients showing serum antiphospholipid reactivity as well. It is possible that anti-lamin antibodies may thus be a marker for a subgroup of polyarthritis patients who have a different prognosis from that of those with seropositive rheumatoid arthritis. The mechanism for the combined occurrence of anti-lamin and antiphospholipid autoantibodies is obscure. Future studies will answer whether these two antibodies represent a distinct antibody profile in patients with antiphospholipid antibody syndrome.

Publication Date


  • 1992

Citation


  • Konstantinov, K., Halberg, P., Wiik, A., Høier-Madsen, M., Wantzin, P., Ullman, S., & Galcheva-Gargova, Z. (1992). Clinical manifestations in patients with autoantibodies specific for nuclear lamin proteins.. Clinical immunology and immunopathology, 62(1 Pt 1), 112-118. doi:10.1016/0090-1229(92)90030-r

Web Of Science Accession Number


Start Page


  • 112

End Page


  • 118

Volume


  • 62

Issue


  • 1 Pt 1