Due to global warming and shortage of fossil fuels, the grid-connected solar photovoltaic (PV) system has gained significant popularity all over the world. The modular multilevel cascaded (MMC) inverter is the natural choice for step-up transformer and line filter less direct medium voltage grid integration of solar PV systems. However, power quality and loss are the important issues while connecting the PV system to the medium voltage grid through MMC inverter. Modulation technique is the key to maintain output power quality, e.g., total harmonic distortion (THD) and to ensure low switching and conduction losses. In this paper, an advanced modulation technique named “triangle saturated common mode pulse width modulation (TSCMPWM)” control is proposed for a 3-phase 5-level MMC inverter-based grid-tied PV system. Compared to traditional modulation techniques, the proposed TSCMPWM control offers the lowest voltage THD as well as lower inverter power losses. Performance of the proposed modulation technique is evaluated in MATLAB/Simulink environment and tested with a reduced scale prototype test platform. Both simulation and experimental results show the effectiveness of the proposed modulation technique.