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Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats

Journal Article


Abstract


  • High intake of simple sugars is generally seen as a detrimental factor in the etiology of both obesity and insulin resistance. To examine possible deleterious effects of sucrose, independent of changes in energy intake, rats were fed equal amounts of high-sucrose or high-starch diets over 4 wk. Energy expenditure was assessed by open-circuit respirometry and carcass analysis. In vivo insulin action in individual tissues was assessed with the hyperinsulinemic (1 nmol/L), euglycemic clamp combined with tracer glucose and 2-deoxyglucose administration. Whole-body glucose disposal was impaired by sucrose feeding (clamp glucose infusion rate of 77 ± 4 vs 124 ± 6 μmol/[kg·min], p < 0.001, for sucrose and starch, respectively) because of a major impairment of insulin action at the liver with a smaller contribution from peripheral tissues. Sucrose feeding affected neither basal or stimulated energy expenditure nor accumulation of body fat. In conclusion, sucrose feeding produces a major impairment of insulin action, predominantly because of an effect at the liver.

UOW Authors


  •   Jenkins, Arthur (external author)

Publication Date


  • 1988

Citation


  • Storlien, L. H., Kraegen, E. W., Jenkins, A. B., & Chisholm, D. J. (1988). Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats. American Journal of Clinical Nutrition, 47(3), 420-427. doi:10.1093/ajcn/47.3.420

Scopus Eid


  • 2-s2.0-0023900954

Start Page


  • 420

End Page


  • 427

Volume


  • 47

Issue


  • 3

Abstract


  • High intake of simple sugars is generally seen as a detrimental factor in the etiology of both obesity and insulin resistance. To examine possible deleterious effects of sucrose, independent of changes in energy intake, rats were fed equal amounts of high-sucrose or high-starch diets over 4 wk. Energy expenditure was assessed by open-circuit respirometry and carcass analysis. In vivo insulin action in individual tissues was assessed with the hyperinsulinemic (1 nmol/L), euglycemic clamp combined with tracer glucose and 2-deoxyglucose administration. Whole-body glucose disposal was impaired by sucrose feeding (clamp glucose infusion rate of 77 ± 4 vs 124 ± 6 μmol/[kg·min], p < 0.001, for sucrose and starch, respectively) because of a major impairment of insulin action at the liver with a smaller contribution from peripheral tissues. Sucrose feeding affected neither basal or stimulated energy expenditure nor accumulation of body fat. In conclusion, sucrose feeding produces a major impairment of insulin action, predominantly because of an effect at the liver.

UOW Authors


  •   Jenkins, Arthur (external author)

Publication Date


  • 1988

Citation


  • Storlien, L. H., Kraegen, E. W., Jenkins, A. B., & Chisholm, D. J. (1988). Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats. American Journal of Clinical Nutrition, 47(3), 420-427. doi:10.1093/ajcn/47.3.420

Scopus Eid


  • 2-s2.0-0023900954

Start Page


  • 420

End Page


  • 427

Volume


  • 47

Issue


  • 3