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Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and c-reactive protein in adolescents¿a multi-cohort study

Journal Article


Abstract


  • Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age-and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy nonoverweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.

UOW Authors


  •   Roberto Dos Santos, Rute (external author)

Publication Date


  • 2020

Citation


  • Agostinis-Sobrinho, C., Rosário, R., Santos, R., Norkiene, S., Mota, J., Rauckien¿-Michaelsson, A., . . . Ramírez-Vélez, R. (2020). Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and c-reactive protein in adolescents¿a multi-cohort study. Nutrients, 12(5). doi:10.3390/nu12051461

Scopus Eid


  • 2-s2.0-85085089843

Web Of Science Accession Number


Volume


  • 12

Issue


  • 5

Abstract


  • Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12–18 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age-and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy nonoverweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.

UOW Authors


  •   Roberto Dos Santos, Rute (external author)

Publication Date


  • 2020

Citation


  • Agostinis-Sobrinho, C., Rosário, R., Santos, R., Norkiene, S., Mota, J., Rauckien¿-Michaelsson, A., . . . Ramírez-Vélez, R. (2020). Higher cardiorespiratory fitness levels may attenuate the detrimental association between weight status, metabolic phenotype and c-reactive protein in adolescents¿a multi-cohort study. Nutrients, 12(5). doi:10.3390/nu12051461

Scopus Eid


  • 2-s2.0-85085089843

Web Of Science Accession Number


Volume


  • 12

Issue


  • 5