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Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.

Journal Article


Abstract


  • Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's syndrome (trisomy 21). Here we generate transgenic mice to investigate the consequences of overexpression of Ets2. We find that mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities. These abnormalities have similarities with the skeletal anomalies found in trisomy-16 mice and humans with Down's syndrome, in which the gene dosage of Ets2 is increased. Our results indicate that Ets2 has a role in skeletal development and implicate the overexpression of Ets2 in the genesis of some skeletal abnormalities that occur in Down's syndrome.

UOW Authors


  •   Venter, Deon (external author)

Publication Date


  • 1996

Published In


Citation


  • Sumarsono, S. H., Wilson, T. J., Tymms, M. J., Venter, D. J., Corrick, C. M., Kola, R., . . . Kola, I. (1996). Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.. Nature, 379(6565), 534-537. doi:10.1038/379534a0

Web Of Science Accession Number


Start Page


  • 534

End Page


  • 537

Volume


  • 379

Issue


  • 6565

Abstract


  • Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's syndrome (trisomy 21). Here we generate transgenic mice to investigate the consequences of overexpression of Ets2. We find that mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities. These abnormalities have similarities with the skeletal anomalies found in trisomy-16 mice and humans with Down's syndrome, in which the gene dosage of Ets2 is increased. Our results indicate that Ets2 has a role in skeletal development and implicate the overexpression of Ets2 in the genesis of some skeletal abnormalities that occur in Down's syndrome.

UOW Authors


  •   Venter, Deon (external author)

Publication Date


  • 1996

Published In


Citation


  • Sumarsono, S. H., Wilson, T. J., Tymms, M. J., Venter, D. J., Corrick, C. M., Kola, R., . . . Kola, I. (1996). Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.. Nature, 379(6565), 534-537. doi:10.1038/379534a0

Web Of Science Accession Number


Start Page


  • 534

End Page


  • 537

Volume


  • 379

Issue


  • 6565