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Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

Journal Article


Abstract


  • Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

Publication Date


  • 2017

Citation


  • Ellis, S. R., Soltwisch, J., Paine, M. R. L., Dreisewerd, K., & Heeren, R. M. A. (2017). Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids. Chemical Communications, 53(53), 7246-7249. doi:10.1039/c7cc02325a

Scopus Eid


  • 2-s2.0-85021626950

Start Page


  • 7246

End Page


  • 7249

Volume


  • 53

Issue


  • 53

Abstract


  • Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

Publication Date


  • 2017

Citation


  • Ellis, S. R., Soltwisch, J., Paine, M. R. L., Dreisewerd, K., & Heeren, R. M. A. (2017). Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids. Chemical Communications, 53(53), 7246-7249. doi:10.1039/c7cc02325a

Scopus Eid


  • 2-s2.0-85021626950

Start Page


  • 7246

End Page


  • 7249

Volume


  • 53

Issue


  • 53