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Characterization of spin adducts obtained with hydrophobic nitrone spin traps

Journal Article


Abstract


  • Several 5-alkyl-3,3,5-trimethylpyrroline 1 -oxides have been prepared and their ability to trap a number of radicals has been investigated. In each case the addition to the nitrone is stereospecific and affords only one of the two possible geometric isomers of the resulting nitroxyl radical. The addition of a hydrogen atom gives nitroxyls containing two non-equivalent α-protons, the spectra of which are very similar to that observed during the red blood cell haemolysis induced by phenylhydrazine in the presence of a similar spin trap. A re-interpretation of the results obtained in the biological system appears to be warranted. © 1985, Royal Society of Chemistry. All rights reserved.

Publication Date


  • 1985

Citation


  • Barker, P., Beckwith, A. L. J., Cherry, W. R., & Huie, R. (1985). Characterization of spin adducts obtained with hydrophobic nitrone spin traps. Journal of the Chemical Society, Perkin Transactions 2, (2), 1147-1150. doi:10.1039/p29850001147

Scopus Eid


  • 2-s2.0-37049108737

Start Page


  • 1147

End Page


  • 1150

Issue


  • 2

Abstract


  • Several 5-alkyl-3,3,5-trimethylpyrroline 1 -oxides have been prepared and their ability to trap a number of radicals has been investigated. In each case the addition to the nitrone is stereospecific and affords only one of the two possible geometric isomers of the resulting nitroxyl radical. The addition of a hydrogen atom gives nitroxyls containing two non-equivalent α-protons, the spectra of which are very similar to that observed during the red blood cell haemolysis induced by phenylhydrazine in the presence of a similar spin trap. A re-interpretation of the results obtained in the biological system appears to be warranted. © 1985, Royal Society of Chemistry. All rights reserved.

Publication Date


  • 1985

Citation


  • Barker, P., Beckwith, A. L. J., Cherry, W. R., & Huie, R. (1985). Characterization of spin adducts obtained with hydrophobic nitrone spin traps. Journal of the Chemical Society, Perkin Transactions 2, (2), 1147-1150. doi:10.1039/p29850001147

Scopus Eid


  • 2-s2.0-37049108737

Start Page


  • 1147

End Page


  • 1150

Issue


  • 2