La(NO3)3 and La2O3 doped titanium-zirconium-molybdenum (TZM) alloys were fabricated by using powder metallurgy method, and their room and high temperature mechanical properties were studied in this paper. Results show that the mechanical properties of La(NO3)3-TZM alloy sheet is better than that of La2O3-TZM alloy sheet in room temperature and the high temperature mechanical properties of both alloys have similar change trend but different sensitivity of temperature. The tiny grains in La(NO3)3-TZM alloy sheet is more sensitive to temperature and the lanthanum doping significantly influences the temperature sensitivity of the alloy. When the temperature is lower than 1400����C, both TZM alloy sheets present a transgranular fracture mode. It is ductile intergranular fracture mode when the temperature is higher than 1400����C, and the temperature of fracture mode transition is 1400����C.