Skip to main content
placeholder image

Biology at the nanoscale, one molecule at a time

Conference Paper


Abstract


  • Advances in optical imaging and molecular manipulation techniques have made it possible to observe individual proteins and record molecular movies that provide new insight into their dynamics and reaction mechanisms. In a biological context, most of these proteins function in concert with other proteins in large complexes, so an important direction is the utilization of single-molecule techniques to unravel the orchestration of large macromolecular assemblies. I will discuss the development of such tools to study DNA replication. In particular, I will focus on the role of micromanipulation techniques, microfluidic approaches, and imaging methods in such single-molecule studies. Copyright © (2013) by the Chemical and Biological Microsystems Society All rights reserved.

Publication Date


  • 2013

Citation


  • Van Oijen, A. M. (2013). Biology at the nanoscale, one molecule at a time. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 Vol. 1 (pp. 1).

Scopus Eid


  • 2-s2.0-84907362273

Web Of Science Accession Number


Start Page


  • 1

Volume


  • 1

Abstract


  • Advances in optical imaging and molecular manipulation techniques have made it possible to observe individual proteins and record molecular movies that provide new insight into their dynamics and reaction mechanisms. In a biological context, most of these proteins function in concert with other proteins in large complexes, so an important direction is the utilization of single-molecule techniques to unravel the orchestration of large macromolecular assemblies. I will discuss the development of such tools to study DNA replication. In particular, I will focus on the role of micromanipulation techniques, microfluidic approaches, and imaging methods in such single-molecule studies. Copyright © (2013) by the Chemical and Biological Microsystems Society All rights reserved.

Publication Date


  • 2013

Citation


  • Van Oijen, A. M. (2013). Biology at the nanoscale, one molecule at a time. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 Vol. 1 (pp. 1).

Scopus Eid


  • 2-s2.0-84907362273

Web Of Science Accession Number


Start Page


  • 1

Volume


  • 1